http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 장대영(Dai Young Zang) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
소화성 궤양 출혈에 있어서 Absolute Alcohol 을 이용한 내시경적 경화요법에 대한 연구
김욱(Wook Kim),이문희(Moon Hi Lee),김진봉(Jin Bong Kim),채수희(Soo Hee Chae),장대영(Dai Young Zang),이진(Jin Lee),손주현(Joo Hyun Sohn),김동준(Dong Jun Kim),곽상택(Sang Tack Kwack),주상언(Sang Aun Joo) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
Objectives: Upper gastrointestinal bleeding is the most common complication of peptic ulcer disease which has been known to occur when the luminal offensive factors overcome the mucosal defenses. It has about a 10% mortality rate although it may vary with therapeutic modalities applied. The present study is to evaluate the efficacy of endoscopic sclerosis using absolute alcohol. Methods: For local injection of alcohol, an EVE gastrofiberscope (Fujinon), a flexible needle injector (MN1-k injector), and absolute alcohol were prepared. Endoscopic sclerosis using absolute alcohol was performed in 102 emergency room patients with complaints of hematemesis and/or melena on arrival, and the diagnosis of bleeding peptic ulcer was confirmed through emergency endoscopy. Results: Success at initial attempt. With the initial treatment, the bleeding was brought under control in 96 of 102 patients (94.1%). The results of the study of the patients in whom hemostasis is successfully attained were divided into two groups (I and II) based on endoscopic appearances of the ulcer. 1) Group I (visible vesel): i) 29 of 32 patients (90.6%) with active bleeding ii) 25 of 26 patients (96.2%) with oozing iii) 6 of 6 patients (100%) with no bleeding Overall succes rate at the initial attempt is 93.8% or in 60 of 64 patients. 2) Group II (non-visible vessel): i) 12 of 14 patients (85.7%) with active bleeding ii) 16 of 16 patients (100%) with oozing iii) 8 of 8 patients (100%) with no bleeding Overall success rate at the initial attempt is 94.7% or in 36 of 38 patients. 2. Failure: In 6 patients (4 in Group I and 2 in Group II), initial hemostasis was unsuccessful due to technical difficulties as the ulcers were located in the high posterior wall of the body of the stomach in 2 patients and to massive bleeding in 3 patients. One patient had a continuous oozing of blood after endoscopic hemostasis. Five patients underwent successful emergency operation. One patient with oozing stopped spontaneously. 3. Rebleeding: Four patients rebled 6 to 72 hours after the procedure. Two patients responded to a repeated alcohol injection, and 2 patients undersent successful emergency operation. 4. On follow of 95 patients, ninety-one were found to have ulcers healed 4 to 8 weeks later except for seven patients who underwent emergency operation. Four patients did not return for follow-up endoscopy. Conclusion: It is concluded that endoscopic absolute alcohol injection is proven to be a safe, simple, economical and effective therapeutic modality for upper gastrointestinal bleeding secondary to peptic ulcer disease.
-
김태원(Tae Won Kim),이정신(Jung Shin Lee),최성준(Sung Jun Choi),최종수(Jong Soo Choi),장대영(Dai Young Zang),이제환(Je Hwan Lee),김성배(Sung Jun Choi),김상위(Sang We Kim),서철원(Cheol Won Suh),이규형(Kyoo Hyung Lee),김우건(Woo Kun Ki 대한내과학회 1997 대한내과학회지 Vol.52 No.2
Objectives: The advent of intense combination chemotherapy has transformed aggressive non-Hod-gkins lymphoma from a disease that was once uniformly fatal to one that is now often curable. Remission rates and survival may be improved by using intensive chemotherapy regimens. However, this more aggressive approach is inevitably associated with increased toxicity, and an accurate pretreament prognostic assessment of patients is required to guide the physician in selecting the most appropriate therapeutic regimen. Many studies have reported prognostic factors of non-Hodgkins lymphoma in western countries, but there are few reports on prognostic factors in Koreans and it is suggested that clinical characteristcs of non-Hodgkins lymphoma in Korea differ from those in western countries. The purpose of this study was to illustrate clinical characteristics, prognostic factors and treatment outcome in non-Hodgkins lymphoma in Korea. Methods: Clinical features of 151patients (age over 15years) with non-Hodgkins lymphoma registered at Asan Medical Center from March 1989 to December 1993 were retrospectively reviewed. Prognostic factors and treatment outcome were evaluated among 121previously untreated patients. Multi variate analysis of potential pretreatment prognostic factors was performed using Coxs proportional hazards model. Results: Of the 151patients evaluated, 55% had diffuse large cell type, while low-grades were encountered in less than 1% of the patients. Extranodal involvement was noted in 76% of the patients. Cental nervous system was the commonest primary extranodal site, followed by stomach. Complete remission was achieved in 73 of 121patients (60%). The median follow-up for 121patients was 24months and the actuarial overall survival was 48% at 3years and 44N at 5years with a median overall survival of 33months. At the median followup of 32months, the actuarial 5year disease-free survival rate among 73patient with complete remission was 65% and median remission duration was not reached. Presence of systemic B symptoms and advanced clinical stages were associated with a low complete remission rate. None turned out to be associated with the remission duration. The Coxs proportional hazards model identified age above 60years, presence of systemic B symptoms and elevated LDH level as significant independent poor prognostic factors influencing overall survival. Conclusion: This study reveals a low prevalence rate of the low-grades lymphoma and a higher propensity of diffuse large cell type. These results suggest that clinical characteristics of non-Hodgkins lymphoma in Korea are different from those in the western countries. Our data also show that certain pretreatment clinical factors can help in predicting survival and in planning treatment.
-
이제환,김우건,김상위,이정신,이규형,장대영,최종수,김상희,김성배,서철원,지현숙 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.1
Backgrounds : The expression of the MDR-1(multidrug resistance)encoded P-170 glycoprotein(p-170)and CD34 have been well known to be associated with drug resistance in AML(acute myelogenous leukemia). P-170 and CD34 expression in AML have been reported as unfavorble prognostic parameters separately. Methods : P-170 glycoprotein expression was analyzed in correlation with CD34 expression and clinical response in 15 consecutive patients with de novo acute myelgenous leukemia (AML). They were measured with flow cytometry after direct and indirect immunofluorescence staining simultaneously. Results : 1) The positive rate of P-glycoprotein and CD34 were in two of 15 patients(13%), seven of 15 patients(46%), respectively. 2) One of two P-170 positive patients as compared with 7 of 13 P-170 negative patients achieved a complete remission(CR), which showed no clinical significant difference. 3) There was no significant correlation between P-glycoprotein and CD34 expression(r=0.29, p=0.28). 4) In de novo acute myelogenous leukemia, there was no case which expressed both P-170 and CD34 simultaneously. 5) P-glycoprotein and CD34 were not expressed in acute promyelocytic leukemia group. 6) Cytogenetic abnormalities did not show any significant difference in the rate of P-glycoprotein expression, CD34 expression and complete remission. Conclusion : CD34 and P-glycoprotein in acute myelogenous leukemia were independent parameter in this study. Further investigations are warranted for clinical implication.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
