http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
마이크로네시아에 서식하는 해조류 Pylaiella littoralis 추출물의 항산화 효과
예보람,장지이,권영경,전선미,정주영,강도형,오철홍,김지형,Abu Affan,현정호,허수진 한국해양과학기술원 2012 Ocean and Polar Research Vol.34 No.3
Pylaiella littoralis was collected in the Chuuk lagoon of the Federated States of Micronesia(FSM). The FSM has a variety of coral reef ecosystems, which provide essential materials, such asminerals, vitamins, essential amino acids, for marine organisms. In this study, the antioxidant activities ofethanol and enzymatic extracts of P. littoralis were evaluated by measuring their scavenging activities onDPPH free radical, Alkyl radical, hydroxyl radical and cell viability. The enzymatic extracts werehydrolyzed to prepare water soluble extracts by using five carbohydrate degrading enzymes (AMG,Celluclast, Termamyl, Ultraflo, and Viscozyme) and five proteases (Alcalase, Flavourzyme, Kojizyme,Neutrase, and Protamex). As a result, the enzymatic extracts prepared by Flavourzyme, Ultraflo, andKojizyme exhibited the greatest effects in DPPH free radical, alkyl radical scavenging activity and cellviability. Also, these enzymatic extracts had a higher antioxidant effect then commercial antioxidants inDPPH free radical and Alkyl radical scavenging activity. This study suggests that P. littoralis might be auseful source of natural antioxidants for the development of dietary supplements.
예보람,김준성,김민선,장지이,오철홍,강도형,Zhong-Ji Qian,정원교,최일환,허수진 한국해양과학기술원 2013 Ocean science journal Vol.48 No.4
We demonstrated that an extract from Pylaiella littoralis, collected from the Federate States of Micronesia (FSM), could inhibit the proliferation of tumor cells. P. littoralis extract (PLE) showed anti-proliferative activities in the tumorigenic cells tested, ranging from 20.2% to 67.9%. The highest inhibitory activity, in HT-29 cells, was selected for further experiments. PLE showed no cytotoxic effect in normal cells and inhibited the growt of HT-29 cells depending on concentration and incubation time. PLE-treated HT-29 cells showed the typical morphological characteristics of apoptosis, such as apoptotic body formation and DNA fragmentation. PLE also induced mitochondrial membrane potential depolarization and resulted in increased mitochondrial membrane permeability, compared with untreated cells. PLE decreased Bcl-2 protein and increased Bax protein expression, activating caspase-3 and poly (ADP-ribose) polymerase (PARP) expression via the caspase pathway. PLE also increased the phosphorylation of c-Jun N-termial kinase (JNK), p38, and extracellular signal-regulated kinase (ERK), and it reduced cell viability in treatment cells with specific inhibitors such as PD98059 (a specific inhibitor of ERK), SP600125 (a specific inbibitor of JNK), and SB 203580 (a specific inbibitor of p38 MAPK). via the the mitogen-activated protein kinases (MAPKs) pathway. These results suggest that PLE inhibits the proliferation of HT-29 cells by affecting the caspase and MAPK pathways involved in the induction of apoptosis. Thus, we suggest that P. littoralis extract might be potential candidate agents for the treatment of human colorectal cancer.