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흰쥐의 염증반응에 대한 CW-501027과 CW-501029의 억제효과
정지훈,심재호,양성준,민영실,송현주,우재광,김용성,조영래,손의동,Jung, Ji-Hoon,Sim, Jae-Ho,Yang, Sung-Jun,Min, Young-Sil,Song, Hyun-Ju,Woo, Jae-Gwang,Kim, Yong-Sung,Cho, Young-Rae,Sohn, Uy-Dong 대한약학회 2004 약학회지 Vol.48 No.6
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. It has been shown that nitric oxide (NO), similar to pro staglandins (PGs), appears to play an important role in gastric mucosal defence. We hypothesized that NSAIDs contained NO group would be less acutely toxic to the gastric mucosa, but would not interfere with their ability to suppress inflammatory process in rats. We have compared the ulcerogenic and anti-inflammatory effect of CW-501029 (NO-NSAIDs), CW-501027 (NSAIDs) and indomethacin. Both did not change mean blood pressure and heart rates, indicating that they had no side effect on cardiovascular system. We found that CW-501029 increased nitrite/nitrate levels without changing of blood pressure and heart rates. We suggest that it may help gastric mucosal blood flow, the which helps reducing the discomfort in astrointestinal system. Carrageenan-induced PGE2 increase was reduced in a similar tendency when compared CW-501027 or CW-501027 with control in back exudate of rats, but CW-501029 less reduced PGE2 than CW-502027 or indomethacin in gastric tissues. CW-501027 or CW-501029 reduced platelet aggregation. From these results we suggest that CW-501029 may improve the side effect by reduction of short-term gastric injury and less inhibition of PGs synthesis.
정지훈 ( Gee-hoon Jung ),강효근 ( Hyo-geun Kang ),김주언 ( Ju-eon Kim ),신재원 ( Jae-won Shin ),홍상택 ( Sang-taek Hong ),박진호 ( Jin-ho Park ),김영종 ( Young-jong Kim ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.1
자연재해나 전쟁 등으로 인한 긴급 구호 상황에서의 환자에 대한 응급처치는 중요하다. 그러나 자연재해나 전쟁으로 인해 지면이 불균형해지면 응급 처치를 하기가 불편해진다. Absolute Table은 테이블, 자이로 센서, 가속도 센서, 초음파 센서, 스텝 모터, 모터 드라이버, 스크류와 너트, 각종 스위치들로 구성되어있다. Absolute Table의 전원을 키면 실시간으로 수평을 맞추고 유지해 평평한 작업대를 형성한다. 어떤 형태든 적용이 가능해 실시간 수평 유지 기술이 필요한 다양한 분야와 접목시킬 수 있을 것으로 예상된다.