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조신제,문형우,배웅진,박용현,하유신,홍성후,김세웅,이지열 대한비뇨기종양학회 2019 대한비뇨기종양학회지 Vol.17 No.3
Purpose: In this study, we attempted to characterize capsaicin’s effects with regard to the apoptosis of murine bladder cancer cells (MBT-2) as well as the pharmacodynamics of nano-encapsulated capsaicin formulation for intravesical instillation. Materials and Methods: We assessed the viability of the MBT-2 cells via MTT staining, agarose gel electrophoresis, and flow cytometric apoptosis analysis. Intravesical reagents were instilled into 3 groups of male white New Zealand rabbits. Instillation agents were nano-encapsulated capsaicin dissolved in saline, capsaicin dissolved in saline, and capsaicin dissolved in dimethyl sulfoxide (DMSO). We also determined the pharmacokinetics of urine, plasma, and bladder tissue after intravesical capsaicin instillation. Results: Capsaicin treatment was determined to reduce cell viability in a time- and dose-dependent manner. The capsaicin concentrations in the urine of the rabbits decreased in each of the treatment groups, but we noted a more profound reduction of capsaicin concentration in the nano-encapsulated capsaicin group. Plasma concentrations were definitely lower as compared with the levels measured in the bladder tissue and urine. We noted distinctive differences in patterns of concentration change between the capsaicin with normal saline solution (NSS) or DMSO and the nano-encapsulated capsaicin groups. The concentration of nano-encapsulated capsaicin in the tissue appeared to increase directly with tissue depth. Conclusions: Our results show that capsaicin can induce apoptosis in MBT-2 cells, as well as the excellent permeation properties of nano-encapsulated capsaicin. Treatment with intravesical capsaicin may be a promising alternative therapeutic modality for the treatment of bladder cancer.
적응 미지입력 관측기를 이용한 무인항공기의 조종면 구동기 고장진단
조신제,최승기,문정호,노은정 제어로봇시스템학회 2008 제어로봇시스템학회 국내학술대회 논문집 Vol.2008 No.10
In this paper, a parallel bank of multiple adaptive unknown input observers approach suggested in [1] is applied to detect a single fault of control surface actuator and to estimate the actuator position of lock-in-place fault using a small fixed-wing UAV model with eight control surfaces. This paper shows that not only the fault diagnosis algorithm detects and estimates each faults of lock-in-place in 1 second by simulation but also it may be unavailable to isolate among two rudders.
적응 미지입력 관측기를 이용한 무인항공기의 조종면 구동기 고장진단
조신제(Shinje Cho),신성식(Sungsik Shin),최승기(Seungkie Choi),문정호(Jungho Moon),노은정(Eunjung Roh) 한국항공우주학회 2010 韓國航空宇宙學會誌 Vol.38 No.12
본 논문은 항공기의 신뢰도를 높이기 위한 목적으로, 항공기 조종면에 장착된 구동기에 고장이 발생하여 특정위치에 고정되어 움직이지 않을 때, 다중 미지입력 관측기(UIO, Unknown Input Observer)와 적응기법을 이용하여 고장이 발생한 구동기를 구분하고 해당 조종면의 고정된 위치를 추정하여, 조종력 할당 알고리듬 등의 조종면 고장에 대한 재형상 제어를 위한 입력을 제공하는 방법을 다룬다. 구동기의 개수와 동일한 관측기를 구성하되, 각 구동기의 고장이 반영된 선형모델을 사용함으로써 정상인 경우의 관측기에서 출력된 잔차와 고장이 발생한 경우의 관측기에서 출력된 잔차를 비교하여 고장을 분리하고, 적응기법을 이용하여 1초 내에 고장의 정도를 추정한다. 그러나 2개의 통일 형상의 러더가 존재할 경우, 고장분리가 불가함을 밝힌다. In this paper, a parallel bank of multiple adaptive unknown input observers approach suggested by D.Wang is applied to detect a single fault of control surface actuator and to estimate the actuator position of lock-in-place fault using a small fixed-wing UAV model with eight control surfaces. This paper shows that not only the fault diagnosis algorithm detects and estimates each faults of lock-in-place in 1 second by simulation but also it may be unavailable to isolate among two same-shaped rudders.
조신제(Shin-Je Cho),장대수(Dae-Su Jang),탁민제(Min-Jae Tahk),구훤준(Hueon-Joon Koo),김종성(Jong-Soeng Kim) 한국항공우주학회 2006 韓國航空宇宙學會誌 Vol.34 No.4
본 논문에서는 항공기충돌방지장치인 TCAS-Ⅱ를 응용한 무인항공기의 충돌회피를 다룬다. TCAS-Ⅱ의 최소운용성능표준 문서에 기초한 시뮬레이션 프로그램을 구현하고, TCAS-Ⅱ가 제공하는 다양한 수직회피 명령을 자동조종장치의 입력으로 변환하여 최대고도변화율이 상이한 두 가지 무인항공기의 충돌회피 성능을 비교분석한다. 낮은 최대고도 변화율을 가진 무인항공기에 TCAS-Ⅱ를 적용할 때 발생 가능한 Near Mid-Air Collision을 방지할 수 있는 방안으로서, 최대고도변화율과 고도를 고려한 개선된 알고리듬을 제안하였다. 이 알고리듬은 ADS-B 개념에 의한 보다 넓은 감시범위가 제공된다는 전제하에 사용될 수 있다. In this paper, the collision avoidance of Unmanned Aerial Vehicles(UAVs) by applying the Traffic alert and Collision Avoidance System Ⅱ(TCAS-Ⅱ) is introduced. The performances of two UAVs whose maximum vertical rates are different each other are compared and analysed by not only converting many TCAS-Ⅱ commands into an autopilot input but also implementing a computer program based on the Minimum Operational Performance Standards for TCAS-Ⅱ. As the alternative to a possible Near Mid-Air Collision for UAVs whose maximum vertical rates are low, we have proposed a modified algorithm considering the maximum vertical rate and altitude. The modified algorithm is available on the assumption that a wider surveillance range is provided by a ADS-B system.
Shin Jay Cho(조신제),Hyong Woo Moon(문형우),Woong Jin Bae(배웅진),Yong-Hyun Park(박용현),U-Syn Ha(하유신),Sung-Hoo Hong(홍성후),Sae Woong Kim(김세웅),Ji Youl Lee(이지열) 대한비뇨기종양학회 2019 대한비뇨기종양학회지 Vol.17 No.3
Purpose: In this study, we attempted to characterize capsaicin’s effects with regard to the apoptosis of murine bladder cancer cells (MBT-2) as well as the pharmacodynamics of nano-encapsulated capsaicin formulation for intravesical instillation. Materials and Methods: We assessed the viability of the MBT-2 cells via MTT staining, agarose gel electrophoresis, and flow cytometric apoptosis analysis. Intravesical reagents were instilled into 3 groups of male white New Zealand rabbits. Instillation agents were nano-encapsulated capsaicin dissolved in saline, capsaicin dissolved in saline, and capsaicin dissolved in dimethyl sulfoxide (DMSO). We also determined the pharmacokinetics of urine, plasma, and bladder tissue after intravesical capsaicin instillation. Results: Capsaicin treatment was determined to reduce cell viability in a time- and dose-dependent manner. The capsaicin concentrations in the urine of the rabbits decreased in each of the treatment groups, but we noted a more profound reduction of capsaicin concentration in the nano-encapsulated capsaicin group. Plasma concentrations were definitely lower as compared with the levels measured in the bladder tissue and urine. We noted distinctive differences in patterns of concentration change between the capsaicin with normal saline solution (NSS) or DMSO and the nano-encapsulated capsaicin groups. The concentration of nano-encapsulated capsaicin in the tissue appeared to increase directly with tissue depth. Conclusions: Our results show that capsaicin can induce apoptosis in MBT-2 cells, as well as the excellent permeation properties of nano-encapsulated capsaicin. Treatment with intravesical capsaicin may be a promising alternative therapeutic modality for the treatment of bladder cancer.
문정호,조신제,최승기 한국항공우주학회 2012 한국항공우주학회 학술발표회 논문집 Vol.2012 No.11
최근의 비행제어소프트웨어 개발 방법은 모델기반개발(MBD) 또는 컴포넌트 기반 개발(CBD)로 발전하고 있다. 특히 비행제어법칙 분야는 OFP 및 하드웨어 분야보다 상대적으로 많은 무기체계에 MBD 기술이 적용되고 있으며 본 연구에서는 다양한 고정익 무인항공기에 탑재되는 비행제어법칙의 구조를 파악하고 MBD 개발방법의 중요기술인 자동코드생성을 고려하여 고정익 정찰용 무인항공기에 적용 가능한 오픈아키텍쳐 형태의 제어법칙 모델을 설계하였다. The process of the development of the flight control software is progressing to the Model-Based-Development (MBD) and Component-Based-Development (CBD). Especially MBD technology is applied to the control law of many weapon system compared to Operational Flight Program (OFP) and hardware. In this research, after analysis of control law model architectures of various UAV, open-architecture control law model is designed for a fixed-wing reconnaissance UAV considering auto-code generation that is important in MBD technology.
문정호,조신제,최윤한,김홍대 한국항공우주학회 2014 한국항공우주학회 학술발표회 논문집 Vol.2014 No.11
지상 정밀위치추적장비를 기반으로 한 고정익 무인항공기의 자동착륙 비행시험 결과를 분석하였다. 본 논문에서는 자동착륙에 필요한 플랩특성시험, 자동착륙 제어기 성능을 검증하기 위한 오프셋 통과 시험, 지상 정밀위치추적장비 정확도 검증 시험, 자동착륙 수동회항시험, 자동착륙시험 데이터 분석 결과 등을 다룬다. 계절별 수 차례의 비행시험을 통해 설계된 자동착륙 운용로직 및 제어기의 성능을 확인하고 자동착륙 시스템의 신뢰성을 검증하였다. Flight test results of a fixed-wing UAV based on a ground precise location tracking system. In this paper, flight test for flap performance verification, validation of the ground precise location tracking system, off-set bypass flight test for pre-validation of the automatic landing control performance, results of automatic landing flight test data analysis were described. Finally performance and system reliability of the designed automatic landing operational logics and controller were verified through variety of flight tests seasonally.