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굴곡성 기관지경을 통한 겸자 생검술과 냉동 생검술의 비교
김재현 ( Jae Hyun Kim ),최정민 ( Jung Min Choi ),송성은 ( Sung Eun Song ),이은미 ( Eun Mi Lee ),이송주 ( Song Ju Lee ),옥철호 ( Chul Ho Oak ),장태원 ( Tae Won Jang ),정만홍 ( Man Hong Jung ),장희경 ( Hee Kyung Jang ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.66 No.2
연구배경: 냉동 생검은 극저온으로 암 조직을 얼려 조직의 괴사를 만들어 검체를 채취할 수 있는데 출혈이 적어서 많은 양의 조직을 한번에 채취할 수 있다는 장점이 있다. 본 연구에서는 기관지 내 병소가 있는 폐암 환자에서 굴곡형 기관지 내시경을 이용하여 겸자 생검과 냉동 생검을 시행하여 얻은 각각의 조직의 특징을 비교하였고 냉동 생검을 시행하여 얻은 조직을 통해 항암제 감수성 검사를 위한 배양 결과 및 혈관 내피 세포 성장인자(vascular endothelial growth factor, VEGF)의 발현 여부를 연구하였다. 방법: 고신대학교 복음병원에서 폐암으로 진단되어 시행한 기관지경에서 용종성 병병이거나 결절형 돌출성병변이 관찰된 환자 30명을 대상으로 하였다. 냉동 생검은 기관지경을 병소에 삽입한 후 먼저 겸자 생검을 시행하였고, 이후 겸자 채널을 통해 냉동 탐침을 삽입하여 병소에 접촉시켰다. -80℃로 8초간 급속 냉동한 후 조직을 떼내어 내시경과 함께 빼낸 뒤 채취하였다. 결과: 겸자 생검 조직과 냉동 생검 조직의 평균 크기는 각각 2.0±1.2 mm, 6.0±3.0 mm였다. 조직의 정확한 진단이 된 경우는 겸자 생검 조직에서 23예(76%), 냉동 생검 조직에서 27예(90%)였다. 겸자 생검에서 확진이 되지 않았던 7예 중 5예에서 진단이 가능하였다. 조직의 분화도 결정은 겸자 생검 조직과 냉동 생검 조직에서 각각 15예, 25예에서 가능하였다. 냉동 생검을 통해 얻은 조직은 총 5예에서 항암제 감수성 검사를 의뢰하였고 전 예에서 배양이 이루어져 적절한 감수성 검사를 시행할 수 있었다. 또한 냉동 생검을 통해 얻은 조직 중 2예에서 VEGF의 발현 정도를 관찰하고 판정할 수 있었다. 결론: 굴곡형 기관지 내시경을 이용한 냉동 조직 생검은 기존의 겸자 생검에 비해 비교적 큰 조직을 얻을 수 있는 안전하고 유용한 방법이 될 수 있을 것이며 또한 항암제 감수성 검사를 위한 검체 확보 및 VEGF의 발현 정도를 관찰하고 판정하는 데에도 도움이 될 것으로 생각된다. Background: A forceps-biopsy is performed to acquire tissue from patients with an endobronchial carcinoma using a flexible bronchoscope. Recently, a cryo-biopsy has also been used to acquire tissue samples. Cryo-biopsy is the diagnostic application of extreme cold for the local destruction of abnormal living tissue. This technique is safe, with no radiation danger, no risk of electrical accidents, and a little risk of bleeding. This study compared a forceps-biopsy with a cryo-biopsy using a flexible bronchoscope, and examined the chemosensitivity and level of VEGF (vascular endothelial growth factor) in the specimens obtained from the cryo-biopsy. Methods: We present a prospective study of 30 consecutive patients who underwent a forceps-biopsy between January 2007 and October 2007 with a mean age of 62.1 years and a male:female ratio of 5:1. A flexible bronchoscope was inserted to the area of the abnormal lesions, and a cryo-probe was then applied through the working channel of the flexible bronchoscope. A temperature of approximately ?80 was delivered to the tumor site for 8 seconds. The cryo-biopsy was performed after destroying the tumor mass. Results: The mean size of the tissue from the forceps-biopsy and cryo-biopsy were 2.0±1.2 mm and 6.0±3.0 mm. A chemosensitivity test was performed on 5 specimens obtained using cryo-biopsy and the level of VEGF was examined in 2 specimens obtained from a cryo-biopsy. There were no side effects in either group. Conclusion: Cryo-biopsy using a flexible bronchoscope is a safe and effective technique for acquiring tissue samples.
장태원(Tae Won Jang),서보원(Bo Won Seo),김중경(Jung Kyung Kim),정만홍(Man Hong Jung),주운수(Woon Soo Joo),한동선(Dong Sun Han),이재우(Jae Woo Lee) 대한내과학회 1989 대한내과학회지 Vol.36 No.5
N/A To evaluate the effect of chronic alcohol ingestion on heart function, we performed a controlled study with 40 alcoholics and 34 non-alcoholics. The alcoholics ingested more than 90 grams of ethanol per day over 10 years, without any symptoms related to heart failure. Left ventricular size, ejection fraction, fractional shortening, LV mass, systolic time intervals, and transmitral flow velocities were measured by non-invasive methods using EKG, phonocardiogram, carotid pulse tracing, M mode and Doppler echocardiography. The results were as follows 1) Average daily alcohol consumption was 144±80.2 g/day of ethanol in alcoholics and 2.7±5.1 g in non- alcoholics. 2) There were no statistically significant differences in the left ventricular dimensions, ejection fraction, fractional shortening, left ventricular mass and systolic time intervals between the 2 groups. 3) Transmitral flow velocity in alcoholics showed an early peak flow velocity (EPFV) and atrial peak flow velocity (APFV) of 45±9cm/sec and 51.7±9cm/sec, and in non-alcoholics, 51.2±11.4 cm/sec and 46.9±9.3 cm/sec, respectively. Early to atrial peak flow velocity ratio (EPFV/APFV) was 0.895±0.245 in alcoholics and 1.135±0.333 in non-alcoholics, which was statistically significant (p<0.005). The results suggest that left ventricular dysfunciton may present in alcoholics before the development of alcoholic cardiomyopathy and that diastolic dysfunction precedes systolic dysfunction.
폐암을 동반한 Angioimmunoblastic Lymphadenopathy with Disproteinemia 1 예
최경희(Kyoung Hi Choi),김종진(Jong Jin Kim),박재후(Jae Who Park),정만홍(Man Hong Jung),박병채(Byung Chae Park),이시래(Si Rhae Lee),천봉권(Bong Kwon Chun),허만하(Man Ha Huh) 대한내과학회 1991 대한내과학회지 Vol.40 No.3
Angioimmunmoblastic lymphadenopathy with disproteinemia (AILD) is a rare lymphoproliferative disorder which is recently described and well characterized clinicopatholgic entity. Malignant transformation, usually to malignant lymphoma, occurs in approximately 20% of patients. The association ot AILD and carcinoma is rare: only 5 cases have been reported in the English literature. The rare association of AILD and carcinoma is probably coincidental; however, the immunological imbalance of AILD could have caused the development of the neoplastic disease. We report here a case of AILD with lung cancer of a 58 year old male patient and review the literature.
김종진(Jong Jin Kim),임정식(Jeong Sik Lim),공덕경(Duck Kyung Gong),최경희(Kyoung Hee Choi),정인권(In Gweon Jung),정만홍(Man Hong Jung),이재우(Jae Woo Lee) 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A The left atrial systolic time intervals and Doppler mitral flow velocity measurements were performed in 28 patients of essential hypertension and in 12 normal controls(Group I). The hypertensive patients were divided into two groups according to the absence (Group II, 12 cases) and the presence (Group III, 16 cases) of the fourth heart sound on phonocardiegram. Left atrial systalic time interva) indices included atrial pre-eiection period (APEP), corrected atrial pre-eiection period (APEEc), atrial eiection time (AET) and the ratio of APEP/AKT. The hypertensive patients with the fourth heart sound had a shorter APEPc (78±9 vs 94±11 ms, P<0.01), a longer AET (168±13 vs 144±11 ms, P<0.01), and a shorter APEPc/AET (0.48±0.08 vs 0.66±0.12, P<0.01). The ratio of mitral peak flow velocity during atrial systole to peak flow veloclty in early diastole (A/E ratio) was signifieantly higher in Group III compared with values in Group II (1.54±0.28 vs 1.29±0.31), as well as there being a significant increase of left ventricular wall thickness (2.88±0.38 vs 2.57±0.34 cm, P<0,05). There were no signilicant differences in the left atrial systolic time intervals and the A/E ratio between Group I and Group II. In concluslon, left atria) systolic time intervals can be a good method in the quantitative assessinent of left atrial function in hypertensive patients with left ventricular hypertrophy.