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포스터 발표 : 간 ; 만성 B형 간염환자에서의 라미부딘 단독치료의 효과
김광진 ( Kwang Jin Kim ),신우원 ( Woo Won Shin ),정동엽 ( Dong Yup Jung ),조정환 ( Jung Hwan Jo ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최석렬 ( Seok Ryeol Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 라미부딘은 뉴클레오사이드 유도체로서 B형 간염바이러스의 증식을 억제하여 간기능과 조직학적 소견의 혼전을 일으키는 것으로 알려져 있다. 투약의 간편성과 부작용이 별로 없다는 장점이 있으나, 일부에서 약제 내성이 유발된다는 단점이 있다. 본 연구는 만성B형 간염환자들에서 라미부딘 단독투여로 치료효과와 내성 발생을 및 각각의 예측인자에 대해서 알아보기로 하였다. 〈대상과 방법〉 동아의대 동아대학교병원에 내원하여 만성 B형 간염을 진단받은 환자들 중
라미부딘 장기투여 중 발생한 B 형 간염 바이러스 YMDD 영역의 유전자변이
이종훈(Jong Hun Lee),신우원(Woo Won Shin),안현숙(Hyun Sook Ahn),성명식(Myung Sik Seong),조정환(Jeong Hwan Cho),정동엽(Dong Yup Jung),강기태(Ki Tae Kang),김병희(Byung Hee Kim),노명환(Myung Hwan Roh),한상영(Sang Young Han),최석렬(Seok 대한내과학회 2001 대한내과학회지 Vol.61 No.4
Background: The emergence of YIDD or YVDD mutant hepatitis B virus (HBV), with point mutation in the YMDD motif of DNA polymerase gene, has been reported in patient s with lamivudine treatment group. The aims of this study was to investigate the emergence of mutant HBV during long-term lamivudine therapy using nested polymerase chain reaction (PCR) method and direct DNA sequencing. Methods: Twenty-one chronic hepatitis B patients with HBeAg and HBV DNA positive were evaluated. During lamivudine therapy, there were reported breakthroughs of HBV DNA (over 50pg/mL) when investigated the emergence of YMDD mutants by nested PCR method using restriction fragment length polymorphism (RFLP) in all patients. Direct DNA sequencing of HBV DNA polymerase gene including YMDD motif was also performed. Results: There were 13 patients (61.9%) with YIDD mutant and 8 patients (38.1%) with YVDD mutant. The result s of direct DNA sequencing were consistent with those of nested PCR data based on RFLP. The breakthrough was occurred at 15 to 106 weeks (57.9±23.6). At the point of breakthrough, the level of ALT was 74.8±117.7 (14-546) IU/L, and it was lower than the level of ALT before the therapy. Conclusion: In the long-term therapy of lamivudine, the emergence of YMDD motif mutant HBV was related to the breakthrough of HBV DNA and YIDD mutant was frequent. The nested PCR method using RFLP may be simple and sensitive to detect the YMDD motif mutant HBV. (Korean J Med 61:374-383, 2001)