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궤양성 대장염에서 점소 당항원 sTn 과 Tn 의 발현에 관한 연구
장무선(Moo Sun Chang),도재혁(Jae Hyuk Do),김형준(Hyung Jun Kim),유경금(Kyung Kum Yoo),박수정(Soo Jeong Park),문철(Cheol Moon),허철행(Cheol Heang Heo),김재규(Jae Gyu Kim),장세경(Sae Kyung Chang),박실무(Sil Moo Park),김미경(Mi Kyung K 대한내과학회 1997 대한내과학회지 Vol.52 No.1
Objectives: Long standing observation, which may relate either to the causes or the effects of UC, reveals that there is a pronounced alteration of mucin such as quantitative and qualitative abnormalities of mucin glycoprotein. But recently in situ hybridization technique showed no specific difference in the expression of apomucin mRNA in UC. Therefore we investigated whether abnormality of mucin was originated from defect in glycosylation. And we also tried to find differences in the expression of Tn and sTn antigens between Korean and Jewish patients with UC. Methods: We performed the immunohistochemical staining using the monoclonal antibody of mucin carbohydrate antigens Tn and sTn in 19 patients with UC. Results: Tn and sTn antigens were not expressed throughout the crypt and surface epithelium in normal colon but both of mucin carbohydrates antigens were well expressed in mild UC, Tn antigen was seen in the surface epithelium with perinuclear pattern and sTn antigen was shown not only in surface but also in crypt epithelium. In severe UC, Tn antigen was well expressed, but sTn antigen was not expressed. Tn antigen seemed to be ex-pressed more frequently than sTn antigen with severity of inflammation. These results were similar in Korean and Jewish patients with UC. Conclusion: These results suggest that inflammatory bowel disease has some deterioration in the step of glycosylation in the cytoplasm and there was no racial difference in the expression of Tn and sTn antigen in Korean and Jewish patients with UC.
대장선종과 암종에서의 돌연변이 p53과 PCNA의 발현
손승우(Seung U Son),정우식(Woo Sik Jeong),장무선(Moo Sun Chang),한기수(Ki Soo Han),장세경(Sae Kyung Chang),유병철(Byung Chul Yoo),박실무(Sill Moo Park),박언섭(Eon Sub Park) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.4
N/A Mutations in the p53 tumor suppressor gene are frequently observed in colon, lung, breast, stomach and many other neoplasms, suggesting that these mutations are critical events in the maligant transformation. PCNA(proliferating cell nuclear antigen), known as a 36 kD nuclear protein associated with a cell cycle, reported as a useful tool to study cell kinetic information with histologically based tumor classification. We studied to see the correlation between p53 expression and PCNA expression of the colorectal carcinoma and adenoma. We examined the presence of mutant p53 gene, PCNA expression in 47 cases of colorectal carcinoma, adenoma by using immunohistochemical staining. Although it seems that p53 irnmunoreactivity and PCNA expression was not related with cellular differation and lymph node metastasis, colon cancer group with high expression of p53 showed increment of PCNA expression. (Korean J Gastroenterol 1994; 26: 647 654)
Alpha - subunit / TSH Molar Ratio 가 증가되지 않은 갑상선 자극호르몬 분비 뇌하수체 선종 1 예
곽미향(Mi Hyang Kwak),배현철(Hyun Chul Bae),최성남(Seong Nam Choi),이광제(Kwang Je Lee),박수정(Soo Jeong Park),장무선(Moo Sun Chang),신순현(Soon Hyun Shinn) 대한내과학회 1997 대한내과학회지 Vol.53 No.6
Thyrotropin(TSH)-secreting pituitary adenoma is a rare disorder causing hyperthyroidism, which is one of the syndrome of inappropriate secretion of TSH. It is characterized by high serum T₄, T₃ as well as elevated serum TSH. Generally serum free α-subunit concentration is also increased and α- subunit/TSH molar ratio is more than 1. This α- subunit/TSH molar ratio is a clue of diagnosis as well as a useful marker of therapeutic response. We experienced a case of 29-years old man with hyperthyroidism due to TSH-secreting pituitary adenoma. He was underwent 1.5cm sized pituitary tumor removal via transsphenoidal approach in our neurosurgery department. In immunohistochemical stain monotonous tumor cells showed strong positive reaction to antihuman TSH antibody and equivocal reaction to ACTH antibody. After operation, goiter size was progressively decreased and also serum T₄, T₃and TSH were decreased in nearly normal range. However, he showed elevated serum T₄, T₃and TSH after 1 month due to residual tumor. So he received radiation therapy thereafter. In this case the α -subunit and α-subunit/TSH molar ratio were not increased. So we report a case of TSH-secreting pituitary macroadenoma which had low α-subunit/TSH molar ratio with a literature review.