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FK506에 의한 Jurkat 세포자멸사 유전자 발현분석
장태영(Tae Young Jang),이재숙(Jae Sook Lee),우고운(Go Woon Woo),김현철(Hyun Chul Kim),이호균(Ho Kyun Lee),정상영(Sang Young Chung) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.4
Purpose: FK506 (tacrolimus) is a widely used immunosuppressive agent in the treatment of various medical conditions, including autoimmune disease, bone marrow and organ transplantations. Previously FK506 was known to cause apoptotic death of human Jurkat T cells. Methods: The current study was designed to analyze the gene expression pattern of Jurkat T cells after FK506 application by using cDNA microarray. Treatment of Jurkat T cells with FK506 resulted in a decrease of cell viability in a time- and dose-dependent manner. Next, total RNA of Jurkat T cells was extracted by using TRIzol reagent and used to carry out a confirmation test for the purity and integrity of total RNA. Results: Gene expression levels related to apoptosis and cell cycle process were mainly focused to analyze in FK506-treated Jurkat T cells. According to the inhibition of calcineurin activity, MARCKS in PKC substrates and Sp3 transcription factor was markedly increased in FK506-treated cells. Also, cell cycle control gene Id1 and Id3 were induced in expression from FK506-treated Jurkat T cells. However, FK506 decreased the expression of Src homology 2, G protein, and MEK 2 genes in bioactive peptide induced signaling pathway. It also reduced the expression level of the insulin receptor, DRPLA and Bai1-associated protein 2 genes, which are involved in the regulation of cell motility and morphology control. Conclusion: The author will continue to pursue the exact functional roles of genes that are markedly changed in expression by FK506 in human Jurkat T cells in vitro and in vivo experimental models.
장태영 ( Tae Young Jang ),최종철 ( Jong Cheol Choi ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.1
Background: In previous studies, pH of nasal cavity has a direct effect on the activity of mucociliary transport and nasal secretory protein of the nasal mucosa. More recent studies have reported the normal nasal mucosal pH to be within the range of 6.8 to 7.0 and nasal mucosal pH in infective rhinitis to be within the range of 7.2 to 8.3. However, previous studies have not focused on factors for pH value in the nasal cavitys and they have measured pH value of nasal mucosa by direct methods. There have been a few studies on pH value of nasal mucosa with allergy. Objective: For objectiveness and reproducibility, this study was designed to evaluate the pH value of nasal secretion by the latest trend pH measured method and to analyze the potential variability of pH value of nasal secretion according to changes of nasal symptoms in patients with allergy. Method: All patients in this study were diagnosed with allergic rhinitis by using 2 allergens, Dermatophagoides farinae (Df) and Dermatophagoides pteronyssinus (Dp). They were treated only with avoidance of the offending allergens, and their symptomatic improvement was evaluated through questionnaires at the 3-week follow-up. This study included 30 AR patients with symptomatic improvement (Group 1) and another 30 AR patients without (Group 2). For pH analysis, nasal secretion was obtained by the filter paper absorption method and estimated pH value of nasal secretion with a pH meter using a micro pH electrode. Measurement was repeated at the first and second visits (after 3 weeks of follow-up) and compared the results of pH value between groups 1 and 2. Result: The pH values of nasal secretion were higher in groups 1 and 2 than in normal nasal mucosa from a previous report. The pH values of nasal secretion showed a significant difference between the first and second visits in Group 1 (P<0.01). However, there were no significant difference in pH value between the first and second visits in Group 2. Conclusion: The pH value of nasal secretion is higher AR patients than in normal subjects, results suggest and it differed according to nasal symptoms. These that the pH value of nasal secretion may be a useful parameter for monitoring the conditions of nasal mucosal status and nasal symptoms in AR patients. Further studies with histopathological evaluation are need to enfirm our results. (Korean J Asthma Allergy Clin Immunol 2009;29:39-45)
스케일에 강인한 곡률 특징 벡터를 활용한 실시간 손 모양 분류 기법
장태영(Tae Young Jang),강성현(Seong Hyeon Kang),박현우(Hyun Woo Park),김성대(Seong Dae Kim) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6
Hand shape classification is an important problem for the human computer interaction and the fingerspelling recognition. These problems need a real-time process and scale invariance. To this end, we propose a feature vector for hand shape classification which is fast, and robust to scale. The proposed method calculates an adaptive k-curvature which computes a curvature depending on the hand size. The proposed method works at 0.08sec per image and has a 99% accuracy.