아프타성 구내염 치료용 구강 패취의 설계 : 약물층

이규현,박은석,지상철 ( Kyu Hyun Lee,Eun Seok Park,Sang Cheol Chi ) 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4

For the effective treatment of aphthous stomatitis, the matrix type mucoadhesive patches containing triamcinolone acetonide have been formulated. The drug layer was obtained by drying the polymer gel which was prepared with carbomer 934P, ammoniomethacrylate copolymer, titanium dioxide and polyethylene glycol 400. The effects of the content of additives on physical characteristics of the polymer gel and the drug layer were evaluated. The addition of carbomer increased the yield point and the zero-shear viscosity of polymer gel as well as the thickness, the water absorption ratio, the adhesive time and T_(50%) of drug layer. The adhesive time and the water absorption ratio of drug layer were also improved by the addition of ammoniomethacrylate copolymer, but the addition of titanium dioxide had decreased the zero-shear viscosity of polymer gel and the adhesive time of drug layer.

진무탕(眞武湯)이 Gentamicin-유도 신독성에 미치는 영향

이규현,김길훤,Lee, Kyu-Hyun,Kim, Gil-Whon 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2

Aminoglycosides, including gentamicin, have been used as antibiotics for the various infections by gram-negative bacteria. However, there are some restrictions for using these drugs. Gentamicin, a typical aminoglycoside, has the side effect of nephrotoxicity, including polyuria, glycosuria, proteinuria, glomerulonephritis, and uremia. The aims of this study were to examine the prevention or reduction effects of Jinmootang on the gentamicin-induced nephrotoxicity and to investigate the possible mechanisms on the effect of Jinmootang. The subcutaneous injections of 60mg of gentamicin per kg of boby weight to Sprague-Dawley rats for 8 days induced typical symptoms of nephrotoxicity by aminoglycosides. 0.6ml of water extract Jinmootang (100ml/chup) was orally treated in the experimental animal. 24-hour urine was collected with the metabolic cage and plasma was sampled from the abdominal aorta. The plasma concentration of sodium was significantly decreased by the treatment of gentamicin but it was not-significantly changed by the treatment of Jinmootang to the animal. The concentration of potassium was greatly decreased in the gentamicin-treated animals. However. it was returned to the normal level in the Jinmootang-treated animals. The concentrations of creatinine and urea were increased by gentamicin treatment. But, Jinmootang reduced these concentrations. Nevertheless, the osmolalities of plasma in both group were not different from each other. Even though the plasma concentration of aldosterone was not significantly changed, the mean value was increased by the gentamicin intoxication. The concentration of aldosterone was decreased by the treatment of Jinmootang. The reduction of aldosterone level in plasma could be a factor to improve the hypokalemia. The fractional excretion of potassium was much higher than normal by the treatment of gentamicin and it was decreased by 50% in the Jinmootang-treated rats. Therefore, the reabsorption of potassium was significantly increased by the treatment of Jinmootang, even though the filtered load of potassium in the experimental group was much highter than control. Even though the concentration of plasma aldosterone was decreased by the treatment of Jinmootang, the fractional excretion of sodium was not increased, slightly lower. These data suggested that Na reabsorption was increased in the proximal tubule by Jinmootang. The filtered load of glucose in the Jinmootang-treated group was greater than in control. Nevertheless, the fractional excretion of glucose in the experimental group was not different from that in control. These results indicate that glucose reabsorption was increase in the proximal tubule by Jinmootang treatment. The results of this study suggest that Jinmootang could improve the some nephrotoxic symptoms induced by gentramicin treatment. Hypokalemia, the reduced glomerular filtration rate, and dysfunctions of renal proximal tubule and distal nephron were significantly recovered to normal level. The increase of glomerular filtration rate by Jinmootang might contribute to eliminate the waste product, including creatinine and urea, and/or gentamicin through the kidney.

한류의 확산과 저항

이규현(Kyu Hyun Lee) 한국마케팅과학회 2006 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

고정화효소와 그 이용

이규현(Kyu Hyun Lee),김계용(Kea Yong Kim) 한국고분자학회 1984 폴리머 Vol.8 No.3

왜 우리는 타인들과 함께 행동하는가: 목표지향행동과 집단정체감

이규현(Lee, Kyu Hyun),리차드 바고찌(Richard P. Bagozzi) 한국소비문화학회 2009 소비문화연구 Vol.12 No.4

소비자행동은가족, 친구, 동료들사이에서소집단행동으로나타나는경우가많다. 본연구는이러한소집단에 서소비자들이왜함께행동하려는의도를가지는가에대한의도적사회행위(intentional social action)를 이해하기위해서어떠한예측치들이설명력이높은가에관심을가지고연구하였다. 소비자들이함께행동하려 고할때, 암묵적이거나명시적으로공동목표를가지고행동하려고한다. 그리고그들이소속하고있는집단에 정체감을형성하고있기때문에본연구는목표지향행동과집단정체감을중심으로소집단에서함께행동하려는 의도에어떠한행동요소들이결정적으로영향을미치는가를분석하였다. 이와같이목표지향상황에서함께행동하려는의도에영향을미치는변수들은계획된행동이론의예측치들인 태도, 주관적규범, 지각된행동통제에첨가하여성공에대한기대와실패에대한기대를표현하는긍정적기대 감정과부정적기대감정을포함시켰다. 이들이태도와주관적규범과함께욕구에영향을미친다고보았다. 그 리고과거행동과집단정체감이욕구와의도양쪽에영향을미친다는모형을개발하여실증적검토를하였다. 실증적분석은LISREL을사용하면서구조방정식모형으로분석하였다. 목표지향행동모형에서포함시키지않 은집단정체감변수를포함하여분석한목표지향행동과집단정체감결합모형분석에서집단정체감의효과는한 국자료에서는뚜렷하게나타났으나, 미국자료에서는전혀나타나지않았다. 이러한실증적결과는집단정체감의측정요소들인인지적, 감정적, 평가적요소들이한국소비자들의의도적사 회행위에서매우중요하게작용하는요소로서이에집중된마케팅믹스전략을수립할필요성이있음을시사한 다. 특히, 한국에서소비자들을대상으로마케팅을하는기업들의경우, 집단정체감을강조한제품개발과확산 전략이타당하지만, 미국의경우는그렇게효율적이아닐수있음을시사한다. 이러한소집단행동에서목표지 향행동과집단정체감에관한연구는앞으로온라인공동체, 브랜드공동체등공동체행동연구와관련하여연구 를확장할수있다. 또한한국과미국뿐만아니라일본과중국소비자행동연구로확장할필요가있다. To explain intentional social behavior in small group, we construed intentions to apply to the group setting and developed two major models to explain consumers’ goal-directed behavior. One is the model of goal directed behavior and the other model is the model of goal directed behavior plus group identification. To develop these models, we added five variables based on the theory of planned behavior. These variables include anticipated positive emotion, anticipated negative emotion, past behavior, desire, group identification. In the first model, anticipated emotion elicited by the prospects of goal success and/or goal failure affects desire, and desires affects we-intention. In the second model, group identification affects desire and we-intention. An empirical study is conducted to compare Korean data with American data. Sample is taken from 180 Korean undergraduate students and 130 American undergraduate students to understand goal directed behavior in restaurant choice. Data are analyzed by structural equational modeling using LISREL. We found that in Korean data, group identification is a significant predictor in group intentions under suggested model. However, in American data, this is not a predictor at all. This result shows that group identification is a determinant factor to understand goal-directed behavior in interdependent society such as Korea. This study shows that the connection of goal-directed behavior and group identification represents a topic of immense potential for understanding small group behavior in interdependent society like Korea. The findings of this study are applicable to group behavior of other country like Japan and China. This study is limited to restaurant choice behavior. The findings are applicable to other choice behavior like leisure, shopping ,traveling, and group behavior in brand community.

Causes of Consumer Ethnocentrism and Its Effects on Attitude and Behavior of Chinese Young Generation

Kyu-Hyun Lee(이규현),Yu Du(두우) 국제e-비즈니스학회 2012 e-비즈니스 연구 Vol.13 No.4

차등서비스 코드의 분석 및 다양한 활용을 위한 라이브러리 구현

이규현(Kyu Hyun Lee),김대영(Dae Young Kim) 한국통신학회 2000 한국통신학회 학술대회논문집 Vol.2000 No.7

기술상용화시대의 도래 - 클러스터와 네트워크의 진화

이규현(Lee Kyu Hyun) 한국마케팅과학회 2005 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

온라인과 오프라인 컨버전스 마케팅 - 공동체 형성과 발전을 중심으로 : 온라인과 오프라인 컨버전스 마케팅

이규현(Lee Kyu Hyun),이선숙(Sun Suk Lee) 한국마케팅과학회 2006 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

태도의 사회적 영향력

이규현(Lee, Kyu Hyun),리차드 바고찌(Richard P. Bagozzi) 한국소비문화학회 2009 소비문화연구 Vol.12 No.1

본 연구는 집단의도의 개념을 새로이 정의하고, 태도이론들과 사회정체감이론들에서 나타난 아이디어들에 기반을 두어 집단의도를 설명해주는 통합적인 모형을 제시하였다. 두 번의 실증적 연구들을 통해 집단정체감이 상호의존적인 문화와 독립적인 문화에서 살고 있는 사람들의 집단의도를 더 잘 설명해 주고 있다는 가설들을 증명하였다. 첫 번째 연구에서 집단정체감은 자기범주화와 감정적 몰입으로 측정하였고, 이 집단정체감은 합리적 행동이론에서 다룬 예측변수들보다 집단의도에 대한 설명력을 훨씬 증가시켜주었다. 이는 미국인들(N=100)에게서 보다 한국인들(N=142)에게서 더욱 크게 나타났다. 두 번째 연구에서 집단정체감은 자기범주화, 감정적 몰입, 그리고 집단 자존감으로 측정하였는데, 이 집단정체감은 계획된 행동이론에서 다룬 예측변수들 보다 집단의도에 대한 설명력을 훨씬 더 증가되었다. 이 또한 미국인들(N=130)에게서 보다 한국인들(N=182)에게서 더욱 크게 나타났다. 본 연구는 상호의존적이고 독립적인 문화지향에서 나타나는 자아구성이 집단의도에 중요한 영향을 미칠 수 있다는 것을 보여주었다. 본 연구는 국가와 국가 사이에서 문화비교를 하였지만 미래연구는 국내에서 자아구성의 차이가 집단의도에 미치는 영향을 측정하고 탐구하는 연구들이 여러 행동분야에서 다양하게 나타날 필요가 있다. The concept of group intentions is defined, and a series of models are used to explain group intentions based on ideas from attitude and social identity theories. Two studies provided support for the proposal that group identification explains group intentions better for people in interdependent-versus independentbased societies. Study1 showed that group identification (measured by self-categorization and attachment) significantly increased the variance explained in group intentions over and above the predictors in the theory of reasoned action, and this occurred to a significantly larger extent for Koreans (N=142) than Americans (N=100). Study 2 also found that group identification (measured by self-categorization, attachment, and collective self-esteem) significantly increased the variance explained in group intentions over and above predictors in the theory of planned behavior, and this again occurred to a significantly larger extent for Koreans(N=182) than Americans(N=130). This paper showed that self-construal as implied in interdependent versus independent cultural orientations can have important effects on decision making. Future research should measure and investigate self-construals directly rather than relying on country of origin as this paper did.