Anti-oxidative Effects of RADIX REHMANNIAE PREPARATA on Toxic Agent Induced Kidney Cell Injury

조수인 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4

전체과제제시와 부분과제연습이 학습자의 사전인지기능에 따라 문제해결과 인지부하에 미치는 영향

조수연(趙修年),정선영(鄭善永) 서울대학교 교육연구소 2011 아시아교육연구 Vol.12 No.2

본 연구는 교육현장에서 복합적 인지기술의 습득을 위한 교수설계모형으로 알려진 4C/ID모형의 네 가지 요 소 중 전체과제제시와 부분과제연습이 학습자의 사전인지기능에 따라 문제해결과 인지부하에 미치는 영향을 검증하였다. 본 연구를 위해 I시 소재 중학교 108명의 학생이 실험에 참여하였다. 본 연구는 ‘엑셀 학습 프로그램’을 총 7주에 걸쳐 실시하였다. 연구 결과, 복합적 인지기술을 필요로 하는 학습과제의 경우 전체과제제시를 제공하였을 때 문제해결을 쉽게 할 수 있었으며, 문제해결에 대하여 학습전략과 사전인지기능 간에 상호작용효과가 있었다. 즉, 전체과제제시는 사전인지기능이 높은 상위집단이 사전인지기능이 낮은 집단보다 상대적으로 효과적이었다. 또한, 전체과제제시는 본유적 인지부하를 높여주었다. 그러나 인지부하에 대하여 학습전략과 사전인지기능 간에는 상호작용효과가 없었다. 본 연구결과 복합적 문제해결을 위해서는 전체과제제시를 사용하는 것이 효과적이라는 것을 시사해 준다. 따라서, 전체과제제시는 문제해결 시 본유적 인지부하를 높여 주는 역할을 하기 때문에, 본 연구는 실제 교실환경에서 복합적 문제해결 시 전체과제제시전략의 사용을 제안한다. The current study is to investigate the effects of whole task practice and part task practice among four components of 4CID model, which is instructional design model for complex cognitive skill acquisition. 108 subjects from middle school located in I city participated. For the purpose, an instructional program for excel was conducted for seven weeks. After completing the program, post-test for problem solving and cognitive load test was administered. As the research results, subjects were able to solve problems better when whole task practice was provided. There was an interaction effects between learning strategies and previous cognitive skills. That is to say, while whole task practice was effective for the subjects with higher previous cognitive skills, part task practice was effective for the subjects with lower previous cognitive skills. Also, whole task practice raised germane cognitive load. Previous cognitive load skills had significant interaction effects for all types of cognitive load. However, there was no interaction effects between learning strategies and previous cognitive skills. The current research results reports that whole task practice is more effective for students with high cognitive skills whereas part task practice is more effective for students with low cognitive skills. Since the whole task practice took a role of raising the germane cognitive load while students solve a problem, we suggest whole task practice strategies for complex cognitive problem solving in the practical classroom learning environment.

당선소감_조수일

조수일 고요아침 2017 열린시학 Vol.22 No.2

치매 치료를 위한 한약 자원 탐색에서 네트워크 약리학 분석법의 유용성

조수인,Suin Cho 턱관절균형의학회 2022 턱관절균형의학회지 Vol.12 No.1

Objectives: Dementia is a disease in which a person maintains a normal intellectual level during the growth period, but has acquired cognitive impairment and personality change. In this study, we tried to check whether the network pharmacology analysis method is useful in the search for herbal medicine resources for the treatment of dementia. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database is a database frequently used in Chinese medicine research. We used the TCMSP to identify herbal medicines and their molecular targets that can be used for dementia by using network pharmacology research methods. Results: It was possible to select 28 types of components that are expected to be active by applying them to the living body, and 75 types of targets that these components act on were secured. In addition, 16 kinds of drugs were identified by checking the drugs containing 28 kinds of ingredients, and it was found that Radix Salviae contained 2 kinds of the selected 28 kinds of ingredients. Conclusions: Through this study, we were able to identify ingredients, drugs, and targets that can be used for basic and clinical research on dementia.

목화 부위별 추출물의 암 세포주 증식 억제 효과

조수인,문경일,김형우,정현우 대한본초학회 2006 大韓本草學會誌 Vol.21 No.1

石菖蒲 추출물이 생쥐의 사회ㆍ심리적 스트레스에 미치는 영향

조수인,김형우,졍용식 대한본초학회 2004 大韓本草學會誌 Vol.19 No.4

Objectives : Stress is one of the deleterious factors for health, and many diseases are likely to be related to stress. The effects of Acorus Graminei Rhizoma extract were tested for the anti-sociopsychological stress action. Methods : 250g of dried Acorus Graminei Rhizoma was extracted(AGE) with pure water and the total extractive was evaporated under reduced pressure to give 39.7g. ICR male mice(20±2g) were fed orally with the dose of 100㎎/㎏/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : AGE administered group showed a significant decrease of serum corticosterone secretion compared with control group. Noradrenaline secretions in the dorsal cortex of brain showed no change. Lipid peroxidation of the liver and serum of mice were tested by measuring malondialdehyde, but AGE admistration showed no change. Conclusion : Above results suggest that AGE can rid the sociopsychological stress by decreasing serum corticosterone secretion.

Genome Wide Expression Analysis of the Effect of Woowhangchongshim-won on Rat Brain Injury

조수인,Kim, Bu-Yeo,Lim, Se-Hyun,Kim, Hyun-Young,Kim, Young-Kyun,Lim, Chi-Yeon,Cho, Su-In 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

Objectives : ICH breaks down blood vessels within the brain parenchyma, which finally leads to neuronal loss, drugs to treat ICH have not yet been established. In this experiment, we measured the effect of Woowhangchongshim-won (WWCSW) on intracerebral hemorrhage (ICH) in rat using microarray technology. Methods : We measured the effect of WWCSW on ICH in rat using microarray technology. ICH was induced by injection of collagenase type IV, and total RNA was isolated. Image files of microarray were measured using a ScanArray scanner, and the criteria of the threshold for up- and down-regulation was 2 fold. Hierarchical clustering was implemented using CLUSTER and TREEVIEW program, and for Ontology analysis. GOSTAT program was applied in which p-value was calculated by Chi square or Fisher's exact test based on the total array element. Results : WWCSW-treatment restored the gene expression altered by ICH-induction in brain to the levels of 76.0% and 70.1% for up- and down-regulated genes, respectively. Conclusion : Co-regulated genes by ICH model of rat could be used as molecular targets for therapeutic effects of drug including WWCSW. That is, the presence of co-regulated genes may represent the importance of these genes in ICH in the brain and the change of expression level of these co-regulated genes would also indicate the functional change of brain tissue.

재일조선인의 주체적 이동과 ‘8·15’의 자기서사 : 김석범의 『1945년 여름』을 중심으로

조수일(CHO, Su-Il)(趙秀一) 한일민족문제학회 2020 한일민족문제연구 Vol.38 No.-

This paper focused on the autonomous movement and floating self of Kim, Tae-Jo, the protagonist of a serial novel titled “Summer in 1945,” written by a Zainichi(在日) Korean author named Kim, Seok-Beom. The aim was to capture the question thrown out to readers through this representation and self-narrative. First, the ‘mother country’ to Kim, Tae-Jo would have been the Japanese Empire in Boots. However, the author derived a thinking process for the quaternity of mother country, Korea, Korean language, and Korean people through the experience of meeting the ‘nature of hometown’ called ‘Korean language.’ In Hometown, Kim, Tae-Jo showed a defense mechanism of using the Japanese language and describing himself as a Japanese person, which formed a crack in the quaternity concept. Also, the protagonist was pointed out as a figure who regards the embodiment of the quaternity to be the most important proposition while objectifying his floating self and repeating self-questioning.Next, Wandering was analyzed by focusing on questions generated repeatedly when the protagonist conflicts with a different language called the ‘native Korean language’ in the unfamiliar world of Gangwon-do where ‘the land breathings like the heat spouted by grass.’ Such questions are fundamental questions asking whether the Korean language is a single language and what the Korean language is. This paper pointed out the narrative that describes the reasoning of the protagonist, which cannot take place within the time frame of the novel. This narrative was found to be a sign that foretells Part 4 Departure. This paper contemplated on the fact that Summer in 1945 is a story that reorients the floating self while reminding the time described outside the world of the novel. Lastly, this paper paid attention to the reason of the protagonist who self-questions ceaselessly about the confrontation of the Korean language and the Japanese language and Korean people and Japanese people in Departure. Since the liberation occurred when the protagonist was in Japan, he was unable to find the significance of the ‘August 15 Liberation.’ For this reason, he had to continue asking for the meaning of the ‘August 15 Liberation.’ The embodiment of Kim, Tae-Jo, who moved autonomously from Japan back to the liberated homeland, was an intent to reexamine ‘August 15’ by placing his living body in the unfamiliar world of liberated Joseon. He wanted to face his limits constantly by pushing his floating self into reality. 本稿は、在日朝鮮人作家·金石範の連作小説『1945年夏』を、主人公· 金泰造の主体的移動と流動する自己に焦点を当て、その形象化に企図された 読者への問いを捉えようとしたものである。 まず、｢長靴 ちょうか｣では、金泰造にとっての｢祖国｣は皇祖の国としての大日本帝 国であったが、｢朝鮮語｣という｢故郷の自然｣に出会う移動の経験を通じて祖国 =朝鮮=朝鮮語=朝鮮人という四位一体の観念が生成する思考のプロセスを 明らかにした。 次に、｢故郷｣では、生成された四位一体の観念的な認識に齟齬をきたす日 本語と日本人としての自己という金泰造の防衛機制を導き出した。また、主人 公はその流動し続ける自己を対象化して｢自問｣を繰り返しつつ、四位一体の体 現を至上命題とする人物であることを読み解いた。 続いて、｢彷徨｣においては、主人公が江原道の｢草いきれのような土地の息 吹きのする｣異界で｢土着の朝鮮語｣という異言語に出会うことによって反復的に 生成される問いに焦点を当て物語を分析した。それは、朝鮮語は単一ではない のではないか、はたして朝鮮語とは何かという根本的な問いである。さらに、物語現在では考えられないことを考える主人公の内面を描写する語りをとりあげ、そ れは第四部｢出発｣を予告する前兆であることや、『1945年夏』は物語世界外か ら物語られる時間を想起し、流動し続ける自己を定位し直す構造からなる物語 であることを示した。 最後に、｢出発｣を中心に、自己における朝鮮語と日本語、朝鮮人と日本 人とのせめぎ合いに対し、｢自問｣し続ける主人公の内的思考に注目し、日本 で<8·15>を迎えた金泰造にとって、｢8·15解放｣は依然としてその意味を定位 することができない出来事であり、それ故に彼は｢8·15解放｣の内実を事後的に 問い続けているということを捉えた。また、再び日本から解放された祖国へと主 体的に移動することを描いたのは、解放された朝鮮という異界に生身の体を置い て<8·15>を捉え直すためであり、その現実に流動し続ける自己を追いやること で、現在の自己の限界に絶えず向き合うためであることを示した。

[당선작_조수일] 앵글로피쉬의 변명 외 3편

조수일 고요아침 2017 열린시학 Vol.22 No.2

『四君子湯』이 수은에 의한 생쥐의 신장 조직 손상에 미치는 영향

조수인 한국한의학연구원 2001 한국한의학연구원논문집 Vol.7 No.1

Objectives : This study was carried out to research the protective effects of Sasang-Tang (SA) through in vivio experiments, and tried to investigate the relation between oxidation of renal tissues and deficiency of Qi. Mehods : Acute renal injury which initiated from free radical induced by HgCl₂, were applied to mice and metabolic data were obtained. In order to measure the degree of renal injury, serum level of creatinine, blood urea nitrogen(BUN), total protein(TP) and glucose were measured. Besides, serum level of alanine aminotransferase(AST), aspartate aminotransferase(ALT) were measure too. Lipid peroxidation of renal cortex was examined by measuring malondialdehyde(MDA), a product of lopid peroxidation. Results : SA had productive effects on acute renal injury caused by decrease of glomerular filtration which was initiated by subcutaneous injection of HgCl. SA protected acute liver injury too. Conclusions : Through this study, we found that SA have healing effects on renal injury of HgCl₂induced oxidative stress that is similar to deficiency of Qi. And further studies have to followed to certify the mechanisms.