자연발생 또는 백신접종후 생긴 HBsAg에 대한 항체의 지속성과 Anamnestic Response

정환국,선희식,정규원,노재철,김부성,Chung, Whan-Kook,Sun, Hee-Sik,Chung, Kyu-Won,Ro, Jae-Chul,Kim, Boo-Sung 대한예방의학회 1987 Journal of Preventive Medicine and Public Health Vol.20 No.2

For evaluating the boosting (anamnestic) effects of the most recent commercially produced plasma derived heat-inactivated hepatitis B vaccine (A. Co.), 117 adults with naturally acquired antibody to hepatitis B surface antigen (anti-HBs) were selected at random. In addition, out of case immunized at zero and 1 month, and boosted at 6 months (primary boosting) by conventional vaccine (B. Co), inactivated by pepsin digestion and formalin treatment, 11 cases who showed elevated titer after primary boosting were also submitted to the study. The results were as follows: 1) Out of the 117 subjects with naturally acquired anti-HBs, 6(5.1%) showed isolated anti-HBs and the titers were below 10 ratio units (RU). Negative seroconversion was seen in 4(3.4%) of the 117 cases at 12 months after the screening and, of these cases, 3 showed isolated anti-HBs and the titers were below 10 RU. 2) Eighty-three percent of the cases with naturally acquired isolated anti-HBs below 10 RU did not respond to a booster injection with 3 us dose of A. Co. vaccine at all, but 90% of the other subjects responded. 3) The anti-HBs titers of all the 11 cases who showed a rise of more than 10 RU (increased GMT, 28.04) at one month after primary booster injection by $20{\mu}g$ dose of B. Co. vaccine decreased at 19 months after the primary booster. And 3 subjects (27.3%) of the 11 reached negative seroconversion. All of the 11 cases, who had secondary booster injection with $3{\mu}g$ dose of A. Co. vaccine at 19 months after primary boosting, showed increased anti-HBs titer at least 20 RU or more (increased GMT, 57. 72) at one month after the boosting. According to the above results in the anti-HBs screening survey for the purpose of immunization with hepatitis B vaccine, subjects with isolated anti-HBs below 10 RU should be regarded as being in an unimmunized state. In cases who are in risk circumstances, immunized primarily with a $20{\mu}g$ dose of B. Co. vaccine, a secondary booster injection should be given within 2 years after initiation of primary immunization and a $3{\mu}g$ booster dose of A. Co. vaccine can be reliably used.

‘寃鬼’와 金鰲新話 -조선초 寃魂敍事의 형성

정환국 동양한문학회 2012 동양한문학회 학술발표대회 Vol.2012 No.-

이른바 죽은 귀신, 또는 혼은 ‘人鬼交歡’이라는 형태로, 한국서사문학사의 첫 장면을 화려하게 장식한 소재다. 얼른 들어도 [首揷石枏], [桃花女 鼻荊郞], [崔致遠] 등이 떠오른다. 귀신이 인간사회에 현현한다는 이 소재는 사람이 다른 異類로 변하는 변신 모티프와 짝을 이뤄, 초기 지괴와 전기의 서사 근간을 구축하였다. 문제는 이 소재가 초기서사에만 한정되 지 않고 그 후로도 간단없는 흥미소로 변주되어 왔다는 점이다. 또한 귀신의 실체가 대개 원한 맺힌 寃鬼라는 점에서 심중한 이해를 요구한다. 이 원귀 출현의 서사는 지괴·전기라는 장르관습의 한 소산이기도 하지만, 당대 사회와 인간에 대한 메타포로 해석될 가능성이 크다. 이런 서사의 전통에서, 특히 조전전중기 傳奇小說과 夢遊錄은 이 변주의 정점에 있었다.

한국 고전해양문학의 정위(正位)와 기대지평

정환국 동국대학교 한국문학연구소 2022 한국문학연구 Vol.- No.68

The purpose of this article is to categorize the correct position of Korean traditional Maritime literature as a subordinate category in Korean classical literature. In order to conduct this study, we predicted the expected horizon of further research in the field along with pending issues such as the field of view and data expansion. Korean classical maritime literature has become the subject of research since the 1990s. However, it was limited to a few literary work or drift records. Moreover, its definition, category, and personality have not been clarified. I have formerly explored the possibility of Korean classical marine literature in the reflux of East Asian land and marine culture. As an extension, in order to overcome the monotony of classical literature research and to share that the imagination and desire of the marine zone are important components of Korean culture, the perspective of access to the field, data expansion, and overall layer reconstruction were presented. In particular, the most urgent issue for the united image of classical marine literature is the expansion of data, which is the need to discover and organize the data beyond genre. Following the data expansion, the types were organized in four layers, which includes the emotion of life in the marine zone, the realization of desire, and the reconstruction of totality. In addition, it was confirmed that there was a change in interest and perception of the sea by the writers in the late Joseon Dynasty, while the new possibilities of classical marine literature was realized with the case of drift records, such an interesting narrative tradition related to the sea. Finally, the expected prospects of further research in this field was predicted as classical literature research, realization of Korean literary geography, and composition of Korean maritime literature history. 이 글은 고전해양문학의 정위(正位)를 재범주화 하여 한국 고전문학의 하위 분야로 정초하기 위한 논의이다. 이를 위해 연구의 시야와 자료 확충 등의 현안과 함께 향후 해당 분야 연구의 기대지평까지 전망한 것이다. 고전해양문학은 1990년대부터 연구의 대상이 되기 시작했으나 그 대상이 몇몇 작품이나 표해록에 한정되었다. 거기에 정의와 범주, 성격 등도 명확하지 못한 채 지금에 이르렀다. 필자는 이미 동아시아 육지문화와 해양문화의 환류성(還流性) 속에서 한국 고전해양문학의 가능성을 타진한 바 있다. 그 연장선상에서 고전문학 연구의 단선성을 극복하기 위해, 또 해양지대의 상상과 욕망도 엄연한 한국문화의 중요한 구성 요소임을 공유하는 차원에서 해당 분야에 대한 접근의 시각, 자료의 확충, 전면적인 층위의 재구성 등을 제시하였다. 특히 고전해양문학의 전체상을 위해서 가장 시급한 현안이 자료의 확충인데, 장르를 넘어선 해당 자료의 전면적인 발굴과 정리의 필요성이다. 이런 자료 확충의 기반 아래 그 유형을 네 가지 층위로 상정하였다. 즉 해양지대의 삶과 정감, 욕망의 구현, 총체성의 재구성 등이다. 또한 조선후기 창작주체들의 해양에 대한 관심과 인식의 변화가 있었음을 확인하고, 해양과 관련하여 흥미로운 서사 전통인 표류담의 사례를 가지고 고전해양문학의 새로운 가능성을 짚어 보았다. 마지막으로 향후 이 분야 연구의 기대지평을 고전문학 연구, 한국 문학지리학의 실현, 한국해양문학사의 구성 등으로 전망하였다.

초기 서사에서의 '신이성(新異性)' : 『삼국유사』의 신이 구조 THE MYTHICAL AND STRANGE STRUCTURE OF 「SAM-GUK-YU-SA」

정환국 민족문학사학회 2006 민족문학사연구 Vol.31 No.-

간암발생과 환경

정환국 大韓消化器病學會 1980 大韓消化器病學會誌 Vol.12 No.2

한국(韓國)에 만연(蔓延)하고 있는 만성간염(慢性肝炎)의 자연병력(自然病歷)

정환국,Chung, Whan-Kook 한국생명보험의학회 1985 保險醫學會誌 Vol.2 No.1

Korea is an endemic area of chronic hepatitis in the world. Liver cirrhosis and liver cell carcinoma, presumed to be related to such chronic hepatitis, are the major causes of death in this country. The purpose of this study is disclosing the sources of chronic hepatitis in Korea establishing its histologic characteristics, disclosing the patterns of progression in chronic hepatitis, delineating its prognosis and finally speculating its etiology. The study group was composed of 183 patients with biopsy-proven acute icteric viral hepaticis, 32 patients with biopsy- proven anicteric hepatitis and 260 patients with biopsy- proven chronic hepatitis. These patients submitted to long-term follow-up by means of liver needle biopsy and/or clinicolaboratory evaluation. The period of follow-up ranged from two months to 18 years. The histological features of the initial biopsy specimens of chronic hepatitis permitted a division of the cases cases into the following five types: Type I. Persisting portal hepatitis : so called persisting hepatitis 43 Type II. Chronic inactive hepatitis with incomplete strand septal fibrosis. This type has thin fibrotic septation in addition to Type I with portal sclerosis 38 Type III. Chronic active periportal hepatitis(CAPH) : so called aggressive hepatitis, characterized by marked piecemeal necrosis. This type has been subdivided further into three groups: AB and C on the basis of histologic features. A CAPH without cirrhosis 15 B CAPH with cirrhosis 99 C CAPH with diffuse acinus type parenchymal nodules; characterized by rosette-forming micronodules 21 Type IV. Subacute hepatic necrosis; characterized by multilobular and/or bridging necrosis. 14 Type V. Persisting lobular hepatitis; characterized by spotty necrosis, which looks very similar to acute viral hepatitis. Such histologic changes should be persisted for more than six months 30 In Korea the main source of chronic hepatitis is the anicteric type. Of the chronic hepatitis observed in the hospital, Type IIIb was the most frequent in its incidence and occasionally exhibited development of hepatocellular carcinoma, but the mortality was highest in Type IIIc during the period of follow-up. Histologic characteristics of these five types suggest a spectrum of chronic hepatitis in Korea from an early and mild stage to advanced and fatal cirrhosis, which is occasionally associated with primary hepatic cell carcinoma. It seems that Type IV can be followed by flare-up of various stages of acute and chronic hepatitis with HBsAg and that many cases of liver cirrhosis prevalent in Korea occur through such an active process of Type IV. The etiology is not established, but in Korea it is mainly related to HBsAg.

허균(許筠)의 독서와 문학

정환국 강원대학교 강원문화연구소 2016 강원문화연구 Vol.35 No.-

한국간질환의 특성

정환국 한국만성질환관리협회 1990 월간성인병 Vol.118 No.-

특집종설 / 한국인에 있어서의 간경변증 : 간경변의 진단

정환국 대한내과학회 1974 대한내과학회지 Vol.17 No.8

특집종설 / 수술후에 일어나는 내과적 제문제 : 담낭절제후 증후군

정환국 대한내과학회 1974 대한내과학회지 Vol.17 No.2