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특발성 폐섬유화증 환자에서 기관지폐포세척액 소견과 생리-방사선-조직학적 진행도와의 상관관계 및 스테로이드 치료에 대한 예후인자와 구성세포 변화에 관한 연구
조상헌 ( S. H. Cho ),이상도 ( S. D. Lee ),권오정 ( O. J. Kwon ),이춘택 ( C. T. Lee ),정희순 ( H. S. Chung ),한성구 ( S. K. Han ),심영수 ( Y. S. Shim ),김건열 ( K. Y. Kim ),한용철 ( Y. C. Han ),함의근 ( E. K. Ham ) 대한결핵 및 호흡기학회 1989 Tuberculosis and Respiratory Diseases Vol.36 No.4
폐결핵환자에서 기관지폐포세척액 및 말초혈액의 임파구 아형에 관한 연구
한성구(S . K . Han),조상헌(S . H . Cho),김준우(J . W . Kim),김영환(Y . W . Kim),심영수(Y . S . Shim),김건열(K . Y . Kim),한용철(Y . C . Han) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A It is known that the helper T-cell subset of T-lymphocyte is decreased in the peripheral blood of tuberculosis patients. To explain this phenomenon, the compartmentalization theroy, suppressor monocyte and clonal expansion theory and others were proposed. To elucidate these phenomenon, we examined the changes of lymphocyte subsets in bronchoalveolar lavage fluid and peripheral blood of pulmonary tuberculosis patients by double bridge technique of alkaline phosphatase-anti-alkaline phosphatase (APAAP) using monoclonal antibodies, and obtained the following results. 1) Total cell count of bronchoalveolar lavage fluid in pulmonary tuberculosis patients was 28±14.5×106 and showed significantly increased value compared with control group of 16.96±10.75×106(P<0.01). The T-lymphocyte percentage ratio to total cell count was 30.11±17.21% in pulmonary tuberculosis patients and it showed significantly increased ratio compared with 6.85±2.11% of control group (p<0.05). 2) Helper T-cell/suppressor T-cell ratio in the peripheral blood of pulmonary tuberculosis patients was 1.32±0.2 and showed significantly lower value compared with 1.58±0.19 of control group (p<0.05). Total T-lymphocyte and helper T-cells were also decreased but not in the magnitude of statistical significance. Suppressor T-cell showed no difference between pulmonary tuberculosis patients and control group. 3) Total T-lymphocyte (mean 64.84%) and helper T-cells (mean 41.9%) in bronchoalveolar lavage fluid of pulmonary tuberculosis patients were significantly increased than the control group of 53.42% and 32.28%. Helper T-cell/suppressor T-cell ratio was 1.9±0.58 in pulmonary tuberculosis patients and 1.5±0.16 in control group with no significant difference (p>0.05). There was no difference of suppressor T-cells of bronchoalveolar lavage fluid between the two comparing groups. 4) In pulmonary tuberculosis patients, total T- lymphocytes (mean 64.84%) and helper T-cells (mean 41.92%) in the bronchoalveolar lavage fluid were significantly increased than in the peripheral blood (44.92% and 27.00%). And helper T-cell/suppressor T-cell ratio (mean 1.92) was also increased in bronchoalveolar lavage fluid than in the peripheral blood (mean 1.32), but suppressor T-cells showed no difference between the bronchoalveolar lavage fluid and peripheral blood.
IgE - 수용체 매개성 호염기구히스타민유리능과 염색체 11q13 유전형 사이의 연관성
김윤근(Y K Kim),조상헌(S H Cho),고영률(Y Y Koh),손지웅(J W Son),민경업(K U Min),김유영(Y Y Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.3
Objective : To evaluate that genetic factor(s) in chromosome 11q13 may control the expression of basophil histamine release (BaHR) after anti-IgE stimuli, linkage analysis between this phenotype and gene marker of chromosome 11q13 was performed. Material and methods : BaHR after anti-IgE stimuli and genotyping chromosome 11q13 using microsatellite marker (D11S97) was performed in 56 probands with asthma and 59 their sibs. The linkage between the phenotype and the genotype was evaluated by affected and quantitative trait locus (QTL) sib-pair analysis. Results : Maximal BaHR after anti-IgE were 43.3±3.5% in probands and 29.5±2.6% in sibs, respectively. Of 20 sib-pairs with the maximal BaHR more than 33%, 11 (55%) shared two D11S97 alleles, 9 (45%) shared one allele, neither sib-pair shared identical allele. The sharing rate of D11S97 alleles was 75.5%, which indicates linkage of the phenotype and the genotype (p= 0.026). Difference of the maximal BaHR between probands and their sibs was smaller in sib-pairs with two identical alleles than in those with one identical allele and with no identical allele (14.1±2.5% vs. 25.8±3.1% vs. 40.9±4.9%). Conclusion : Expression of basophil histamine release after anti-IgE stimuli was linked to gene marker of chromosome 11q13.
직업성천식 감시체계에 등록된 우리나라의 직업성천식 실태
강성규(Seong Kyu Kang),지영구(Young Koo Jee),남동호(Dong Ho Nahm),민경업(Kyung Up Min),박중원(Jung Won Park),박해심(Hae Sim Park),손춘희(Seong Kyu Kang),조상헌(Sang Heon Cho),최인선(In Seon Choi),최승원(Seung Won Choi),홍천수(Chein S 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.6
Background: Since asthma caused by toluene diisocyanate (TDI) was reported at a polyurethane paint factory, occupational asthma there has been increasing concern of in both allergic and occupational health. However, the statistics of occupational asthma did not reflected its seriousness because of many barriers related to legal reporting. Since fild a voluntary report from a clinician sent directly to a surveillance center would allow more cases to be filed without any disadvantage to workers and employers, we developed a surveillance system to facilitate the reporting of occupational asthma. Methods : Allergists and pulmonary physicians were asked to report to the Occupational Asthma Surveillance Center(OASC) using a mail, fax or e-mail if work-related asthma was diagnosed. A claimed case for occupational asthma to the Occupational Health Research Institute was also included. The OASC contacted the workers by phone and investigated the workplace if necessary. The reported cases from October, 1998 to November, 1999 were analysed. Results: Thirty-three cases were reported with 29 males and four females. The mean age was 44 and the mean latency period was 5.4 years. Twenty-one cases were caused by a known allergen inducer with objective evidence. The causative agents included TDI in 45.5 %(15), followed by reactive dye in 24.2 %(8). welding fume(2), formaldehyde(1), paint (1), toluene(1). styrene(1), exhaustive gas(1), and wood dust(1). Among these cases, there were seven dyers, four painters, three machine operators and furniture finishers, two assemblers and tanneries. Eighteen cases had claimed Workers Compensation Insurance and all were accepted. The reasons for not claiming Insurance included ignorance(28.5%), feat of job dismissal (23.8%), other reasons (9.5 %), agreement with the employer(14.3%) and employer hirnself(9.5 %) Conclusion : The OASC by allergists was an effective system to find unreported cases and to provide a prevention strategy of occupational asthma. Occupational asthma was mostly caused by TDI and reactive dye. Painters and dyers were the most common occupations causing occupational asthma. Only half of occupational asthma patients claimed compensation because of workers ignorance and fear of being fired. (J Asthma Allergy Clin Immunol 20: 906-15, 2000)