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연구보고 : CREST 증후군에 동반된 폐고혈압 환자에서 총상병변내 내피세포 증식의 클론성에 관한 연구
이상도 ( Sang Do Lee ),전용감 ( Yong Gam Jeon ),이지현 ( Ji Hyun Lee ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),고윤석 ( Yun Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won Dong Kim ),( Rubin M. 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.2
실험적 급성 폐색전증에서 Endothelin 수용체 길항제가 혈류 및 호흡 역학에 미치는 영향
이지현 ( Ji Hyun Lee ),전용감 ( Yong Gam Jeon ),최강현 ( Kang Hyeon Choe ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong Soon Kim ),김원동 ( Won Dong Kim ),이상도 ( 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.48 No.2
호흡기 ; 특발성 폐섬유증 환자에서 폐 섬유모세포 증식의 클론성에 관한 연구
이재승 ( Jae Seung Lee ),전용감 ( Yong Gam Jeon ),이상도 ( Sang Do Lee ) 대한내과학회 2010 대한내과학회지 Vol.79 No.1
Background/Aims: Idiopathic pulmonary fibrosis (IPF) is defined pathologically by usual interstitial pneumonia (UIP), and contains characteristic discrete areas of fibroblasts, myofibroblasts, and newly formed collagen, termed fibroblast foci. A new hypothesis postulates that IPF results from epithelial injury and abnormal wound repair without preceding chronic inflammation. We explored the hypothesis that fibroblasts in the fibroblast foci of IPF undergo neoplastic monoclonal proliferation rather than reactive polyclonal proliferation. Methods: We obtained fibroblasts from 24 fibroblast foci in seven female patients with IPF, endothelial cells from ten plexiform lesions of two female patients with idiopathic pulmonary arterial hypertension (IPAH) as a positive control for monoclonality, and lung parenchymal cells by microdissection of each formalin-fixed paraffin-embedded block of lung. To analyze clonality, we performed the human androgen-receptor gene methylation assay (HUMARA). DNA released by protein K digestion was subjected to polymerase chain reaction (PCR) amplification with prior digestion with and without the methylation-sensitive restriction enzyme HhaI. Then, we calculated the clonality ratio after electrophoretic analysis of the PCR amplification product. A clonality ratio <0.25 was considered evidence of monoclonal proliferation. Results: All of the patients included, i.e., the seven females with IPF and the two females with IPAH, showed polymorphism in the human androgen-receptor gene. The mean clonality ratio of the 24 fibroblast foci was 0.70 (SD: 0.18). All of the fibroblast foci had clonality ratios >0.25, suggesting polyclonality, whereas 7 of 10 plexiform lesions had clonality ratios <0.25 suggesting monoclonality. Conclusions: The polyclonality of the fibroblast foci in IPF suggests that the fibroblast proliferation in IPF is not neoplastic, but is reactive in nature. (Korean J Med 79:32-40, 2010)