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- 저자 : 이서지(Suzie Lee) (검색결과 2 건)
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주의력결핍 과잉행동장애 환아들의 인지 행동적 특성과 정량 뇌파와의 관계 : 후향적 단면 연구
오수환(Soohwan Oh),정유숙(Yoo Sook Joung),윤희준(Hee Joon Yoon),이동익(Dong Ik Lee),김병욱(Byung Wook Kim),박정아(Jung Ah Park),이서지(Suzie Lee),이빛나(Bitna Lee) 대한신경정신의학회 2018 신경정신의학 Vol.57 No.3
Objective This study examined the association between the wave form in quantitative electroencephalography (QEEG) and the cognitive and behavioral characteristics measured by the Korean version of Wechsler Intelligence Scale for Children 4th edition (K-WISC-IV), Korean version of the attention deficit/hyperactivity disorder Rating Scale (K-ARS), and Korean version of Child Behavior Checklist (K-CBCL) in children diagnosed with ADHD. Method A retrospective cross-sectional study was performed on children aged 8 to 13 years, who were diagnosed with ADHD at Samsung Medical Center from November 2011 to March 2017. A total of 57 ADHD children were selected by a medical chart review. Their QEEG findings and psychological test results, including K-WISC-IV, K-CBCL, and K-ARS (n=42), were collected. The QEEG was analyzed by the ranges of Hz: delta (1 - 4 Hz), theta (4 - 8 Hz), alpha (8 - 12 Hz), and beta (12 - 25 Hz) and transformed to the z-scored relative power. The collected data were analyzed using Pearson and Partial correlation analysis. Results The Letter-Number Sequencing scores of K-WISC was positively correlated with fronto- central alpha. The hyperactivity/impulsivity scores of K-ARS were positively correlated with the theta/beta ratio. Among the items of K-CBCL, social immaturity was positively correlated with delta and theta, and negatively correlated with alpha. Social competence was negatively correlated delta and theta, and positively correlated with alpha. Conclusion These results suggest that the resting state QEEG results of children with ADHD may reflect their cognitive and behavioral characteristics, especially in working memory/executive function, hyperactivity/impulsivity, and sociality.
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알쯔하이머병 환자 림프구의 세포생존율, 세포증식률 변화
이서지,권영아,김혜란,정성호,안상미,김도관 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4
Objectives : There are evidences of apoptotic neuronal cell death in Alzheimer's disease (AD). Recent studies suggested AD pathogenesis in the central nervous system as well as in peripheral lymphocytes. The object of this study is to compare the cell viability and the proliferation activity in AD patients with healthy normal control by using peripheral lymphocytes. Methods : We analyzed the cell viability and the proliferation activity of phytohemagglutinin (PHA) -activated lymphocytes from 73 AD patients and 31 normal contols. The cell viability and the proliferation activity were measured at baseline (TO), 24 hours (T24), 48 hours (T48), 72 hours (T72), 96 hours (T96), by the tryphan blue method and the BrdU proliferation activity method, respectively. Results : The cell viability of PHA-activated peripheral lymphocytes in AD patients was significantly decreased at T72, T96 compared with healthy controls (F=8.034, p<0.001). In AD patients, the decline of proliferation activity appeared in earlier than healthy normal controls. Conclusion : This study suggests that there is a decreased cell viability and the proliferation activity of peripheral lymphocytes in AD patients. These finding may be related with the increased apoptosis in Alzheimer's disease.
KCI
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