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고콜레스테롤혈증 치료에서 심바스타틴 10mg 과 20mg 사용시의 효능 및 안전성 비교 연구
이재건(Jae Gun Lee),김화민(Hwa Min Kim),이현희(Hyun Hee Lee),최혜진(Hae Jin Choi),박창하(Chang Ha Park),서명덕(Myung Deok Seo),정재천(Jae Cheon Jeong),조한균(Han Kyun Cho),최성식(Sung Sik Choi),이지현(Ji Hyun Lee),김석연(Seok Yeon Ki 대한내과학회 2002 대한내과학회지 Vol.63 No.1
Background: Elevated serum cholesterol level is a major risk factor for cardiovascular morbidity and mortality. Simvastatin is effective for treating hypercholesterolemia. The aim of the study was to evaluate efficacy and safety of 6-month therapy with simvastatin with relatively low dose, 10 mg and 20 mg/day. Methods: One hundred six patients with hyperlipidemia (triglycerides<400 mg/dL and low- density lipoprotein (LDL) cholesterol>130 mg/dL) were randomized to receive either simvastatin 10 mg/day (n=43) or 20 mg/day (n=63). Efficacy was determined by measuring changes from baseline in lipid parameters including LDL cholesterol, total cholesterol, triglycerides and high-density lipoprotein (HDL) cholesterol. Results: Of the one hundred six patients randomized to treatment, forty patients were men and sixty-six patients were women. Fifty-five percent of patients had hypertension, nine percent coronary artery disease and thirteen percent type 2 diabetes mellitus. Mean baseline lipid concentrations were 258 (total cholesterol), 201 (triglycerides), 50 (HDL) and 167 mg/dL (LDL). Both 10 mg and 20 mg of simvastatin produced statistically significant improvements in all measured serum lipid parameters (p<0.001). Compared with 10 mg of simvastatin, 20 mg of simvastatin produced significantly greater (p<0.001) reductions from baseline LDL cholesterol (34.9 mg/dL vs 20.8 mg/dL). But 10 mg of simvastatin was more effective than 20 mg of simvastatin at reducing triglycerides level (42.7 mg/dL vs 22.3 mg/dL). There was no significant difference in both doses at improving total cholesterol and HDL cholesterol level. Percentage of patients at goal LDL as recommended by NCEP guideline (ATP III) were 81% and 80% for patients in low risk but 35% and 50% for patients in coronary heart disease and its risk equivalents, taking 10 mg and 20 mg/day respectively. Both doses were well tolerated. Only 3 patients (4.8%) in the 20 mg group and one patient (2.3%) in the 10 mg group experienced mild adverse events. Most patients contacted by telephone wanted to take 10 mg of simvastatin. Conclusion: In patients with hypercholesterolemia in Korea, both doses (10 mg, 20 mg) of simvastatin were effective in improving serum lipid parameters and well-tolerated. We recommend, considering patients' preference, that 10 mg of simvastatin be intial dosage and in patients with coronary heart disease, higher doses than 20 mg should be prescribed to allow most patients to reach their NCEP target levels.(Korean J Med 63:46-53, 2002)
이해성(Hae-Sung Lee),이재건(Jae-Gun Lee ),김나현(Na-Hyun Kim),이루미(Lu-Mi Lee),이순흠(Sunheum Lee) 한국정보기술학회 2018 Proceedings of KIIT Conference Vol.2018 No.6
병원의 인력 부족은 병원 근로자의 건강 악화, 환자의 의료 서비스 질적 저하 등의 문제가 발생할 수 있다. 본 논문에서 제시하는 병실 환경 관리 시스템은 자이로 센서와 가속도계가 합쳐진 모듈인 가속도 센서와 와이파이 모듈을 사용하여 노약자들의 낙상을 감지하여 더 큰 사고를 예방하는 것을 목표로 한다. 가만히 있을 경우를 기준으로 걷기, 눕기, 낙상을 판단한 후 낙상일 경우 의료진들이 알 수 있도록 서버에 전송하는 시스템을 제안한다. Lack of personnel in hospitals can cause problems such as deterioration of health of hospital workers and deterioration of quality of medical service of patients. The hospital room management system proposed in this paper aims to prevent accidents by detecting fall of elderly people by using accelerometer and WiFi module which are gyro sensor and accelerometer combined module. In case of a fall, the system is transmitted to the server so that the medical staff can know if it is fallen after judging walking, lying down, or falling.
한재건(Jae Gun Han),하지혜(Ji Hye Ha),최영범(Yeong Beom Choi),고정림(Jeong Lim Go),강도형(Do Hyung Kang),이현용(Hyeon Yong Lee) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.4
본 연구는 제주도의 녹조현상의 원인인 구멍갈파래의 활용을 위해 고압추출 공정을 통한 추출물의 면역활성 확인 하였다. 150MPa, 80℃ 조건에서 Superoxide Radical 소거효과에서는 90% 로 활성도가 제일 높았으며, 면역세포 생육도면에서도 B&T cell, 각각 14.2×10sup{4} cells/mL 14.5×10sup{4} cells/mL 나타나 제일 높았다. 반면, NK cell과 NO 면역능 실험에서는 100MPa, 30℃ 조건에서 각각 11.8×10sup{2} cells/mL, 30.0 μM을 보여 주었다. 결과를 통해 구멍갈파래는 면역활성을 가지며 고압 공정을 통한 추출물의 활성이 일반추출에 비해 높은 것을 알 수 있다. 따라서 해조류 및 다른 유용 자원에서도 고압 공정이 기존의 추출방법보다 높은 활성을 나타낼 것으로 판단되며 기능성 식품이나 기능성 소재로서 사용가능성이 있는 것으로 사료된다. The purpose of this study was to investigate the immunomodulatory effect of Ulva pertusa kjellman extract after undergoing a low temperature and high-pressure extraction process. First, the extracts obtained under the extraction conditions of 150 MPa and 80℃ showed a relatively high antioxidant activity, with 90% super oxide radical activity compared to the extracts from conventional extraction process with water at 100℃. This extract also improved the growth of both human immune B and T cells up to 14.5×10sub{4} cells/mL and 14.2×10sub{4} cells/mL compared to 9.1×10sub{4} cells/mL in adding the extracts from conventional processes. It was found that the extracts obtained at 100 MPa and 60℃ showed better activities in NK cell growth and NO production from macrophage as 11.8×10sub{2} cells/mL and 30.0 μM. Overall, the extracts from high pressure and low temperature extraction process had relatively higher immune activation activity, possibly because the low temperature and high pressure extraction process may have higher yields of active compounds and have less damage to useful ingredients from relatively weak marine natural resources, such as Ulva pertusa kjellmann than that from the conventional extraction system.
고압액화공정을 이용한 구멍갈파래의 발효용 알코올 당화수율 증진
한재건(Jae Gun Han),오성호(Sung Ho Oh),최운용(Woon Yong Choi),권정웅(Kwon Jung Woong),서현범(Hyeon Beom Seo),정경환(Kyung Hwan Jeong),강도형(Do Hyung Kang),이현용(Hyeon Yong Lee) 한국생물공학회 2010 KSBB Journal Vol.25 No.4
Green alga, Ulva pertusa kjelmann has been known to be one of the largest pollutants in Korea. Therefore, the efficient pretreatment processes have been required to improve the yields of fermentable sugar. The optimal pretreatment conditions were determined to be 195℃ for 15 min. The sugar yield of glucose and xylose were estimated as 20.5%, and 5.0% respectively, based on theoretical yields. However solid residues were estimated enzymatic digestibility of 90-95% with cellulase loading of 15 FPU/g glucan. This process was proved to generate the low concentration of Hydroxy-Methyl-Furfural (51 ppm), which resulted in ethanol production with 95% of the maximum conversion yield from glucose in the culture of Saccharomyces cerevisiae (ATCC, 24858). This study showed that Ulva pertusa kjellmann can be used as a bioetahnol resource using the high temperature liquefaction process.
유채대의 이단 고온 처리에 의한 알콜 발효용 당화물 생산
한재건(Jae-Gun Han),오성호(Sung-Ho Oh),정명훈(Myoung-Hoon Jeong),김승섭(Seung-Seop Kim),서현범(Hyeon-Beom Seo),정경환(Kyung-Hwan Jeong),장영석(Young-Seok Jang),김일철(Il-Cheol Kim),이현용(Hyeon-Yong Lee) 한국생물공학회 2009 KSBB Journal Vol.24 No.5
우리 연구팀은, 농산부산물인 유채대의 알콜 발효용 당 화물 생산 가능성을 연구하였다. 이를 위해 농산부산물인 유채대를 연속적으로 5 mL/min의 속도로 산을 이용하지 않고 증류수만을 이용해 이단 고온 처리 (200℃ and 15 Mpa, 375℃ and 23 Mpa)하였다. 본 전처리 공정을 통한 가수수분해물의 당화물 생성은 최종적으로 자일로스와 글루코스의 경우 25.6 g/L, 5.5 g/L가 생성되었다. 이는 유채대에 존재하는 글루코스와 자일로스의 초기 양 대비 각각 18%와 59%의 전환 수율을 나타낸다. 또한 이 공정은 타 공정들에 비하여 대표발효 저해 산물인 HMF의 생성량이 0.2 ppm으로 극히 낮은 수치를 보였으며, 가수분해물의 에탄올 생산시, 글루코스의 발효를 통한 에탄올 생성 전환수율이 90% 이상으로 높은 생성율을 보였다. 따라서 본 공정을 통해 다른 농산부산물이나 해조류 전체에 응용된다면, 고 수율의 에탄올 생산용 당화물을 생산할 것으로 예상한다. Two-step pretreatment process was investigated to efficiently hydrolyzed rape stems for obtaining fermentable sugars. The process was consisted of two consecutive steps as 200℃ and 15 MPa and 374℃ and 24 MPa with the flow rate of 5 mL/min. Under this condition, 5.5 (g/L) of glucose and 25.6 (g/L) of xylose were obtained from rape stems, showing 18% of glucose yield based on 25% cellulose in the rape stems. It was also found that this process could generate less amounts of toxic residues, such as HMF (Hydroxy- Methyl-Furfural) and other fulfural components during hydrolysis process. It could reaction maintain relatively high ethanol production yield as 90% of theoretical conversion yield from glucose. Therefore, this pretreatment process could be applied to hydrolyze other cellulosic and marine resources such as woods, stem and algae for bioethanol production.