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다운증후군의 산전진단을 위한 다양한 선별검사의 기여율 비교 - 산전 및 신생아때 진단된 96 례 분석 -
한정열(J . Y . Han),김문영(Y. M . Kim),조준형(J . H . Cho),안현경(H . K . Ahn),류현미(H . M . Ryu),김진미(J . M . Kim),김영미(Y . M . Kim),박소연(S . Y . Park),한혜경(H . K . Han),이영호(Y . H . Lee),양재혁(J . H . Yang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
연구의 목적은 다운증후군을 산전진단하기 위한 다양한 산전선별검사 (나이; 35세 이상, 임산부 혈청 marker를 이용한 triple test, 초음파; 비정상 소견, 후경부 투명대 (nuchal translucency), 후경부두께 (nuchal fold thickness))의 기여율를 비교하기 위한 것이다. 1990년 1월부터 1999년 9월까지 본원에서 산전 및 산후에 진단된 례는 총 96례 이었다. 산전 및 신생아기에 진단된 다운증후군의 빈도는 각각 68례 (71 %), 28례 (29 %)였다. 다운증후군 태아를 임신했던 임산부의 평균연령은 33±5.7세이다. 다운증후군의 1,000분만당 연도별 빈도율은 1990년부터 1999년까지 각각 0.4, 1.3, 0.7, 0.7, 1.6, 0.7, 1.2, 2.2, 2.0, 그리고 2.3 (Y=0.28±0.18 year, P=0.01)이었다. 산전진단된 다운증후군의 비율 (%)은 지난 10년간 각각 0 (0/2), 43 (3/7), 50 (2/4), 25 (1/4), 56 (5/9), 100 (5/5), 71 (5/7), 78 (14/18), 78 (14/18), 그리고 89 (17/19) (Y=12.9±8.9 year, P=0.000) 이었다. 다운증후군을 산전진단하기 위한 다양한 산전선별 검사에 따른 기여율은 35세이상의 연령에 의하면 30.2±5.6 %, triple test의 경우 18.2±3.4 %, 초음파에 의한 경우 51.7±6.3 % 이며, 초음파에 의한 산전 선별 검사가 통계적으로 유의하게 연령이나 triple test에 의한 경우 보다 다운증후군의 산전진단에 기여율이 높았다. (P=0.008) 결론적으로 본 연구에 의하면 지난 10년 동안 다운증후군을 산전 진단하기 위한 여러 선별 검사방법의 적용은 효율적이었으며, 특히 초음파에서 다양한 소견을 이용한 다운증후군의 산전선별검사는 연령이나 triple test 보다는 더욱더 의미가 있다고 추론된다. Objective : The purpose of this study was comparison of the contribution rate for prenatal diagnosis of Down syndrome using various screening methods (Age: greater than or equal to 35 years old, Serum markers: Triple test, Ultrasonography: abnormal sonographic findings, nuchal translucency, nuchal fold thickness).Methods : Total 96 cases of Down syndrome, prenatally or postnatally diagnosed between Jan. 1990 and Sept. 1999, made up the study population. We got the contribution rate of various prenatal screening methods of down syndrome, and obtained the efficiency of various screening program applied for last 10 years. Results : The frequencies of Down syndrome confirmed in prenatal and postnatal were 68 (71%) and 28 (29%) in respectively. The mean age of mother of Down syndrome fetus was 33.0±5.7 years old. The frequency rate of Down syndrome was 0.4, 1.3, 0.7, 0.7, 1.6, 0.7, 1.2, 2.2, 2.0 and 2.3 a 1,000 deliveries from 1990 to 1999 (Y= 0.28+0.18 year, P=0.01). The percentage of Down syndrome diagnosed prenatally was 0 (0/2), 43 (3/7), 50 (2/4), 25 (1/4), 56 (5/9), 100 (5/5), 71 (5/7), 78 (14/18), 78 (14/18) and 89 (17/19) from 1990 to 1999 (Y= 12.9+8.9 year, P=0.000). The contribution rate of prenatal diagnosis for Down syndrome was 30.2±5.6% by age, 18.2±3.4% by triple test and 51.7±6.3% by ultrasonography, and was significantly difference among each screen methods (P=0.008). Conclusions : This study shows that our prenatal screening program is highly effective to detect Down syndrome and especially ultrasonographic findings (abnormal sono findings, Nuchal translucency, Nuchal fold thickness) may be more important than that of age or Triple test to detect the Down syndrome prenatally.
김성윤(SㆍYㆍKim),김유택(YㆍTㆍKim),남청도(CㆍDㆍNam),이영호(YㆍHㆍLee),강호근(HㆍKㆍKang),김성동(SㆍDㆍKim) 한국마린엔지니어링학회 2005 한국마린엔지니어링학회 학술대회 논문집 Vol.2005 No.-
The effect of break down of centrifugal pump due to entrained air has not been clarified yet. Thus, air-water two-phase flow experimental apparatus was installed to clarify the effect of break down. The performance results of a single-phase flow satisfied reappearance. Also, the heads coincided well impeller types.
이영호,최장운,도덕희,Lee, Y.H.,Choi, J.W.,Doh, D.H. 대한설비공학회 1995 설비공학 논문집 Vol.7 No.4
The present numerical study is aimed to investigate time-dependent characteristics of a two-dimensional lid-driven square cavity flow of three high Reynolds numbers, $7.5{\times}10^3$, $10^4$ and $3{\times}10^4$. A conservative convection term on irregular grids was adopted by renewing the MAC type difference schemes on regular grids. Relaxation of velocity and pressure is implemented by SOLA algorithm. In case of $Re=7.5{\times}10^3$, flow behavior converges to steady state after a transient period. But for $Re=10^4$, periodic unsteady sinusoidal fluctuation of local velocity and kinetic energy is found and continuous movements of small eddies in the secondary flow regions are also discovered. Random generation of eddies and their active migrating behavior are detected for $Re=3{\times}10^4$, resulting in complete unsteady and non-linear flow characteristics. And, an organized structure similar to a Moffat vortex is also observed from the time-mean flow patterns. Furthermore, a typoon-like vortex(TLV) appears intemittently and rotates along the separation regions and boundary layers.
이영호(Y.H.Lee),김용환(Y.H.Kim),이광수(G.S.Lee),이현우(H.W.Lee) 전력전자학회 1998 전력전자학술대회 논문집 Vol.- No.-
The development of the high-frequency induction-heating for 2700㎾ power range intend to make localization at forging and rolling mill part by technical innovation And, the development makes to increase our's competitive power at technique, quality and cost. This paper describes the heart of high-frequency induction-heating technique, switching technique, a few problem in common using as an unsatisfied technique, load adjustment technique, system control, diagnostic system, and auto-interface etc.<br/> <br/>
이영호 ( Y . H . Lee ) 한국열처리공학회 1988 熱處理工學會誌 Vol.1 No.1
The hardenability of alloyed ductile cast irons was studied for 54 different alloy compositions obtained from eight commercial and laboratory foundries. The alloying elements investigated for their effects on hardenability were Si(2.0 to 3.0%), Mn(0.0 to 0.8%), Mo(0.0 to 0.6%), Cu(0.0 to 1.5%), and Ni(0.0 to 1.5%). Two hardenability criteria, a first-pearlite hardenability criterion and a half-hard hardenability criterion, were used to determine hardenability of ductile irons. Prediction models for each hardenability criterion were developed by multiple regression analysis and were well agreed with previous experimental results. Molybdenum was the most potent hardenability promoting element followed by manganese, copper and nickel ; silicon had little effect on hardenability and reduced the haedenability as silicon content increased. When alloying elements were presented in combination, strong synergistic effects on the hardenability were observed especially between molybdenum, copper and nickel. The hardenability of ductile iron was strongly influenced by austenitizing temperature. Increasing austenitizing temperature up to 955℃, hardenablilty increased gradually but decreasing rate and then decreased as temperature increased above 995℃. Unless reducing segregation by very long-time annealing treatment, the hardenability of ductile iron was not significantly influenced by segregation of alloying elements.