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이상관,성창원,박효선,Lee, Sang Kwan,Seong, Chang Won,Park, Hyo Seon 한국강구조학회 2000 韓國鋼構造學會 論文集 Vol.12 No.6
알고리즘의 용이성과 전역적 최적해로의 수렴가능성 등의 이점을 가진 SA알고리즘은 구조최적화문제에 활발하게 적용되고 있으나 냉각스케줄의 설정, 모호한 종료기준, 과도한 반복해석 등의 문제점을 가지고 있다. 그러므로 본 논문에서는 기존 SA알고리즘의 단점을 보완한 MSA 알고리즘을 개발하고자한다. MSA 알고리즘은 수렴에 요구되는 반복수를 감소시키고 국부최소점이 많은 동적최적화문제의 초기설계 선택의 자율성을 확보하기 위하여 SQ 및 SA의 2단계로 구성하여 개발하였다. 또한 기존 연구에서 제안된 냉각 스케줄에 의한 수렴성 등을 비교분석하여 구조최적화에 적합한 냉각스케줄을 제안하여 그 성능을 평면가새골조 구조물의 최적내진설계에 적용하여 분석하였다. With the positive features of simulated annealing algorithms such as simplicity of the algorithm and the possibility of finding global optimum solution, SA algorithm has been widely applied to structural optimization problems. However, the algorithms are far from practical applications in structural design or optimization of building structures due to requirement of a large number of iterations and dependency on cooling schedule and stopping criteria. In this paper, with the modification of annealing process and stopping criteria, a MSA algorithm is presented in the form of two phase annealing process for optimal seismic design of braced structures. The performance of the proposed algorithm has been illustrated in detail.
청소년의 성별에 따른 Cortisol 분비의 일주기 차이 : 반복측정에 따른 Area Under the Curve 분석법 사용
이상관,Lee, Sang-Kwan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4
Purpose : This study investigated the diurnal rhythm of cortisol in male and female adolescents. Methods : Salivary cortisol was examined in 52 normally developing subjects aged 13 to 14 years. Subjects provided saliva samples at 08:00h, 12:00h, 16:00h and 20:00h. Results : Males and females showed similar pattern of cortisol, which elevated cortisol in the morning and decreased in the evening. There were no differences of gender at 08:00h, 12;00h and 20:00h. There were also not difference between males and females using an area under the curve analysis. Conclusions : The same diurnal cortisol rhythm were found in male and female adolescents. Further research is needed to examine differences of gender in cortisol awakening response.
김소연,이상관,Kim, So-Yeon,Lee, Sang-Kwan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2
Objectives : The weekly variation of ischemic stroke incidence according to the age and sex. Methods : 977 consecutively admitted patients (521 males and 456 females) in a single stroke center from 2006 to 2008. All cases were confirmed with standardized criteria. We used the independent t-test and $x^2$ test in statistical methods. Results : The results demonstrated significant weekly variations of ischemic stroke incidence showing higher incidence on Saturday, Monday and Tuesday and lower incidence on the other days. Difference of ischemic stroke incidence was also shown between transit days, which included the transit days from the weekend to the week and vice versa, and non-transit days. Those aged older than 60 years and females showed more significant differences of weekly variation on transit days than on non-transit days. Conclusions : Ischemic stroke incidence has significant weekly variation, and transit days have higher incidence than non-transit days. Further study is required to identify the general weekly variation by multi-center trial.
뇌졸중 후 우울증에 대한 황련해독탕 약침의 안전성 및 유효성 평가를 위한 임상 시험
제준태,이상관,Je, Jun-Tae,Lee, Sang-Kwan 대한약침학회 2010 Journal of pharmacopuncture Vol.13 No.2
Objective : The purpose of this study is to determine the efficacy and safely of Hwangryunhaedok-tang Pharmacopuncture (HHT-PA) therapy on post-stroke depression (PSD) in stroke patients. Methods : Fifteen PSD patients has been recruited and evaluated with liver function test (LFT) and renal function lest (RFT) and depression scales, Beck Depress ion Inventory (BDI) and Hamilton Depression Rating Scale (HAM-D) before and after HHT-PA treatment. Results : HAM-D score significantly decreased after HHT-PA treatment regard less of improving of motor function. But BDI score did not decrease significantly. All results of LFT and RFT were in normal range before and after HHT-PA treatment Conclusion : These results showed that HHT-PA decrease PSD symptoms and has safety on stroke patients, although has no effect on improving of motor impairment.