http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
B형 간염바이러스 감염에서 불투명 유리상 간세포(Groundglass hepatocyte)의 원인으로서 pre-S1 변이종의 의의
조용균 ( Yong Kyun Cho ),김병익 ( Byung Ik Kim ),배지철 ( Ji Cheul Pae ),박승하 ( Seung Ha Park ),김상훈 ( Sang Hoon Kim ),박정호 ( Jung Ho Park ),김홍주 ( Hong Joo Kim ),박동일 ( Dong Il Park ),김향 ( Hyang Kim ),성인경 ( In Kyu 대한내과학회 2005 대한내과학회지 Vol.69 No.4
Background : Ground glass hepatocytes are unique histological feature of chronic hepatitis B viral infection. The pre-S1 region of large surface protein has been shown to regulate assembly, processing, and secretion of HBsAg. The purpose of this study was to elucidate that a mutant form of pre-S1 affects this normal secretory pathway and is responsible for ground glass hepatocyte. Methods : We examined HBV sequences spanning the pre-S region from a patients with HBeAg positive chronic HBV infection. HBV DNA was extracted from serum, cloned, and sequenced and determined the intrahepatic viral composition by extracting HBV DNA from paraffin embedded liver tissue. To analyze the viral population of single groundglass hepatocytes, we used the technique of laser capture microdissection to isolate individual hepatocytes from biopsy specimen. Groundglass hepatocytes that stained positively with anti-HBs and normal hepatocytes were harvested individually and their subjected HBV DNA sequences were analyzed. To define the responsible mutations for the HBsAg secretion, we introduced the mutant gene into molecular clone of wildtype (adwR9) and assayed their HBsAg amounts in the transfected cell supernatants by ELISA. Results : Of 12 clones in serum analyzed, 9 clones had identical wild type sequences in the N-terminal region of the pre-S1 protein which plays an important role in the secretion and retention of HBV envelope proteins. One of the wild type clones has deletion within pre-S2 region. 3 identical mutant clones were isolated. Mutant type clones were predominant groundglass hepatocytes. Conclusions : We speculate that a mutant form of the HBV pre-S1 protein may result in the formation of ground-glass hepatocytes. Expression of abnormal pre-S1 may lead to its retention and accumulation within hepatocytes.(Korean J Med 69:357-363, 2005)
조용균 ( Y. K. Cho ),김창섭 ( C. S. Kim ),김시영 ( S. Y. Kim ),박창영 ( C. Y. Park ),손정일 ( C. I. Sohn ),전우규 ( W. K. Jeon ),김병익 ( B. I. Kim ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 배변조영술은 항문직장의 해부학적 정보를 제공해줄뿐아니라 배변시 역동적인 변화 및 골반저의 운동상태를 파악할 수 잇다. 최근 골반저의 위치와 근육 운동성 이상이 기능성 배변장애의 중요한 요인으로 생각되어지고 있다. 이러한 이상은 배변 자세에 따라 다양하게 변할 수 있고 만성 특발성 변비 주에서도 특히 골반폐쇄성 변비환자에서 영향을 미칠 수 있다고 한다. 또한 재래식 변기 사용시의 자세가 배변에 더 용이할 수 있다는 경험적 증거를 토대로 골반폐쇄성
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; Lamivudine 치료 후 만성 B형 간염환자의 혈청내 Nitric Oxide(NO) 대사체 농도의 감소
조용균 ( Jo Yong Gyun ),김병익 ( Kim Byeong Ig ),황상태 ( Hwang Sang Tae ),김정욱 ( Kim Jeong Ug ),이준행 ( Lee Jun Haeng ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),전우규 ( Jeon U Gyu ),모지원 ( Mo Ji Won ),박창신 ( Pa 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
배변 자세에 따른 배변조영술에서의 항문직장각 및 회음하수의 변화
조용균 ( Yong Kyun Cho ),김창섭 ( Chang Seop Kim ),구은실 ( Eun Sil Koo ),윤중원 ( Jung Won Yun ),김정욱 ( Jeong Wook Kim ),이준행 ( Jun Haeng Lee ),박창영 ( Chang Young Park ),손정일 ( Chong Il Sohn ),전우규 ( Woo Kyu Jeon ),김 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
Background/Aims: Pelvic floor location and mobility vary according to the defecation posture. Authors investigated possible effects of the change of defecation posture on the patients with pelvic outlet obstructive constipation among patients with chronic idiopathic constipation. Methods: Subjects included in the study were 32 patients with pelvic outlet obstructive constipation (24 spastic pelvic floor syndrome, 8 perineal descent syndrome). From all the subjects, defecographies of both resting and straining phases were obtained for three different postures (sitting, leg elevating and squatting). Results: In the patients with spastic pelvic floor syndrome, the anorectal angles of straining phase in squatting position were 117.93±3.58캻nd 118.2±4.94?respectively. These values were significantly greater than those measured in sitting position (resting 93.75±6.74?straining 95.17±7.77?and leg elevating position (resting 99.42±4.79?straining 98.67±5.76?(p<0.01, p<0.01, respectively). In addition, in the patients with perineal descent syndrome, perineal descent in squatting position revealed no significant differences compared with sitting and leg elevating positions. Conclusions: In patients with spastic pelvic floor syndrome, squatting position increases the anorectal angle. Although further studies are needed to support our ideas, this study demonstrates that patients with spastic pelvic floor syndrome can have benefit from the Korean traditional defecation posture by increasing the anorectal angle. (Korean J Gastroenterol 2003;41:190-195)
만성 간질환 환자에서 혈소판감소증과 혈청 Thrombopoietin 의 관계
조용균(Yong Kyun Cho),김병익(Byung Ik Kim),구은실(Eun Sil Koo),김시영(Si Young Kim),김창섭(Chang Seop Kim),박창영(Chang Young Park),손정일(Chong Il Sohn),전우규(Woo Kyu Jeon),정을순(Eul Soon Jung),이숭환(Soong Hwan Lee),이동후(Dong H 대한소화기학회 2002 대한소화기학회지 Vol.39 No.2
Background/Aims: The major origin of thrombocytopenia in liver cirrhosis is attributed to enlarged spleen. In order to determine the influence of thromboprotein (TPO) on the origin of thrombocytopenia in liver disease, we measured serum TPO levels in patients with chronic liver diseases. Methods: The study included 18 controls, 26 patients with chronic viral hepatitis, 35 patients with viral liver cirrhosis, and 28 patients with alcoholic liver cirrhosis. We determined their serum thrombopoietin levels by ELISA. Results: The TPO levels of patients with chronic viral hepatitis (147.9 ± 40.9 pg/mL) was significantly higher than those in patients with viral cirrhosis (95.9 ± 50.0 pg/mL), alcoholic cirrhosis (100.8 ± 43.5 pg/mL) or controls (108.1 ± 41.7 pg/mL). In the patients with viral and alcoholic liver cirrhosis, TPO showed a significant positive relationship with prothrombin time (ρ=0.4315, p=0.011 vs ρ=0.4171, p=0.030) and albumin (ρ=0.4939, p=0.003 vs ρ=0.4852, p=0.010). However, TPO levels had a significant inverse relationship with Child-Pugh score (ρ=-0.6151, p=0.000 vs ρ=-0.4658, p=0.014). Conclusion: Serum TPO levels were elevated in patients with chronic viral hepatitis by compensatory mechanism. Along with hypersplenism, low TPO production may play a role in the development of thrombocytopenia in patients with liver cirrhosis, but further studies are needed. (Korean J Gastroenterol 2002;39:108-113)
임신성 고혈압과 정상 산모 태아에서의 제대혈 leptin 측정에 대한 연구
김명환 ( Kim Myeong Hwan ),조용균 ( Jo Yong Gyun ),고지경 ( Go Ji Gyeong ),강웅선 ( Kang Ung Seon ),박기현 ( Park Gi Hyeon ),이철민 ( Lee Cheol Min ),최훈 ( Choe Hun ),김복린 ( Kim Bog Lin ),이홍균 ( Lee Hong Gyun ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.12
Objective : Leptin, the protein encoded by the Ob gene in the adipose cell, is produced by the placenta during pregnancy and materanal serum leptin is increased in preeclampsia. The objective of this study was to compare umbilical cord plasma leptin level
김정욱 ( Kim Jeong Ug ),전우규 ( Jeon U Gyu ),윤중원 ( Yun Jung Won ),박동일 ( Park Dong Il ),조용균 ( Jo Yong Gyun ),성인경 ( Seong In Gyeong ),박창영 ( Park Chang Yeong ),손정일 ( Son Jeong Il ),김병익 ( Kim Byeong Ig ),김은정 ( 대한소화기학회 2004 대한소화기학회지 Vol.43 No.2
Background/Aims: Increased intestinal permeability has been possible contributing factors to the pathogenesis of alcoholic liver disease. Moreover, it can contribute to the development of bacterial infection and intestinal endotoxemia in patients with liver cirrhosis. This study aimed to examine the difference of intestinal barrier dysfunction between alcoholic and viral liver disease patients through the comparison of the intestinal permeabilities of patients with clinical characteristics. Methods: Intestinal permeabilities were measured in 18 healthy controls, 41 patients with alcoholic liver disease (17 cases of alcoholic liver disease without cirrhosis and 24 cases of alcoholic liver cirrhosis) and 46 patients with viral liver disease (14 cases of chronic viral hepatitis and 32 cases of viral liver cirrhosis) by measuring 24 hour urine excretion of 51Cr-EDTA. Results: The intestinal permeability was significantly increased in the patients with alcoholic liver disease without cirrhosis (5.62±80%), alcoholic liver cirrhosis (5.29±48%) and viral liver cirrhosis (3.15±39%) compared with that in control subjects (1.99±53%). On the contrary, it was not increased in the patients with chronic viral hepatitis (2.05±57%) versus controls. The significant correlation was not found between intestinal permeability and clinical and laboratory findings. Conclusions: The intestinal permeability was elevated in patients with alcoholic liver disease compared to those with viral liver cirrhosis. The pathophysiology of liver injury secondary to intestinal epithelial damage may be different between alcoholic and viral liver diseases. (Korean J Gastroenterol 2004; 43:104-111)