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백서에서 유발시킨 역류성 식도염에서 지질 과산화와 Glutathione 의 의미
박효진(Hyo Jin Park),김정환(Jung Hwan Kim),김혜영(Hye Young Kim),정준근(Joon Keun Jung),이상인(Sang In Lee),박인서(In Suh Park) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A The role of oxygen-derived free radicals has been studied in acute gastric and esophageal mucosal injury. Objectives: The aim of this study was to determine whether acid reflux causes oxidative stress in the esophageal mucosa and to investigate the correlation between mucosal glutathione (GSH) levels as an endogenous free radical scavenger and lipid peroxidation. Methods: Eight-week-old male Sprague-Dawley rats with a bodyweight of 250-300 g were used for the experiments. Acid reflux was caused by pyloric ligation. The sham operation included a midline laparotomy and served as controls. After 24 hr all rats were killed and esophageal samples were taken for measurement of gross mucosal injury and mucosal GSH level. Lipid peroxidation which is a marker of oxidative stress was determined by measuring the formation of thiobarbituric acid-reactive substances (TBARS) spectrophotometrically. Results: Severe mucosal damage was noted in reflux group. TBARS level was 6 times greater in reflux group compared to the control group (P<0.05), while GSH level was 4 times less in reflux group compared to the control group (P<0.05). Increase of TBARS level and decrease of GSH level showed a strong correlation to the gross findings of esophageal mucosal damage in reflux esophagitis. Conclusions: Oxygen-derived free radicals are of pathophysiologic importance in esophagitis caused by acid reflux. (Korean Journal of Gastrointestinal Motility 2001;7:175-180)
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이상인,김경철,강진경,문영명,정재복,이세준,정준표,이관식,정준근,신은택 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3
Background/Aims: Biliary cystadenomas and cystadenocarcinomas are rare intrahepatic cystic neo plasms that are pathologically characterized by multilocular appearances. We analyzed the clinical pathologic and radiologic features of these rare diseases. Methods: Nine patients with intrahepatic biliary cystadenoma (n=6) or cystadenocarcinoma (n=3) which was surgically proven were included in this retrospective study. Results: There were 8 women and one man, with the mean age of 41 years (range, 23-60 years). Abdominal pain and/or distension were the major clinical symptoms. The appearance of the tumors was either unilocular cystic or multilocular cystic. The tumors did no communicate with bile ducts. Papillary excrescences, nodular thickening of internal septa and mura nodules were seen in one case of cystadenoma and in all three cases of cystadenocarcinomas. Patho logically, these tumors were typically well-encapsulated and composed of multiple cysts that were lined with biliary type epithelium. After complete resection, all patients except one who had positive lymph nodes did not experience recurrence of tumor. Conclusions: When a well-encapsulated, mul tilocular intrahepatic cystic mass is detected, especially in a middle-aged woman, biliary cystadenoma and cystadenocarcinoma should be suspected and resected.
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