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李王圭,崔閏壽,姜會洋 최신의학사 1972 最新醫學 Vol.15 No.2
In the previous report, the composition ratio of Cu( I )-sulfa drug's complex-was reported. In this paper the composition ratio of Ag( I ), Hg( I )- sulfa drugs complex by the i athod of v-olumetric titration at optimal pH(7- 8). It has been certified that the ratio of Ag( I )- sulfa drug is 1:1 and Hg (I )-sulfa drug is 1:2 from the result of this experiment.
박층크로마토그라피 및 농도 측정법에 의한 Ampicillin Trihydrate 중의 N,N-Dimethylaniline의 검색
이왕규,김박광,심창구 대한약학회 1978 약학회지 Vol.22 No.4
A simple and convenient method of detecting N, N-dimethy laniline (D.M.A.) residues in ampicillin trihydrate (A.T.) was established. D.M.A. was extracted by chloroform from the chloroform presaturated N/10-ammonia water solution of A.T. and chromatographed on silica gel G thin layer. Blue spot appeared in 15minutes after spray of 2, 6-dichloroquinonechlorimide solution was compared with the blue spot of reference concomitantly processed. The developing solvent was prepared by mixing equal volume of cyclohexane and chloroform. To quantitate the amount of D.M.A. in A.T., T.L.C. was performed with the Eastmann Chromatogram sheet, then color density was measured by Cosmo Superclick densitometer. The developing solvent at this time was cyclohexane-chlorofonn (3+7) mixture. The peak areas obtained with the amount of D.M.A ranging from 0.05 to 2.0 .mu.g were linear to color density. Better sensitive results would be available with the densitometer equipped with monochromator.
이왕규,유경수 대한약학회 1980 약학회지 Vol.24 No.3
Color transition mechanism of shikonin as an acid-alkali indicator was studied. It was confirmed that the presence of phenolic hydroxy radical was essential for the color change of shikonin. But in accordance with shikonin sodium salt (blue color), which was presumed to make chelation as six membered rings. Shikonin in alkaline solution, by dissociated phenolic protons of naphthoquinone nucleous, converted to the corresponding anion and instead of disappearance tautomerization, electron delocalization occurred and an additional pair of nonbonding electrons in the anion was available for interaction with .phi. electron system of the ring with further extension of the conjugation. It was responsible for its blue color(corresponding color: orange) with needs less energy difference (${\phi}{\rarw}{\phi}^{*}$) because of conjugation extension. Shikonin sodium salt seems to have similar nuclear structure as shikonin anion.
Sulfa제-Cu착화합물의 형성에 관하여 II Spectrophotometry 에 의한 Copper Sulfa-Drug Complex 의 화학조성결정
이왕규 대한약학회 1964 약학회지 Vol.8 No.4
In the previous study, the composition ratios of the Cu-sulfa drugs complexes determined by gravimetric and solvent extraction method reported. In this paper, the continuous variations method has been used to know whether the complexes are simple complexes or chelates, and to recertify the composition ratios of the complexes at pH 7-8. It has been certified that the ratio of $Cu^{+2}$ ion to sulfa drugs in 1:2 from the result of this experiment.
Gas-liquid Chromatography에 의한 Ethambutol의 정량
이왕규,강길종,박만기 대한약학회 1975 약학회지 Vol.19 No.4
The quantitative analysis of ethambutol.2HCl as well as commercial ehambutol preparations was undertaken by gas-liquid chromatography by finding optimum conditions, such as the use of internal standard, stability of an ethambutol-2HCl-caffeine standard solution, and the effect of column temperature, N, O-bis-(trimethylsily) acetamide [B.S.A.] concentrations and other substances present in the preparations. Under the chromatiographic conditions, an ethambutol-2HCl. caffeine standard, 9 min, 30sec. The relative molar response of ethambutol.2HCl and caffeine studied was 2.08. Ethambutol.2HCl could be quantitated up to 1$\times$10$^{-8}$ moles. the possible decomposition of B.S.A. due to the moisture when tested and the incoplete reaction for silylation could be minimized.
이왕규,김박광,유병기 대한약학회 1985 약학회지 Vol.29 No.4
Rifampicin reacts with cupric ion to produce rifampicin-Cu(II) chelate (2:1) at pH 6.5, which can be extracted with methylisobutylketone (MIBK). Therefore, rifampicin can be quantitatively, determined by measuring the quantity of Cu(II) in the organic phase by atomic absorption spectrophotometry. Because higher absorbance ratio was obtained in pH 6.0~7.0, buffer solution at pH 6.5 was used in this measurement. Linear relationship was found between absorbance and concentration in the range of 1.0~4.0${\times}10^{-4}M$. This method might be applicable to the determination of rifampicin in the preparations.
Phosphomolybdic Acid 에의한 의약품의 비색정량에 관한 연구(II). Amoxicillin 의 정량
이왕규,유경수,심창구 대한약학회 1977 약학회지 Vol.21 No.1
Amoxicillin formed blue color when heated with phophomolybdic acid in adequate condition, and the color showed maximal absorbance at 760nm. Effect of pH, concentration of phosphomolybdic acid and reating time were studied. And a new colorimetric method of determination of amoxicillin was developed.
고속 액체 크로마토그라피에 의한 cis- 및 trans-Neopynamin과 Fenitrothion의 분리 정량에 관한 연구
이왕규,정해수 대한약학회 1980 약학회지 Vol.24 No.2
A new application of high pressure liquid chromatography for the determination of fenitrothion and cis- and trans-neopynamin in insecticidal preparations was investigated. Optimum conditions for a good separation and determination were determined; solvent system: dichloromethane + n-hexane = 17 + 83; Bow rate: 0.5ml/min; column: u-porasil ($4mm{\times}3Ocm$); absorbance wavelength: 254nm; 0.05 AUFS and sample size: 30 ul. Recovery of fenicrothion, cis- and trans-neopynamin from mixed artificial preparations was 99.6%, 99.7% and 99.8% respectively. Also reproducibility tests showed that the coefficient of variation was 0.89% for fenitrothion, 0.74% cis-neopynamin and 1.1% for trans-neopynamin. There was no interference with insecticidal preparation containing DDVP, allethrin, S-421 and kerosene. HPLC method was rapid, accurate and it gave better reproducibility and higher sensitivity than any other analytical method. It was considered that HPLC could be greatly applied to the analysis of fenitrothion and neopynamin in insecticidal preparations.
HPLC에 의한 Gypsogenin-2,4-DNPH의 정량
이왕규,유병기,김박광 대한약학회 1987 약학회지 Vol.31 No.2
Gypsogenin was derivatized with 2, 4-dinitrophenylhyclrazine prior to analysis with HPLC. Reversed-phase column (Du pont ODS) was used and the mobile phase was acetonitrile and water (60:40). The effluent was detected at 550nm using an U.V. detector and the retention time was approximately 9.2min. The concentration was quantitated by measuring the area and the detection limit was 0.2$\mu\textrm{g}$.
혼합용매중에서의 산-고기 지시약에 관한 연구(I) : 수-유기용매 혼합용매중 Ampicillin, Amoxicillin 및 Cephalexin의 정량
이왕규(Wang Kyu Lee),심창구(Chang Koo Sim) 대한약학회 1976 약학회지 Vol.20 No.1
The pH titration curves of ampicillin, amoxicillin and cephalexin in aqueous acetone, ethanol and N,N'-dimethylformamide by use of 0.02 N-KOH solution showed that 80% acetone was the most effective solvent for alkali titration of them. The pH jumps of samples in 80% acetone were sharp enough to determine the contents of them by use of potentiometric titration. The pKa value of brom thymol blue in 80% acetone (9.4) was coincided with each equivalent point of ampicillin, amoxicillin and cephalexin, but those of phenolphthalein, thymolphthalein, thymol blue and brom cresol purple were not. The color change of brom thymol blue at equivalent points was very clear except the case of amoxicillin that the determination of samples in 80% acetone with 0.02 N-KOH solution by the aid of brom thymol blue could be available.