시험관아기 프로그램에서 과배란유도 약제의 종류에 따른 황체기 혈청 난포호르몬 및 황체호르몬의 변동에 관한 비교연구

장윤석,신창재,김정구,문신용,이진용,김학순,Chang, Yoon-Seok,Shin, Chang-Jae,Kim, Jung-Gu,Moon, Shin-Yong,Lee, Jin-Yong,Kim, Hak-Soon 대한생식의학회 1989 Clinical and Experimental Reproductive Medicine Vol.16 No.1

Steroid hormone profiles during luteal phase of clomiphene citrate(CC)/human menopausal gonadotropin(hMG)/human chorionic gonadotropin(hCG)-stimulated in vitro fertilization (IVF) cycles and of follicle-stimulating hormone(FSH)/hMG/hCG-stimulated IVF cycles were compared. In seventy three cycles stimulated with CC/hMG/hCG regimen, follicles were aspirated during exploratory laparotomy and yielded 7 pregnancies, and in 83 cycles stimulated with FSH/hMG/hCG regimen, follicles were aspirated by laparoscope and made 13 pregnancies. Serum estradiol($E_2$) and progesterone($P_4$) levels were determined on days 2, 5, 7, and 9 after follicle aspiration. The FSH/hMG/hCG regimen was more effective than the CC/hMG/hCG regimen in folliculogenesis, ie, ovarian stimulation, follicular phase $E_2$ peak levels, oocyte maturation, and the number of retrieved oocytes. There was no significant difference between luteal serum $P_4/E_2$ ratio of the two regimens, suggesting that secretory endometrial build-up ability for implantation may not differ each other. Several significant correlations were observed between follicular phase seum $E_2$ peak levels and luteal phase serum $E_2$ and $P_4$ levels in the FSH/hMG/hCG-stimulated cycles but any correlation was not significant in the CC/hMG/hCG-stimulated cycles, suggesting that somewhat more follicles may eventually fall in atresia even after attaining dominant stage in the CC/hMG/hCG-stimulated cycles than the FSH/hMG/hCG-stimulated cycles.

분산 RAID 기반의 클러스터 시스템을 위한 분할된 결함허용정보 저장 기법

장윤석,Chang, Yun-Seok 한국정보처리학회 2003 정보처리학회논문지 A Vol.10 No.2

This paper presents a new striped checkpointing scheme for serverless cluster computers, where the local disks are attached to the cluster nodes collectively form a distributed RAID with a single I/O space. Striping enables parallel I/O on the distributed disks and staggering avoids network bottleneck in the distributed RAID. We demonstrate how to reduce the checkpointing overhead and increase the availability by striping and staggering dynamically for communication intensive applications. Linpack HPC Benchamark and MPI programs are applied to these checkpointing schemes for performance evaluation on the 16-nodes cluster system. Benchmark results prove the benefits of the striped checkpointing scheme compare to the existing schemes, and these results are useful to design the efficient checkpointing scheme for fast rollback recovery from any single node failure in a cluster system. 본 논문에서는 서버를 사용하지 않고 각 노드에 연결된 지역 디스크들을 이용하여 분산 RAID 저장 장치를 구성하는 분산 환경의 클러스터 컴퓨터를 위한 분할된 결함허용정보 저장 기법을 제안한다. 클러스터 노드들의 결함허용정보를 주기적으로 동시에 분산 RAID에 저장하는 방법은 분산 RAID의 병렬성을 이용할 수 있고, 각 노드의 결함허용정보를 순차적으로 저장하는 기법은 분산 환경에서 네트워크에 병목 현상을 방지할 수 있는 장점을 가지고 있다. 본 연구에서는 분산 RAID를 저장 장치로 사용하는 클러스터 컴퓨터에서 이들 두 가지 기법을 결합함으로써 통신 부하가 큰 응용에서 노드들에 대한 결함허용정보 저장 비용을 줄이고 클러스터의 가용성을 높일 수 있도록 하였다. 제안된 기법의 성능을 검증하기 위하여 본 연구에서는 16노드의 클러스터 시스템에서 MIP와 Linpack HPC 벤치마크 프로그램을 이용한 성능 평가를 수행하였다. 벤치마크 결과는 분할된 결함허용정보 저장 기법이 기존의 기법들에 비하여 분산 RAID를 사용한 클러스터 컴퓨터에서 비교적 우수한 성능을 나타낼 수 있으며, 클러스터의 단일 노드 결함이 발생되었을 경우에 빠른 회복을 수행하는 결함허용정보저장 기법을 설계하는 데에 효과적으로 이용될 수 있다.

관통균열 세관의 파열압력 예측을 위한 탄소성 파괴역학 해석

장윤석,문성인,김영진,황성식,김정수,김윤재,Chang Yoon-Suk,Moon Seong-In,Kim Young-Jin,Hwang Seong-Sik,Kim Joung-Soo,Kim Yun-Jae 대한기계학회 2005 大韓機械學會論文集A Vol.29 No.10

The structural and leakage integrity of steam generator tubes should be sustained all postulated loads with appropriate margin even if a crack is present. During the past three decades, for effective integrity evaluation, several limit load solutions have been used world-widely. However, to predict accurately load carrying capacities of specific components under different conditions, the solutions have to be modified by using lots of experimental data. The purpose of this paper is to propose a new burst pressure estimation scheme based on fracture mechanics analyses for steam generator tube with an axial or circumferential through-wall crack. A series of three dimensional elastic-plastic finite element analyses were carried out and, then, closed-form estimation equations with respect to both J-integral and crack opening displacement were derived through reference stress method. The developed engineering equations were utilized for structural integrity evaluation and the resulting data were compared to the corresponding ones fiom experiments as well as limit load solutions. Thereafter, since the effectiveness was proven by promising results, it is believed that the proposed estimation scheme can be used as an efficient tool for integrity evaluation of cracked steam generator tubes.

입력신호 그룹화 방법에 의한 BIST의 테스트 시간 감소

장윤석,김동욱,Chang, Yoon-Seok,Kim, Dong-Wook 대한전자공학회 2000 電子工學會論文誌-SD (Semiconductor and devices) Vol.37 No.8

The representative area among the ones whose cost increases as the integration ratio increases is the test area. As the relative cost of hardware decreases, the BIST method has been focued on as the future-oriented test method. The biggest drawback of it is the increasing test time to obtain the acceptable fault coverage. This paper proposed a BIST implementation method to reduce the test times. This method uses an input grouping and test point insertion method, in which the definition of test point is different from the previous one. That is, the test points are defined on the basis of the internal nodes which are the reference points of the input grouping and are merging points of the grouped signals. The main algorithms in the proposed method were implemented with C-language, and various circuits were used to apply the proposed method for experiment. The results showed that the test time could be reduced to at most $1/2^{40}$ of the pseudo-random pattern case and the fault coverage were also increased compared with the conventional BIST method. The relative hardware overhead of the proposed method to the circuit under test decreases as th e size of the circuit to be tested increases, and the delay overhead by the BIST utility is negligible compared to that of the original circuit. That means, the proposed method can be applied efficiently to large VLSI circuits. 집적도 증가에 따라 비용이 증가하는 가장 대표적인 분야가 테스트 분야이며, 하드웨어 비용의 상대적인 감소에 따라 BIST 방법이 미래지향적 테스트 방법으로 지목받고 있다. 이 방법이 가지는 가장 큰 단점은 만족할 만한 고장검출률을 얻기 위해 필요한 테스트 시간의 증가이다. 본 논문에서는 BIST의 실현에 있어서 테스트 시간을 감소시키는 방안을 제안하였다. 이 방법은 입력의 그룹화와 테스트 포인트 삽입 방법을 사용하며, 테스트 포인트는 기존에 사용하던 것과는 다름 새로운 정의에 의해 결ㅈ어된다. 제안한 방법의 주요 알고리듬을 C-언어로 구현되었으며, 여러 가지 대상회로를 통해 실험한 결과 의사-무작위 패턴을 사용하는 경우에 비해 최대 $10^7$ 정도의 테스트 시간 감소를 가져올 수 있었으며, 고장검출률 또한 기존의 BIT방법보다 큰 것으로 확인되었다. 제안한 방법의 대상회로에 대한 상대적인 하드웨어 오버헤드는 대상회로가 커질수록 감소하고 지연시간 증가는 대형회로의 지연시간에 비해 미미한 것이어서, 대형회로를 BIST 방법에 의해 테스트할 때 제안한 방법이 매우 효과적일 것으로 사료된다.

다중 분할된 구조를 가지는 클러스터 검사점 저장 기법

장윤석,Chang, Yun-Seok 한국정보처리학회 2006 정보처리학회논문지 A Vol.13 No.7

검사점 저장 기법을 사용하여 주기적으로 클러스터 노드들의 프로세스 수행 정보를 전역 저장 장치에 저장하는 분산 클러스터 시스템에서 결함 허용 성능을 유지하는 데 드는 비용을 줄이고 전체 프로세스의 수행 성능을 증가시키기 위해서는 검사점 정보를 저장할 때에 네트워크로 전달되는 부하를 각 노드에 최대한 적절하게 분산하여 데이터 저장 시간을 줄임으로써 검사점 정보를 저장하는 동안 전체 클러스터 시스템의 프로세스가 지연되는 시간을 줄이도록 하여야 한다. 이를 위하여 분산 RAID 기반의 단일 입출력 공간을 사용하는. 클러스터 시스템에서는 여러가지 검사점 저장 기법을 사용하며, 검사점 정보의 저장 기법에 따라서 저장 성능과 결함 회복 성능이 달라진다. 본 연구에서는 분할된 검사점 저장 기법을 개선하여 검사점 데이터를 분산 RAID 기반의 단일 입출력 공간에 저장할 때에 그룹별로 분할되는 분할 그룹 크기를 검사점 정보가 저장될 때의 네트워크의 트래픽에 따라서 동적으로 결정하여 네트워크를 통한 분산 RAID에 저장함으로써 네트워크 병목현상을 최소화하는 다중 분할된 검사점 저장 구조를 제안하였다. 제안된 구조의 성능을 분석하기 위하여 최대 512개의 가상 노드로 구성된 클러스터 시스템을 대상으로 하여 MPI 와 Linpack HPC 벤치마크를 통한 성능 평가를 수행하였으며, 성능 평가 결과는 검사점 정보의 크기와 클러스터의 크기가 증가할수록 제안된 기법이 검사점 정보의 저장과 결함 회복 능력에 대하여 기존의 검사점 저장 기법에 비하여 우수한 성능을 보인다. The checkpointing schemes should reduce the process delay through managing the checkpoints of each node to fit the network load to enhance the performance of the process running on the cluster system that write the checkpoints into its global stable storage. For this reason, a cluster system with single IO space on a distributed RAID chooses a suitable checkpointng scheme to get the maximum IO performance and the best rollback recovery efficiency. In this paper, we improved the striped checkpointing scheme with dynamic stripe group size by adapting to the network bandwidth variation at the point of checkpointing. To analyze the performance of the multi striped checkpointing scheme, we applied Linpack HPC benchmark with MPI on our own cluster system with maximum 512 virtual nodes. The benchmark results showed that the multistriped checkpointing scheme has better performance than the striped checkpointing scheme on the checkpoint writing efficiency and rollback recovery at heavy system load.

Zigbee USN 기반의 무선 ECG 측정 시스템

장윤석,김보연,Chang, Yun-Seok,Kim, Bo-Yeon 한국정보처리학회 2011 정보처리학회논문지 C : 정보통신,정보보안 Vol.18 No.3

본 연구에서는 ECG 신호를 측정하는 시스템에서 센서들과 기기 사이의 연결을 Zigbee 네트워크를 사용하여 무선화하고, 이를 통하여 이동성과 편리성을 제공하면서도, 병원용 ECG 기기에 준하는 데이터 정밀도를 가지는 U-healthcare용 ECG 시스템을 설계, 구현하였다. 대부분의 의료용 기기에서 이동성에 가장 문제가 되는 것은 센서와 기기를 연결하는 케이블로, 본 연구에서는 이를 줄이거나 없애는 방법으로 Zigbee를 기반으로 데이터를 송수신하는 센서 모듈과 컬렉터 모듈을 설계, 구현하여 근거리에서 동작하는 무선 네트워크를 구성하고, 이를 통하여 각 송신 모듈로부터 전송되는 데이터들을 수신하는 Zigbee-SD 전송 시스템을 설계, 구현하였다. 또한 ECG 신호의 분석과 처리에 스마트폰을 사용하여 데이터 분석과 심박수 표시를 수행하는 앱 응용 프로그램으로 구현함으로써 유비쿼터스 환경에서 이동성과 편리성을 최대한으로 제공할 수 있는 효과적인 U-healthcare 시스템을 구현하였다. Recent expansion of the ubiquitous environment and improvement of the USN give lots of U-healthcare systems. In this paper, we design and implement a wireless ECG measurement system that can send ECG signals among the sensors and collector. It can also give almost the same precision as a hospital ECG system with mobility. The most important fact of the mobile ECG system is the signal data connectivity among the sensors and device such as signal cables or wires. we can eliminate the signal cable through the Zigbee sender and collector via implementing Zigbee-SD communication system that can receive the ECG signal data. We also implement ECG app software on the smart phone that can analyze and show the data results directly. It can give lots of mobility and usability under ubiquitous environment and would be a very efficient wireless ECG system for U-healthcare service.

정상월경주기및 클로미펜을 이용한 배란유도 월경주기에서의 난포성장에 관한 연구

장윤석,이진용,문신용,김정구,임용택,한광수,Chang, Y.S.,Lee, J.Y.,Moon, S.Y.,Kim, J.K.,Lim, Y.T.,Han, K.S. 대한생식의학회 1986 Clinical and Experimental Reproductive Medicine Vol.13 No.1

Follicle monitoring in the normal and clomiphene·stimulated cycles were analyzed in the Seoul IVF and ET (In vitro fertilization and embryo transfer) program. Ovarian follicular diameters were measured by the real·time sector scanner and plasma estradiol levels were assayed by radioimmunoassay methods during periovulatory period. The maximum follicular sizes of the clomiphene-stimulated and normal cycles were 21.1+-3.4mm and 19.2+-0.8mm, respectively. The peak levels of plasma estradiol in the clomiphene-stimulated and normal cycles were 10538+-553.6ng/ml and 298.3+-39.6pg/ml, respectively. Daily growth rate of the follicular diameters of the clomiphene-stimulated and normal cycles were 2.1mm and 1.9mm, respectively. Mean follicular number of the clomiphene-simulated and normal cycles were 2.28+-1.12 and 1.12+-0.21, respectively. There was a good statistical correlation between the mean follicular diameters and the plasma estradiol levels in the normal ovulatory and c1omiphene-stimulated ovulatory menstrual cycles (p<0.05). Our data revealad that the mean follicular diameter and the plasma estradiol level prior to HCG administration in IVF and program should reach at the level of 17.8+-3.0mm and 949.4+-487.1 pg/ml, respectively.

도시 소각로 시설의 고형 쓰레기 연소 후 생성된 바닥재 시료에 대한 다이옥신과 퓨란류의 분석

장윤석,홍종기,김진영,Chang, Yoon-Seok,Hong, JongKi,Kim, Jin-Young 대한화학회 1995 대한화학회지 Vol.39 No.7

다이옥신은 환경에 미량으로 존재하며 직접, 간접적인 경로를 통해 인체로 들어와 심각한 문제를 일으키는, 화학적으로 안정하고 잔류성과 독성이 강한 오염물질이다. 쓰레기 처리를 위한 소각로 시설은 다이옥신에 대한 대기오염의 주원인으로 알려져 있는데 연소시 소각로내에서와 배기가스 제어과정 중 다이옥신이 발생되는 것으로 보고되고 있다. 본 연구에서는 쓰레기 소각로에서 연소 후 생성된 바닥재 시료를 채취하여 다이옥신과 퓨란류를 조사하였다. 시료의 전처리는 EPA방법을 개선하여 불필요한 과정을 생략하면서 높은 회수율을 유지하였고 최종 정량은 고분해능 기체 크로마토그래피/고분해능 질량분석기(HRGC/HRMS)를 이용하여 분석하였다. 바닥재 시료를 분석한 전체 다이옥신의 양은 8.05 ng/g, 퓨란은 4.75 ng/g정도이었으며 2,3,7,8-TCDD는 6.93 pg/g이 검출되었고 염소원자 가 6~7개 치환된 다이옥신과 퓨란이 가장 많이 검출되는 경향을 볼 수 있었다. Polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) are the most concerned toxic organic pollutants to human. Because of their extremely high toxicity and uncertain genotoxic potential, their determination in environmental and biological samples is of great interest. Municipal solid waste incinerator facilities have been reported as the major contributors of dioxins and furans to the environment, and their formation from combustion is a universal phenomenon, everywhere. In this study dioxins and furans were analyzed from the bottom ash produced during combustion in an municipal waste incinerator located in Seoul. The EPA method was modified for sample pretreatment: the soxhlet method was used for extraction and clean-up procedures were performed by using silica and basic alumina, excluding active-carbon. The extract was then analyzed by HRGC/HRMS. A general trend of increase in the amounts of 6∼7 chlorine-substituted dioxins and furans was observed. Total dioxins, furans and 2,3,7,8-TCDD were determined as 8.05 ng/g, 4.75 ng/g, and 6.93 pg/g, respectively.

불임증(不姙症) 환자(患者)의 통계적(統計的) 고찰(考察);서울대학교병원(大學校病院) 불임상담실(不姙相談室) 1872 예(例)의 분석(分析)

장윤석,이진용,문신용,김정구,최승헌,임용택,Chang, Y.S.,Lee, J.Y.,Moon, S.Y.,Kim, J.K.,Choi, S.H.,Lim, Y.T. 대한생식의학회 1985 Clinical and Experimental Reproductive Medicine Vol.12 No.1

This study was presented of the 1,872 cases of infertile couples who visited and examined at the sterility clinic of Department of Obstetrics & Gynecology, Seoul National University Hospital from Sept., 1980 to Dec., 1983. Age, duration of infertility, past medical history, and other general factors were analyzed, and the factors responsible for infertility were classified and discussed. Mode of treatment, outcome of pregnancy, pregnancy rate responsible for each factor were also presented. The results were as follows: 1) The infertility was primary in 1,128, or 60.3% and secondary in 744, or 39.7%. 2) The age between 26 and 30 years of age comprised about one half of the total patients. 3) The duration of infertility between 1 and 4 years comprised about three quarters of the total patients, and the mean duration was 3.8 years. 4) The most common medical history in primary infertility was tuberculous disease, and that in secondary infertility was history of previous laparotomy. 5) About two thirds of antecedent pregnancies were abortion. 6) The major etiologic factor of infertility were male factor in 12.3%, tubal factor in 38.8%, ovulatory failure in 25.4%, uterine factor in 8.8%, cervical factor in 5.2%, peritoneal factor in 9.5%, and no demonstrable cause in 11.3%. 7) The types of male factor were azoospermia in 61.6%, oligospermia in 25.8%, low motility in 11.6%, and other abnormality in 1.0%. 8) The types of ovulatory failure were ovarian failure in 7.4%, hypothalamo-pituitary failure in 8.1 %, hypothalamo-pituitary dysfunction (including Polycystic ovarian syndrome) in 30.2%, and hyperprolactinemia in 22.4%. 9) The types of uterine factor were endometrial tuberculosis in 27.5%, uterine synechia in 33.8%, uterine anomaly in 19.7%, myoma and polyp in 9.1 %, and luteal phase defect in 9.9%. 10) The types of peritoneal factor were pelvic adhesion in 80.9% and endometriosis in 19.6%. 11) Surgeries were done in 408 patients, and they were salpingolysis, lysis of extraadnexal adhesion, salpingostomy, fimbrioplasty, ovarian wedge resection for polycystic ovarian disease, tubo-tubal anastomosis, and tubo-uterine implantation in orders. 12) 243 pregnancies were achieved during the infertility work-up, of which livebirth was 46.5%, ectopic pregnancy was 7.4%, spontaneous abortion was 7.8%, and on-going pregnancy or lost to follow-up was 36.2%. 13) Pregnancy rates in various factors were male factor in 18.7%, ovulatory factor in 31.7%, tubal factor in 24.2%, uterine factor in 34.6%, cervical factor in 19.0%, peritoneal factor in 29.0%, combined factors in 10.5%, and unexplained infertility in 37.1%. Pregnancy rate in whole patients was 25.2%.

원자력 배관재료의 파괴저항곡선 예측

장윤석,석창성,김영진,Chang, Yoon-Suk,Seok, Chang-Sung,Kim, Young-Jin 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.11

In order to perform leak-before-break design of nuclear piping systems and integrity evaluation of reactor vessels, full stress-strain curves and fracture resistance (J-R) curves are required. However it is time-consuming and expensive to obtain J-R curves experimentally. The objective of this paper is to modify two J-R curve prediction methods previously proposed by the authors and to propose an additional J-R curve prediction method for nuclear piping materials. In the first method which is based on the elastic-plastic finite element analysis, a blunting region handling procedure is added to the existing method. In the second method which is based on the empirical equation, a revised general equation is proposed to apply to both carbon steel and stainless steel. Finally, in the third method, both full stress-strain curve and finite element analysis results are used for J-R curve prediction. A good agreement between the predicted results based on the proposed methods and the experimental ones is obtained.