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계지작약지모탕(桂枝芍藥知母湯)이 Ajuvant 투여로 유발된 풍습성(風濕性) 동물병태모델에 미치는 실험적 연구
정현우,Jeong, Hyun-Woo 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1
The purpose of this study explain the experimental effects of Guizhishaoyaozhimu-Tang (桂枝芍藥知母湯) that have clinical efficacy in rheumatoid Arthritis. Materials of present study were Guizhishaoyaozhimu-Tang freeze dried powder (GSZT), Sprague-dawley rats (300 g or so, male), various kinds of needing experimental studis. In order to study the therapeutic effects of GSZT, this Prescription (GSZT 500 mg/kg, 1,000 mg/kg) were administered per oral to the rats with the arthritis induced by Freund's complete adjuvant ($0.2m{\ell}/kg$), several experimental items were measured and compared each other ; that is body weight, rate of edema, analgesic effect by hot plate method, WBC, total protein, TNF-${\alpha}$, IL-10 and expression and localization of H&E, COX-2 staining in synovial tissues from rat with rheumatoid arthritis by immunohistochemical staining using polyclonal COX-2 antibodies. Rats were divided into four groups. Normal group was not treated with Freund's complete adjuvant and treated with DDW 1.0 $m{\ell}$, Control group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and DDW 1.0 $m{\ell}$, Sample A group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (500 $mg/m{\ell}$) $1.0m{\ell}$, Sample B group was treated with Freund's complete adjuvant 0.2 $m{\ell}/kg$ and GSZT (1,000 $mg/m{\ell}$) 1.0 $m{\ell}$. 0 was day that did not start experiment, 14 was day that confirmed rheumatism induced by Freund's complete adjuvant, 28 was day that completed experiment. The following results were obtained in this study ; Sample A group was increased in body weight, escape time and paw licking time statistical significance compared with Control group, and were decreased in edema, WBC, total protein, TNF-${\alpha}$ with statistical significance compared with Control group. Sample B group was increased in escape time with statistical significance compared with Control group, and were decreased in edema, WBC, total protein with statistical significance compared with Control group. Sample A and Sample B groups were increased in IL-10 compared with Control group, and Sample B group was decreased in TNF-${\alpha}$ compared with Control group. And, Control, Sample A and Sample B groups were showed considerable reduction of positive expression in comparison to Normal group. Especially, Sample B group was most significantly reduction of positive expression than the other groups. From above results, I suggest that GuizhiShaoyaoZhimu-Tang can be used for curing rheumatoid arthritis.
죽력(竹瀝)이 T-lymphocytes 및 복강(腹腔) Macrophage에 미치는 영향(影響)
정현우,강성용,한종현,이원석,오찬호,은재순,Jeong, Hyun-Woo,Kang, Sung-Yong,Han, Jong-Hyun,Lee, Won-Suk,Oh, Chan-Ho,Eun, Jae-Soon 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.2
The purpose of this research was to investigate effects of Bambusae Caulis in Liquamen(BCL) on T-lymphocytes and peritoneal macrophages in mice. The apoptosis and subpopulation of T-lymphocytes were tested using a flow cytometer. The phagocytic activity of mouse peritoneal macrophage was tested using a luminometer. Nitric oxide production was tested using a Griess reagents. BCL induced T-lymphocytes apoptosis. BCL increased $T_H$ cells population and decreased $T_C$ cells population of T-lymphocyte, but did not affect splenocytes subpopulation. BCL increased nitric oxide production and phagocytic activity of peritoneal macrophage in mice. These results suggest that BCL regulates the immune system in consequence of an increase in helper T cell population and macrophages activation.
정현우,염호준,박상수,Jeong, Hyun-Woo,Yeom, Hojun,Park, Sangsoo 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6
Korea's long-term care insurance for the elderly, which started in 2008, is a borrowed one from gaeho insurance, which started eight years earlier. Both countries have a policy of welfare equipment benefit systems to support the lives of the elderly who are intellectually and mentally weakened. In this study, we attempted to compare and examine the welfare equipment items in Korea with those in Japan and find out the characteristics of the items in Korea and Japan. In Korea, loitering-detection device, posture changing devices, and incontinence underwears were registered as welfare devices before Japan, and in Japan, automatic urine disposal systems, wheelchair electric assist device, position converters, and lifts for handicapped person were designated as welfare devices before Korea. In addition, the Japanese Ministry of Health, Labor and Welfare has announced the designation of the excretion prediction support device as a welfare device. If Korea and Japan cooperate to develop welfare equipment items together, it will be of great help in improving the quality of life of the elderly in both countries in a super-aged society.
직접 수열 확산 방식 기반 다중 밴드 FSK 신호의 성능 분석 및 실험 결과
정현우,신지은,정지원,Jeong, Hyun-Woo,Shin, Ji-Eun,Jung, Ji-Won 한국음향학회 2021 韓國音響學會誌 Vol.40 No.4
본 논문에서는 수중 통신에서 은밀성과 성능 향상을 위해 직접 수열 확산 방식 기반 다중 밴드 기법을 사용한 부 대역 Frequency Shift Keying(FSK) 신호의 효율적인 송수신 구조를 제시하였다. 은밀성적인 측면에서는 Pseudo Noise(PN) 부호의 chip을 직접 곱하는 직접 수열 대역 확산 방식을 적용하였으며, 성능적인 측면에서는 다중 경로 특성, 도플러 확산 등으로 인한 성능 감쇠를 극복하기 위해 다중 밴드, 터보 등화, 각 밴드별 가중치 알고리즘을 적용하였다. 시뮬레이션 결과를 바탕으로, 송수신기 사이의 거리가 약 300 m ~ 500 m인 호수에서 기동 실험을 하여 대역확산 신호의 chip 수를 8개, 32개로, 다중 밴드 수는 4개 일 때의 성능을 분석하였으며, chip 수가 증가할수록, 터보 등화 기법 적용 시 반복횟수가 증가할수록 성능이 향상되었고, 다중 밴드에서 프리엠블 오류율을 분석하여 밴드 별 가중치를 적용 시 더 많은 패킷 전송 성공률을 나타냈다.
수종(數種)의 한약재(韓藥材)가 인체(人體) 암세포주(癌細胞柱)에 미치는 세포(細胞) 독성(毒性)
정현우,Jeong, Hyeon-U 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.1
The purpose of this research was to investigate effect of water extract of Euphorbiae Pekinensis Radix and Moutan Cortex Radicis on the proliferation of human cancer cell-lines. The effects of Euphorbiae Pekinensis Radix and Moutan Cortex Radicis on the proliferation of A431, HeLa, MOLT-4, K562 cells, Balb/c 3T3 cells, mouse thymocytes, splenocytes and human lymphocytes were estimated by MTT colorimetric assay. The results were as follows; 1. In proliferation of A431, HeLa, MOLT-4 and K562 cell-lines, Euphorbiae Pekinensis Radix and Moutan Cortex Radicis inhibited the proliferation of K562 cells. 2. In the combined effect of Euphorbiae Pekinensis Radix and mitomycin C, Moutan Cortex Radicis and mitomycin C, all herbs stimulated the proliferation of MOL T-4 cells. 3. Euphorbiae Pekinensis Radix and Moutan Cortex Radicis did not inhibited the proliferation of Balb/c 3T3 cells. 4. Euphorbiae Pekinensis Radix and Moutan Cortex Radicis stimulated the proliferation of mouse thymocytes. 5. Euphorbiae Pekinensis Radix and Moutan Cortex Radicis stimulated the proliferation of mouse splenocytes. 6. Euphorbiae Pekinensis Radix and Moutan Cortex Radicis stimulated the proliferation of human lymphocytes.
수중 음향 통신에서 주파수 편이 변조 신호의 프리엠블 오류율을 이용한 주파수 이득 조절 연구
정현우,정지원,김완진,Jeong, Hyun-Woo,Jung, Ji-Won,Kim, Wan-Jin 한국음향학회 2022 韓國音響學會誌 Vol.41 No.2
The main characteristics of the underwater acoustic channel have varying multipath and fast fading. Especially, Frequency Shift Keying (FSK) signals with multiple frequency bands caused loss of information bits allocated on the specific frequencies due to selective fading phenomenon. Therefore, this paper proposes frequency gain control algorithm based on preamble error rates. The proposed algorithm estimates optimal gain value in the range of preamble error rate with less than 10 % for specific faded frequency. By employing turbo equalized FSK signals with rate of 1/3, the experiment was conducted on a lake in Munkyeong city with distance of 300 m to 500 m. The result confirms that packets are decoded successfully by applying proposed algorithm as increasing number of iterations.