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위 선암종에서의 E-cadherin, $\beta$-catenin 및 c-Met 단백 발현에 대한 연구
조성진,김민경,신봉경,민연기,조민영,서성옥,원남희,채양석,Cho Seong Jin,Kim Min Kyung,Shin Bong Kyung,Min Youn Ki,Cho Min Young,Suh Sung Ock,Won Nam Hee,Chae Yang Seok 대한위암학회 2001 대한위암학회지 Vol.1 No.2
Purpose: E-cadherin is an adhesion molecule essential for tight connection between cells, forming the cadherin/catenin complex. Truncated $\beta$-catenin disrupts the interaction between E-cadherin and $\alpha$-catenin, leading to the loss of intercellular adhesion. Met protein, the hepatocyte growth factor receptor, plays important roles in signal transduction. We investigated the relationships between the expressions of E-cadherin, $\beta$-catenin, and c-met protein and the clinicopathological and prognostic parameters in gastric adenocarcinomas. Materials and Methods: The patterns of E-cadherin, $\beta$-catenin, and c-met protein expression were studied using immunohistochemistry in formalin-fixed, paraffin-embedded archival tissues from 76 surgically resected gastric adenocarcinomas. Results: Increased expressions of E-cadherin, $\beta$-catenin, and c-met were more significantly correlated in early gastric cancers (EGC) than in advanced gastric cancers (AGC) (P=0.002, P=0.003 and P=0.026). The positive immunoreactivities of all three markers were markedly lower in signet ring-cell type and poorly differentiated type lesions than in intestinal-type lesions. Decreased expression of the $\beta$-catenin protein correlated well with increased tumor invasion depth (P=0.039), and increased lymph node metastasis correlated well with reduced expression of c-met (P=0.046). Conclusion: In gastric cancers, reduced expressions of the E-cadherin, $\beta$-catenin, and c-met proteins may play some role in poorer tumor differentiation, deeper tumor invasion, and increased lymph node metastasis. Also, the c-met gene is thought to play a specific role in the mechanism of the yet unknown catenin action.
Localization using Neural Networks and Push-Pull Estimation based on RSS from AP to Mobile Device
조성진,이승룡,Cho, Seong-Jin,Lee, Sung-Young Korea Information Processing Society 2012 정보처리학회논문지D Vol.19 No.3
글로벌 포지셔닝 시스템(GPS)의 기술이 점점 발전하고 있으나, 그 정확성은 건물의 내부나 지하도로에서의 위치인식이 아닌, 실외에서의 위치인식에서만 적합하다. 건물의 내부나 지하도로에 대한 위치 인식의 응용분야에 대하여, 글로벌 포지셔닝 시스템은 빌딩의 내부나 지하도로에서 정확한 위치인식을 요구 받을 경우, 건축구조물들로 인하여 정확성을 달성할 수 없다. 왜냐하면 사람이 필요로 하는 공간은 건물의 내부나 지하도로에서 수 평방미터에 불과한 매우 작은 공간이기 때문이다. 위치추정에 기반을 둔 수신신호강도(RSS)는 거의 모든 건물과 지하도로에서 수신이 가능한 무선 근거리통신망, IEEE 802.11, WiFi 전파신호 위치추정을 이용한 방안으로서, 특별히, 매우 좋은 선택이 될 수 있다. 이와 같은 위치추정시스템들의 근본적인 필요성은 특정 위치에서 수신신호 강도를 이용하여 통신기지국으로부터 모바일장치에 이르는 위치의 평가를 가능하도록 하는 것이다. 이와 같은 과정에서 발생하는 다중 경로 페이딩 현상들은 위치추정에서 불확실성의 원인으로서, 수신신호강도를 예측하기 어렵게 만든다. 이와 같은 문제들을 해결하기 위하여, 신경망과 푸시-풀 평가 방법의 결합은 건물의 내부나 지하도로에서 모바일장치들을 이용하여 위치의 결정을 학습하고, 결정할 수 있도록 적용된다. Although the development of Global Positioning System (GPS) are more and more mature, its accuracy is just acceptable for outdoor positioning, not positioning for the indoor of building and the underpass. For the positioning application area for the indoor of building and the underpass, GPS even cannot achieve that accuracy because of the construction materials while the requirement for accurate positioning in the indoor of building and the underpass, because a space, a person is necessary, may be very small space with several square meters in the indoor of building and the underpass. The Received Signal Strength (RSS) based localization is becoming a good choice especially for the indoor of building and the underpass scenarios where the WiFi signals of IEEE 802.11, Wireless LAN, are available in almost every indoor of building and the underpass. The fundamental requirement of such localization system is to estimate location from Access Point (AP) to mobile device using RSS at a specific location. The Multi-path fading effects in this process make RSS to fluctuate unpredictably, causing uncertainty in localization. To deal with this problem, the combination for the method of Neural Networks and Push-Pull Estimation is applied so that the carried along the devices can learn and make the decision of position using mobile device where it is in the indoor of building and the underpass.
조성진(Seong Jin Cho),김승태(Seung Tae Kim),임영한(Young Han Lim),김진환(Jin Hwan Kim),황준식(Joon Sik Hwang),노영수(Young Soo Rho) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.1
Objectives: The hepatocyte growth factor(HGF)/c-Met pathway may play various roles in the carcinogenesis of various organs. Although HGF/c-Met signalling pathway has been shown to demonstrate various cellular responses including mitogenic, proliferative, morphogenic and angiogenic activities, the study on their expression related to clinicopathological parameters in thyroid tumor is relatively rare. So we want to find out the clinical significance of the c-Met in thyroid tumor. Materials and Methods: We assess the mRNA and protein expression of the c-Met genes by means of RT-PCR method and the immunohistochemical stain in 100 cases of thyroid tumors(50 papillary carcinomas, 10 follicular carcinomas, 20 follicular adenomas, 20 nodular hyperplasia). Results: By RT-PCR, c-Met mRNA was detected in 43(86%) in papillary carcinoma, 4(40%) in follicular carcinoma, 4(20%) in follicular adenoma and 2(10%) in nodular hyperplasia cases. By immunohistochemistry, c-Met protein expression was detected in 44(88%), 2(20%), 3(15%) and 1(5%). Expression of the c-Met mRNA and protein expression was significantly highly recognized in papillary carcinoma. The c-Met protein overexpression was significantly correlated with the grade of the differentiation. Conclusion: These results suggest that c-Met expression may be associated with thyroid papillary cancer progression. The differential expression of c-Met protein and mRNA suggests that these molecules may be a reliable diagnostic marker in thyroid papillary cancer.
Linear Time Temporal Logic을 이용한 자동 검증을 위한 언어에 관한 연구
조성진(Cho seong jin),최영근(Choi young keun) 한국정보과학회 1988 한국정보과학회 학술발표논문집 Vol.15 No.1
본 논문은 linear time temporal logic(LTTL)을 이용한 자동 검증 시스템의 구현을 제안하며, 이에 대한 한 과정으로서 LTTL 언어인 Tempura에 새로운 기능을 첨가한다. Tempura를 automated verification tool로서 사용하기 위해서는 interleaving model에 대한 nondeterminism이 제공되어야 하며, finite state graph를 generation할 수 있어야 한다. 따라서 본 논문에서는 interleaving model과 그에 따른 synchronization 문제를 해결하며, model checking을 위한 finite state graph를 generation할 수 있도록 Tempura를 확장하는 것에 그 목적을 둔다.
High Contents Screening을 위한 비접촉식 고정밀 디스팬서 제작
조성진(Seong J. Cho),김인태(Intae Kim),임근배(Geunbae Lim) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Nowadays medical treatment service increase due to ageing population and improving the quality of life. Accordingly it is predicted that drug discovery market will expansion continuously. Therefore it is necessary that profit creation by drug discovery on the global market is important. HCS(High Content Screening) has been emerging as a potential method to solve problems of the present drug discovery. This research is about liquid dispenser for HCS. The purpose of this research is to manufacture high performance liquid dispenser for HCS. The liquid dispenser for HCS has to satisfy several conditions; fast, precision dispensing, dispensing of various kind of liquid at once, and being disposable, biocompatible, and chemically inert on the part of contact with liquid. To satisfy these conditions, several works were performed; the pressure driven pump was developed because there were many disadvantages on syringe pump to control very small liquid volume. The dispenser is designed to control 5 liquids separately. HCS system has to use many kinds of liquids and control dilution ratio between liquids. The liquid contact parts are designed disposably, biocompatibly and chemically inertly. Air curtain is equipped at the side of tip to dispense very small liquid volume and to prevent hanging drop on tip. Valving is performed by just controlling the pressure of the pressure driven pump without valve. Therefore, problems occurring while using valve are solved. As a result of these works, liquid dispenser for HCS is completed.