Dapsone으로 치유된 조직구양 혈관종

장경애,최지호,성경제,문기찬,고재경 ( Kyoung Ae Jang,Jee Ho Choi,Kyung Jeh Sung,Kee Chan Moon,Jai Kyoung Koh ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

We report a case of histiocytoid hemangioma(angiolymphoid hyperplasia with eosinophilia) in a 60 year-old female patient who was effectively treated with dapsone. The therapeutic effect of dapsone may support the hypothesis that immunologically mediated reactive process plays a role in the pathogenesis of histiocytoid hemangioma. (Kor J Dermatol 1997;35(2): 350-353)

피부 유육종증의 임상 및 병리조직학적 연구

장경애(Kyoung Ae Jang),최지호(Jee Ho Choi),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),강숙경(Sook Kyung Kang),서호석(Ho Seok Suh),성경제(Kyung Jeh Sung) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.12

Background:Sarcoidosis is a chronic granulomatous inflammatory disorder involving many organs including the skin with various clinical manifestations. Objective:The purpose of this study was to investigate the clinico-pathological characteristics of sarcoidosis. Methods:A total of 19 patients with cutaneous sarcoidosis were enrolled in this study. The hospital charts and histopathological slides of the patients with sarcoidosis diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. Results:1. Three male and sixteen female patients were included(M:F=1:5.3). Age at diagnosis ranged from 4 to 62 years. The mean age was 46 years in male patients and 44.9 years in female patients. 2. Multiple or several(more than 2) skin lesions were common(78.9%). Extremities were the favored sites. Clinically the lesions were presented as subcutaneous nodules, plaques, nodule, macules or papules, patches, psoriasiform, and pitted scar in decreasing order. Cutaneous lesions arising from the scar were present in 3 cases. Six patients(31.6%) complained of systemic symptoms such as fever or weight loss. 3. The systemic involvement was present in 11 cases(57.9%). Lung, hilar lymph nodes, and mediastinal lymph nodes were the most commonly involved organs. 4. Laboratory examinations revealed elevated erythrocyte sedimentation rate(71.4%) and angiotensin converting enzyme(ACE)(90%). In all the patients with elevated level of serum ACE the involvement of intrathorax was present, however one patient with systemic involvement showed normal level of ACE. Serum calcium level was normal in all the patients and the level of CD4/CD8 revealed variable results(1.3 to 3.9). 5. Histopathological evaluation revealed non-caseating epithelioid cell granulomas (100%) with multinucleated giant cells(52.6%) and asteroid body(31.6%). In 11 cases(57.9%), fibrosis was the prominent finding and in two cases(10.5%) partial interstitial necrosis was noted. Histopathologically subcutaneous pattern was predominant in 8 cases(42.1%). The patients with subcutaneous sarcoidosis did not show any specific clinical or laboratory differences from the other types in our study. (Korean J Dermatol 2000;38(12):1583~1589) Conclusion:Cutaneous sarcoidosis showed varied clinical and histopathological manifestations and ran various clinical courses. In cutaneous sarcoidosis women were more commonly involved than in systemic sarcoidosis and more elderly patients were involved in cutaneous sarcoidosis. Extensive work-up for systemic involvement may be mandatory when sarcoidosis is presented with cutaneous lesions or the level of serum ACE is elevated in cutaneous sarcoidosis. The level of CD4/CD8 may be a insignificant laboratory index in sarcoidosis. Also, subcutaneous sarcoidosis may not be a marker of the systemic involvement.

시계열 네트워크분석을 통한 데이터품질 연구경향 및 산업연관 분석

장경애 ( Kyoung Ae Jang ),이광석 ( Kwang Suk Lee ),김우제 ( Woo Je Kim ) 한국정보처리학회 2016 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.5 No.6

The purpose of this paper is both to analyze research trends and to predict industrial flows using the meta-data from the previous studies on data quality. There have been many attempts to analyze the research trends in various fields till lately. However, analysis of previous studies on data quality has produced poor results because of its vast scope and data. Therefore, in this paper, we used a text mining, social network analysis for time series network analysis to analyze the vast scope and data of data quality collected from a Web of Science index database of papers published in the international data quality-field journals for 10 years. The analysis results are as follows: Decreases in Mathematical & Computational Biology, Chemistry, Health Care Sciences & Services, Biochemistry & Molecular Biology, Biochemistry & Molecular Biology, and Medical Information Science. Increases, on the contrary, in Environmental Sciences, Water Resources, Geology, and Instruments & Instrumentation. In addition, the social network analysis results show that the subjects which have the high centrality are analysis, algorithm, and network, and also, image, model, sensor, and optimization are increasing subjects in the data quality field. Furthermore, the industrial connection analysis result on data quality shows that there is high correlation between technique, industry, health, infrastructure, and customer service. And it predicted that the Environmental Sciences, Biotechnology, and Health Industry will be continuously developed. This paper will be useful for people, not only who are in the data quality industry field, but also the researchers who analyze research patterns and find out the industry connection on data quality.

악성 흑색종의 임상 및 병리조직학적 고찰

장경애(Kyoung Ae Jang),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),김종혁(Chong Hyeok Kim) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.11

Background:Cutaneous malignant melanoma represents a tumor arising within the melanocytic systems of the skin. Once considered an uncommon cancer, melanoma is now rising in incidence at a rate faster than any other cancer. Objective:The purpose of this study was to investigate the clinico-pathological characteristics of malignant melanoma. Methods:A total of 61 patients with malignant melanoma were enrolled in this retrospective study. We classified malignant melanoma as follows; ALMM, acral lentigious malignant melanoma, NMM, nodular malignant melanoma, SSMM, superficial spreading malignant melanoma, MM, mucosal melanoma, LMM, lentigo maligna melanoma. We used the staging system of American Joint Committee on Cancer to evaluate the clinical status in our subjects. The hospital charts and histopathological slides of patients with malignant melanoma diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. Immunohistochemical study was performed for S-100 and HMB-45 in 10 cases and for Ki-67 in 5 cases. Results:1. The male to female ratio was 1.3. The mean age at diagnosis was 52.6 years. ALMM was the most common type(52.5%) in this study. ALMM and NMM developed in elderly persons, while SSMM developed in younger persons. Malignant melanomas arising from pre-existing mole were 10 cases(16.4%). 2. In forty two cases(68.9%), malignant lesions were limited to skin, but 19 cases(31.1%) were disseminated to lymph nodes, skin or internal organ at the initial examination. Sole and heel were the favored sites in ALMM. Lower extremities and back were the favored sites in NMM and SSMM. Four patients were initially presented with metastatic symptoms such as dyspnea, abdominal mass, headache, or axillary mass, and cutaneous malignant melanoma eventually were diagnosed as their origin.3. Histopathologically, 6 cases were categorized into amelanotic type and 1 case was into desmoplastic type.4. More than a half cases developed metastases to other organs. Common metastatic sites were lymph nodes, lung, brain, skin, liver, bone, and bladder in decreasing order of frequency. 5. The five-year survival rate was 100% in stage IA, IB, and IIA but 0% in stage IV. Face, chest and lower extremities showed worse prognosis. Men had worse prognosis than women. NMM revealed the lowest 5-year survival rate(30%). Conclusion:Among the prognostic factors such as locations, clinical types, ages, and gender, the stages at the initial presentation was the most important predictable value in our study. Therefore, the early recognition of malignant melanoma is the key to possible cure.(Korean J Dermatol 2000;38(11):1435~1443)

단발성 선천성 부정형 세포 조직구종

장경애 ( Kyoung Ae Jang ),정의창 ( Eui Chang Chung ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3

Indeterminate cell proliferations are rarely described in dermatology literature. Indeterminate cells are characterized by positivity for S-100 protein and CD-la, but are distinguished from Langerhans cells by the absence of Birbeck granules. We present a case of congenital indeterminate cell histiocytoma in a 6-day-old male infant. A Skin examination revealed a solitary, erythematous, 6*6cm, superficially crusted, dome shaped papule on his forehead. A Histopathologic examination showed a dense cellular infiltrate in the dermis, below the atrophic epidermis. Frequently, the nucleus demonstrated a single cleft or crease like the shape of a kidney. These cells showed positivity for S-100 protein. Birbeck granules were not found on electron microscopic examination. (Korean J Dermatol 1998;36(3): 498-501)

Data Governance 구성요소 개발과 중요도 분석

장경애(Kyoung-Ae Jang),김우제(Woo-Je Kim) 한국경영과학회 2016 韓國經營科學會誌 Vol.41 No.3

Data are important in an organization because they are used in making decisions and obtaining insights. Furthermore, given the increasing importance of data in modern society, data governance should be requested to increase an organization’s competitive power. However, data governance concepts have caused confusion because of the myriad of guidelines proposed by related institutions and researchers. In this study, we re-established the concept of ambiguous data governance and derived the top-level components by analyzing previous research. This study identified the components of data governance and quantitatively analyzed the relation between these components by using DEMATEL and context analysis techniques that are often used to solve complex problems. Three higher components (data compliance management, data quality management, and data organization management) and 13 lower components are derived as data governance components. Furthermore, importance analysis shows that data quality management, data compliance management, and data organization management are the top components of data governance in order of priority. This study can be used as a basis for presenting standards or establishing concepts of data governance.

Data Governance 정량평가 모델 개발방법의 제안

장경애(Kyoung-Ae Jang),김우제(Woo-Je Kim) 한국경영과학회 2017 韓國經營科學會誌 Vol.42 No.1

Managing the quantitative measurement of the data control activities in enterprise wide is important to secure management of data governance. However, research on data governance is limited to concept definitions and components, and data governance research on evaluation models is lacking. In this study, we developed a model of quantitative assessment for data governance including the assessment area, evaluation index and evaluation matrix. We also, proposed a method of developing the model of quantitative assessment for data governance. For this purpose, we used previous studies and expert opinion analysis such as the Delphi technique, KJ method in this paper. This study contributes to literature by developing a quantitative evaluation model for data governance at the early stage of the study. This paper can be used for the base line data in objective evidence of performance in the companies and agencies of operating data governance.

4세 여아에 발생한 유육종증

장경애 ( Kyoung Ae Jang ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ),김훈기 ( Hun Ki Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

We report a case of sarcoidosis in a 4-year-old girl. She showed the involvements of the skin and eye, which are the characteristics of sarcoidosis in very young patients, and also showed an unusual finding of hepatosplenomegaly. Because the diagnosis of childhood sarcoidosis is difficult and serious sequelae can develop from sarcoidal uveitis, an early skin biopsy and regular ophthalmologic assessment are essential. (Korean J Dermatol 1998;36(2): 331-334)

Multiple Painful Subcutaneous Nodules on the Face and Extremities

장경애 ( Kyoung Ae Jang ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ),권영미 ( Young Mi Kwon ),지현숙 ( Hyun Sook Chi ) 대한피부과학회 1998 초록집 Vol.36 No.20

Verocay body-prominent myxoid intravascular fasciitis

장경애 ( Kyoung Ae Jang ),최지호 ( Jee Ho Choi ),고재경 ( Jai Kyoung Koh ),이민우 ( Min Woo Lee ) 대한피부과학회 1999 초록집 Vol.37 No.20