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방사선 조사와 병행 처리한 녹차 Polyphenol의 혈구암세포 사멸 촉진 효과
이홍수,Lee Hong Su 대한방사선사협회 2002 대한방사선사협회지 Vol.28 No.1
The Green tea, one of the most popular and favorite drinks in eastern societies, has been reported to have various therapeutic properties. These includes anti-cancer, anti-oxident, anti-endocrine disrupter effects. Its anti-cancer effect was said to be ac
엉겅퀴에서 분리정제한 silybin의 Human Low Density Lipoprotein 수식에 대한 항산화 효과
류병호,김희숙,이백천,이홍수,Ryu, Beung-Ho,Kim, Hee-Suck,Lee, Baek-Cheon,Lee, Hong-Su 한국생명과학회 1998 생명과학회지 Vol.8 No.4
This study was initiated to antioxidant activity of silybin on oxidation of human low density lipoproteins(LDL). Siltbin was extracted from Silybum marianum by the combination of fractionation and it was futher purified by silica gel column chromatography, and isolated active substances were identified silybin by IR, NMR and GC-MS. siltbin inhibited the ozidation of human low density lipoprotein(LDL) mediated by 5$^{\mu}$m CU $^{2+}$ ion in a dose dependent manner. LDL oxidation by congugated dines formation was completely inhibited by silybin at a concentration of 5$^{\mu}$M. The results provide a possibility that silybin might protect LDL against oxidation in atherosclerotic lessions.
Aspergillus oryzae A-5로부터 Low Density Lipoprotein(LDL)의 산화에 대한 항산화 효과
류병호,김동석,조경자,이홍수,진성현,Ryu, Beung-Ho,Kim, Dong-Suck,Cho, Kyung-Ja,Lee, Hong-Su,Jin, Sung-Hyun 한국생명과학회 1997 생명과학회지 Vol.7 No.4
Antioxidative activity of fraction extracted from cultivation of Aspergillus sp. A-5 against oxidation of human low density lipoprotein(LDL) was investigated. Fractions of Aspergillus sp. A-5 cultivation was sucessively purified with ethyl acetate and silica gel column chromatography. The concentration of fraction 4 inhibited Cu$^{2+}$-induced oxidation of LDL almost completely. Band 3 isolated by the further purification of fraction 4 was higher than that of same concentration of $\alpha$-tocopherol, BHA and BHT. The elcetrophoretic mobility of oxidized LDL by addition of Band 3 was faster than that of native LDL, but slower than that of oxidzed LDL. It is concluded that fraction of Aspergillus cultivation contained antioxidants with the capacity to inhibit oxidative modification of LDL.
류병호,이홍수,김현대 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.2
대두 배아로부터 saponin을 분리·정제하여 유리기 억제효과 및 동물의 암세포에 대한 세포 독성을 조사하였다. 유리기 억제활성에 대한 결과를 보면 대두 배아 saponin을 0.5 및 1.0% 씩 첨가한 그여 식에서 4주 동안 사육한 후 간장을 절취하여 간장 획분의 활성산소 및 항산화 관련 효소에 대하여 평가하였다. 간장의 mitochondria 및 microsome 획분의 hydroxy radical (·OH)의 생성에 미치는 영향에서 급여식에 사포닌을 첨가한 급여군에서 ·OH기의 생성억제 효과를 나타내었다. 간장의 microsome 획분에서도 0.5 및 1.0% 투여군에서 H_2O_2 생성억제 효과가 인정되었다. 또한 간장의 cytosol획분에서 O_2· 의 생성은 대조군에 비하여 현저한 억제 효과를 나타내었다. 대두 배아 사포닌의 세포독성을 P338 (mouse lyoupoid neoplasm) 과 L1210 (mouse leukemia) 세포주를 사용하여 실시한 결과 200 ㎍/mL 농도에서 높은 성장억제효과를 나타내었다. 그리고 처리 농도에 따른 대두 배아 추출물이 P338과 L1210에 대한 성장 효과 실험에서도 200㎍/mL에서 높은 성장 억제 효과가 나타났으며 농도가 높을수록 완전히 억제되는 것을 볼 수 있었다. This study was carried out to investigate functional activities of the free radical scavenging and germ of Glycin max. Merrill for cytotoxicity toward P338 and L1210 cells derived from mouse. Effect of crude saponin were examined to oxygen radicals and their scavenger enzymes in liver fractions of Spragae-Dawley(SD) rats. Male rats were fed basic diets of control and experiment diets of 0.5 ~ 1.0 % crude saponin. there were no significant differences in hydroxy radical (·OH) formation of liver mitochondria and microsomes in 1.0% group, while ·OH formations were significantly decrease in 0.5% and 1.0% saponin compared with control group. Their oxygen radical (O_2) scavenging activities were significantly decrease in liver cytosol of 0.5% and 1.0% saponin group compared with control group. Soybean germ saponin was isolated purified by the method of HPLC to investigate the cytotoxicity of mouse cells by using the MTT assay. SA-I less than 50% cytotoxicity. These results suggest that the saponin may play a effective role in attenuating a oxygen radical formations and increasing a scavenger enzyme activities.
심경원,김지연,서희선,이홍수,이상화,강지현 대한비만학회 2002 The Korean journal of obesity Vol.11 No.2
연구배경 : 국내 비만 여성을 대상으로 비용이 적게 들고 단순하면서도 보다 정확하게 체지방률을 추정할 수 있는 체지방률 추정식을 작성함으로써 쉽게 체지방률과 조절해야하는 지방의 양을 판단할 수 있도록 하고자 한다. 방법 : 이대목동병원 비만클리닉을 처음으로 내원한 19세 이상의 성인 여자 607명 중 체질량지수가 25 kg/㎡ 이상인 500명을 연구대상으로 하여 목, 가슴, 허리, 엉덩이, 대퇴, 하퇴, 발목, 상완, 전완, 손목의 10부위의 둘레와 생체전기저항분석법 (bioelectrical impedance analysis, BIA) 방식의 체성분 분석기를 이용하여 체지방률을 측정하였다. 체지방률 추정식을 구하기 위해 BIA에 의한 체지방률을 종속변수로 하고 , 신체 둘레 계측기 및 신장, 체중, 체질량지수, 연령을 독립변수로 하여 단계별 다중회귀분석 (multiple stepwise regression)을 시행하였다. 결과 : 신장과 체중, 연령, 체질량지수 및 신체 둘레 측정치 중 체지방률을 반영하는 지표는 체질량 지수, 전완둘레, 신장, 엉덩이 둘레, 하퇴둘레였고, 이 다섯가지 지표를 이용한 체지방률 추정식은 66.1%의 예측력과 2.86%의 측정 오차를 나타냈다 (R^2=0.661, SEE=2.86). 결론 : 비만한 성인 여성에서 신장과 체중, 연령 및 신체 둘레 계측치를 이용한 본 연구의 추정식은 체지방률(%)을 적은 오차범위로 비교적 정확하게 반영하였다. Background : This study was conducted to develop a regression equation that accurately estimates body fat percentage using relatively easy and inexpensive method in adult obese Korean women. Method : Data were collected among 500 obese Korean women visiting obesity clinic in Ewha woman's university Mokdong hospital, Seoul, Korea. Height, weight, and circumferences at ten body sites (neck, chest, waist, hip, thigh, calf, ankle, arm, forearm, wrist) were measured s well as total body bioelectrical impedance. Results : The full regression equation estimates body fat percentage included six variables : BMI, forearm circumference, height, hip circumference, thigh circumference. This equation accounted for 66.1% of the variance in body weight measured by bioelectrical impedance, and their standard error of estimate was 2.86%. Conclusion : For the obese Korean women in this study, circumference measurements provided a s relatively good estimation of body fat percentage.
회전원판 반응조를 이용한 Pseudomonas sp. KS-96에 의한 gallic acid로부터 pyrogallol의 전환
안성만,김동석,정영기,임복규,이홍수,류병호 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1
In previous paper Pseudomonas sp. KS-96 isolated from the soil to bioconversion into pyrogallol from gallic acid. Continuous bioconversion of pyrogallol was carried out using rotatory disc contactor immobilized Pseudomonas sp. KS-96. Enzyme activity of gallate decarboxylase released from Pseudomonas sp. KS-96 were shown at the highest activity on 24h incubation. Culture media containing gallic acid supplied on the flow rate of 20㎖/h until thickness of cells wall reached steady state. Bioconversion rate of pyrogallol from gallic acid showed at highest level ranging from 18hr to 36h according to time courses. Continuous bioconversion of pyrogallol using rotating disc contactor was about 81% and 80% between 6 and 8 days at the feeding rate of 30㎖ per hour in the medium containing 15g/ℓ gallic acid.