유전계보학 활용의 법적 함의

정규원,정규원 경찰대학 범죄수사연구원 2022 범죄수사학연구 Vol.8 No.1

With the progress of scientific technology in the field of genetics, the genetic information for use has been expanded and widely used for various purposes in many fields. Genetic genealogy is the use of DNA testing in combination with traditional genealogy methods to infer genetic relationships between individuals. This is currently used for not only inferring biological ancestors in their pedigree in research but also kinship testing and forensic investigation in practices. With the growing industry of DTC services, genetic genealogy is expanding, which proved its promising use by playing an important role in solving multiple cold cases in the US. However it was revealed that there were legal and ethical issues in the process regarding the control and use of genetic information generated with the informed consent of the purpose of the specific service. This situation made the discussion on issues related to the use of genetic genealogy and legal regulation in the US. In Korea, the situation is not such severe possibly due to a gap of genetic data available in countries. However, it is unpredictable for further application regarding the possible range of genetic information for use in genetic genealogy with highly advanced techniques in the future. Therefore, it is important to discuss possible risk and countermeasures able to be taken in advance. Here, we reviewed the precedent cases with potential issues in other countries, and discussed the current system in Korea. It is very important to continue discussing how to protect private information and genetic privacy, and to consider the advanced level of science and technology at the time of the discussion.

"생명윤리및안전에관한법률안"에 대한 검토

정규원 법과사회이론연구회 2002 법과 사회 Vol.22 No.-

만성 간질환의 미세구조 : 과학현미경에서 전자현미경까지 From light to electron microscopy

정규원 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.1

Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015

정규원,원영주,공현주,이은숙,The Community of Population-Based Regional Cancer Registries 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2

Purpose This study presents the 2015 nationwide cancer statistics in Korea, including the incidence, survival, prevalence, and mortality. Materials and Methods Cancer incidence data from 1999 to 2015 was obtained from the Korea National Cancer Incidence Database and followed until December 31, 2016. Mortality data from 1983 to 2015 were obtained from Statistics Korea. The prevalence was defined as the number of cancer patients alive on January 1, 2016, among all cancer patients diagnosed since 1999. Crude and age-standardized rates (ASRs) for incidence, mortality and prevalence and 5-year relative survivals were also calculated. Results Herein, 214,701 and 76,855 Koreans were newly diagnosed and died from cancer in 2015, respectively. The ASRs for cancer incidence and mortality in 2015 were 258.9 and 82.0 per 100,000, respectively. The overall cancer incidence rate has increased significantly by 3.4% annually from 1999 to 2012, and started to decrease after 2012 (2012-2015, annual percent change, –6.1%). However, the overall cancer mortality has decreased 2.7% annually since 2002. The 5-year relative survival rate for patients diagnosed with cancer between 2011 and 2015 was 70.7%, an improvement from the 41.2% for patients diagnosed between 1993 and 1995. Conclusion Age-standardized cancer incidence rates have decreased since 2012 and mortality rates have declined since 2002; however, the 5-year survival rates have improved remarkably from 1993-1995 to 2011-2015 in Korea.

상부위장관출혈의 내시경학적 진단

정규원,정환국,선희식,노재철 대한소화기학회 1977 대한소화기학회지 Vol.9 No.1

Among 1,526 cases performed gastrofiberscopy, 141 patients of upper gastrointestinal bleeding who were admitted to the Department of Internal Medicine, St. Marys Hospital of Catholic Kfedical College during the past 2 years 2 and 6 months from March l, 1974 to September 6,. 1976 were clinically observed. The results were as follows: 1. The incidence of upper gastrointestinal bleeding among 1,526 cases performed gastrofiber copy was 9.2%. The sex distribution was 114 in male and 27 in female with a mean age of 4b. The ratio of male to female was 4. 2: 1. 2. The sources of bleeding were gastric ulcer (27.7%), duodenal ulcer (17.7%), gastric carcnoima (17%) rupture of esophageal varices (13.5%), erosive gastritis (12. 1%), gastroducdenitis (3.5%), miscel Janeous (5.7%), and unknown origin (2.1%) in order. 3. The endoscopic accuracy in patients with upper gastrointestinal bleeding was gastric ulcer CG9. 2%3, gastric carcinoma (96.0%), erosive gastritis (88.2%) 3, and duodenal ulcer, gastroauodenitis, and rupture of esophageal varices were 100%. 4. The success rates in identifving the site of bleeding in relation to time of endoscopy after upper gastrointestinal bleeding were 63.2% within 24 houss, 47.1% in 24-48 hours, 17.6% in 48 72 hours, and 6.3% after 7 days. The success rate fell with increasing time after upper gastrointestinal bleeding. 5. The presence of more than one source of upper gastrointestinal bleeding site was found much in cur patients. The early endoscopy was more reliable than radiology for determining the origin of upper gastrointestinal bleeding, and multiple lesions were found only by endoscopic examination. 6. Complication of endoscopy for the diagnosis of upper gastrointestinal bleeding was 2 out of 141 cases (l.4%) one was arterial bleeding from the lesion of gastric biopsy and the other was aggravation of gastric ulcer bleeding. Both of these was reversible.

원기둥형 물체의 자세 인식 방법

정규원 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

A cylindrical shape object is widely used as a mechanical part and a water pipe or an oil pipeline which are of cylindrical shape are widely used in the infrastructure. In order to handling such objects automatically using a robot, the posture i.e. orientation in 3D space should be recognized. However, since there is no edge or vertex in the pipe, it is very difficult task for the robot. In this paper in order to guide the robot, two kind of algorithms which find the axis using the measured range data from the robot to the object surface are to be developed. The algorithms are verified using both the simulated range data and the measured one.

Prediction of Cancer Incidence and Mortality in Korea, 2020

정규원,원영주,홍세리,공현주,이은숙 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

Purpose This study aimed to report the projected cancer incidence and mortality for the year 2020 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2017 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2018 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years and then by multiplying the projected age-specific rates by the age-specific population. A Joinpoint regression model was used to determine the year in which the linear trend changed significantly; we only used the data of the latest trend. Results In total, 243,263 new cancer cases and 80,546 cancer deaths are expected to occur in Korea in 2020. The most common cancer site is expected to be the lung, followed by the stomach, thyroid, colon/rectum, and breast. These five cancers types are expected to represent half of the overall burden of cancer in Korea. The most common type of cancer among people who die is expected to be lung cancer, followed by liver, colon/rectal, pancreatic, and stomach cancers. Conclusion The incidence rates for all types of cancer in Korea are estimated to decrease gradually. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluating cancer-control programs.

인체 유래 생물학적 물질의 소유권 - 사체를 중심으로 -

정규원,Jung, Kyu Won 대한의료법학회 2017 의료법학 Vol.18 No.1

전통적인 법이론에 의하여 인간은 권리의 주체이기 때문에 인체로부터 유래한 생물학적 물질은 권리의 객체가 될 수 없다. 하지만 의학과 생명과학의 발전으로 인하여 인체로 부터 유래한 생물학적 물질은 다양한 용도로 사용되고 있으며 인체로부터 유래한 생물학적 물질의 객체성 여부와 소유권 인정 여부에 대한 논의는 지속적으로 제기되고 있다. 인체로부터 유래한 생물학적 물질을 법적으로 파악하는 이론은 전통적으로 자율성에 근거한 모델이었으며 현재도 그것이 가장 보편적으로 받아들여지고 있다. 하지만 자율성 모델에 의하여 인체로부터 유래한 생물학적 물질을 파악할 경우 인체로부터 유래한 생물학적 물질을 다루는 현실을 제대로 설명할 수 없을 뿐만 아니라 오히려 배분적 정의의 측면에서 볼 때 적절하지 못한 결론에 도달할 수도 있다는 의문이 제기되고 있다. 인체 유래 생물학적 물질을 소유권의 객체로 파악하려는 소유권 모델은 인간의 존엄과 가치에 반하는 이론 구성이라는 의혹을 받고 있다. 하지만 소유권은 단일한 권리가 아니며 다양한 권리들의 집합체이며 그 내용이 어떻게 구성될 것인가는 객체의 특성 등을 고려하여 판단하면 될 것으로 생각된다. 본 논문은 인체 유래 생물학적 물질의 소유권 전체 보다는 일단 사체로부터 유래한 물질의 소유권 인정 여부를 중점적으로 다루었다. 이를 통하여 인체 유래 생물학적 물질전반에 대한 법이론적 고찰이 현재의 과학적 사실에 적합한 형태로 이루어지기를 기대한다. Ownership is the bundle of rights that allow a person or institute to use and control an object. As the biomedical science is advanced, we should consider whether human biological material should be recognized as property. Whether separated parts of the human body can be objects of ownership is a different issue. Many thought that separated parts of the human body could not be objects of ownership. This idea is primarily based on this thought: even if a piece of human biological material is separated from a person, it still relates to that person, and if treated as a thing, human dignity may be harmed. However, some commentators have admitted separated parts of the human body into the realm of property. Though a person owns his/her body or body parts, this does not mean that he/she can do anything he/she desires. There are many natural and social limitations to exercise the ownership of human biological material as discussed above. Human dignity is the core consideration whether or not we recognize that ownership of human biological material biomedical research and knowledge.

Prediction of Cancer Incidence and Mortality in Korea, 2018

정규원,원영주,공현주,이은숙 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2

Purpose This study aimed to report on cancer incidence and mortality for the year 2018 to estimate Korea’s current cancer burden. Materials and Methods Cancer incidence data from 1999 to 2015 were obtained from the Korea National Cancer Incidence Database, and cancer mortality data from 1993 to 2016 were acquired from Statistics Korea. Cancer incidence and mortality were projected by fitting a linear regression model to observed age-specific cancer rates against observed years, then multiplying the projected age-specific rates by the age-specific population. The Joinpoint regression model was used to determine at which year the linear trend changed significantly, we only used the data of the latest trend. Results A total of 204,909 new cancer cases and 82,155 cancer deaths are expected to occur in Korea in 2018. The most common cancer sites were lung, followed by stomach, colorectal, breast and liver. These five cancers represent half of the overall burden of cancer in Korea. For mortality, the most common sites were lung cancer, followed by liver, colorectal, stomach and pancreas. Conclusion The incidence rate of all cancer in Korea are estimated to decrease gradually, mainly due to decrease of thyroid cancer. These up-to-date estimates of the cancer burden in Korea could be an important resource for planning and evaluation of cancer-control programs.

만성간질환의 미세구조 : 리소솜과 리소솜저장병 Lysosomes and Lysosomal Storage Diseases

정규원 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.4