고밀도 광 기록 장치에서 비터비 트렐리스의 가지 메트릭을 이용한 부분 응답 적응 등화기

이규석,이주현,이재진,Lee, Kyu-Suk,Lee, Joo-Hyun,Lee, Jae-Jin 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.9C

본 논문에서는 비대칭적인 채널 특성을 갖는 고밀도 광 기록 시스템에 적용 가능한 적응 등화 부분 응답 최대유사(partial response maximum likelihood, PRML) 검출 방법을 제안한다. 모의실험을 통해 비대칭적인 채널에서 제안한 PRML 검출 방법이 기존의 PRML 방법보다 성능이 향상되는 것을 확인하였고, Verilog HDL을 이용하여 구현 및 검증하였다. 본 논문에서 제안한 적응 등화기는 LMS(Least Mean Square error) 알고리즘을 이용한 탭 계수 갱신부와 FIR 필터로 구성되어 있다. FIR 필터는 속도 향상을 위해 일반적으로 이용되는 DF(Direct Form) 방식이 아닌 TDF(Transposed Direct Form) 방식을 이용하여 구현하였다. 또한, 검출기는 레지스터 변환(register exchange, RE) 방식을 이용한 비터비 검출 방법으로 구현하였다. In this paper, we propose an improved partial response maximum likelihood (PRML) detection scheme that has an adaptive equalizer and can be applied in the asymmetric optical recording system with high-density. We confirmed that the proposed PRML detector improves detection performance. In addition, we implemented the detector by Verilog HDL. The adaptive equalizer is composed of tap coefficient updating unit using LMS algorithn and FIR filter. FIR filter is implemented by the transposed direct form architecture for high speed operation. Viterbi detector is implemented by the register exchange method.

편평상피세포암에서 Laminin B1 유전자의 발현조절

이규석,노용지,송준영 ( Kyu Suk Lee,Yong Ji Rho,Joon Young Song ) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2

고밀도 비선형 광 저장장치를 위한 새로운 부분응답 최대유사도 신호 검출 기술

이규석,이재진,Lee, Kyu-Suk,Lee, Jae-Jin 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.10C

본 논문은 고밀도 광 기록 저장장치에서 오류의 주 원인이 되는 tangential tilt의 문제를 해결하기 위한 개선된 부분응답최대유사도 신호 검출 방법을 제안한다. 틸트의 변화에 따라 등화기 계수와 비터비 디코더의 가지 기준값을 적응적으로 갱신하여 채널의 변화에 잘 적응하도록 하였다. 채널의 변화를 감지하는 요소로 주기적으로 반복되는 데이터의 동기패턴을 이용하여 누적 평균을 취한 후 변화량에 해당되는 등화기 계수값과 비터비 디코더의 가지 기준값을 동시에 갱신한다. 제안된 방법을 적용한 결과 기존의 PRML 검출기에 비해 비트 오류율 10-6에서 최대 4dB이상 성능이 향상되는 것을 확인할 수 있었다. We Propose a partial response maximum likelihood(PRML) detection method that improves the performance of the high-density optical storage system. It concurrently adjusts the coefficient of equalizer and reference values of branches in Viterbi detector. For the estimation of asymmetric channel characteristics by the tangential tilt, we exploit sync patterns in each data frame. The simulation result shows it improves the Performance up to 4dB at 10-6 BER compared to conventional adaptive PRML.

고밀도 비선형 광 저장장치를 위한 새로운 부분응답 최대유사도 신호 검출기 구현

이규석,이재진,Lee, Kyu-Suk,Lee, Jae-Jin 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.11C

본 논문에서는 고밀도 광기록 장치에서 발생하는 디스크 기울임 현상으로 인한 검출 성능 저하를 방지하기 위해서 디스크 기울임 분석기를 갖는 적응 등화 PRML 검출 방법을 VerilogHDL을 이용하여 구현하였다. 디스크 기울임의 분석을 위하여 고정된 패턴으로 일정한 간격마다 반복되는 동기 데이터를 이용하여 분석된 디스크의 기울임 정도를 측정하여 ROM에 저장된 등화기 계수값과 가지 메트릭의 기준값을 갱신한다. 이러한 방법은 지속적으로 계수값을 계산하여 갱신시켜줘야 하는 기존의 적응등화 방법에 비해 간단하게 각각의 계수값을 갱신시킬 수 있다. Hynix $0.35{\mu}m$ STD cell library로 회로를 합성한 결과 35K 정도의 게이트를 필요로 하고 최대동작속도 140MHz의 성능을 보였다. The implement the adaptive partial response maximum likelihood (PRML) detector with tilt analyzer for asymmetric high-density optical storage system. For the estimation of disc tilt, we exploit spc patterns in each data frame. Because of using the ROM table to renew the coefficients of equalizer and reference values of branches, the complexity of the hardware is reduced. The proposed PRML has been designed and verified by VerilogHDL and synthesized by the Synopsys Design Compiler with Hynix $0.35{\mu}m$ STD cell library. In the result, the total gate count is 35K, and the maximum operating frequency is 140MHz.

산 처리한 순환골재를 사용한 순환골재 콘크리트의 강도특성에 관한 연구

이규석,김용재,박제영,성병길,박철우,심종성 한국구조물진단유지관리학회 2011 한국구조물진단학회 학술발표회논문집 Vol.2011 No.9

This study is intended to assess the usability of recycled aggregate which is produced by wastes-concrete. It analyzes the quality of the recycled aggregate which is produced through the acid treatment process. The conclusions of the study are as follows. The absorption and the specific gravity of acid treated aggregates (both fine and coarse) was found much better than the ordinary recycled aggregates. The concrete made by incorporating acid treated aggregates exhibited higher compressive strength at all ages as compared to the concrete produced by using ordinary recycled aggregates.

교원질 유전자의 발현 조절

이규석 (Kyu Suk Lee) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Background : The Ingram regimen has been advocated for t.he treatment of psoriasis. It is an effective therapeutic moiality, but its complexity and frequent side reactions have restricted its use for therapy. There are several modified Ingrarn regimen, change of vehicle, shortening of application time, low-strerigth anthralin, combination with emollient. Previously, we have reportved the effectiveness of mocified Ingram regimen for psoriasis, however, the remission time and relapse rate of psoriasis h;is not been reported in Korea. Objective : This study was performed to evaluate the efficacy of the modified Ingram region for the treatment of psoiasis and the remission time and relapse rate of psoriasis following moclified Ingram therapy. Methods : Sixty patients with plaque-form psoriasis were treated with the modified Ingra,n therapeutic regimen. They were divided into two groups, a moderate group which included 39 patients, and 21 patients in a severe group. Results : The follwing results were obtained from this study. 1. Among 60 patients, 52 patients(86.6%) were successfully healed and 8 patients(13.3%) showed failure in their t eatment. 2. In 52 patients, 44 patients(73.3%) showed a clearing of psoriasis, 8 patients(13.3%) showed some improvement. 3. In 44 cleared patients mean numbers and duration of therapy reaching grade 4 were 13.0 and 21.0 days for the trunk and 15.1 and 24.7 days for the extremities, the difference was not significant statistically(p>0.05). The difference between the total dose in trunk and extremitis was significant statistica,ly(p<0.05). 4. In 44 cleared patients mean numbers, duration and total dose of therapy reaching grade 4 in the severe group were significantly higher than those in the moderate group (p<0.05). 5. There were some rotable side effects such as staining(17.3%), erythema(15.4%) and pruitus(13.5%), but in no case therapy was terminated. 6. According to the everity in 33 of the cleared patients, we observed 10 patients(17.4%) with early relapse((6 months), 7(21.7%) with late relapse(>6 months) and 14(60.9%) with riorelapse(>12 months) in the moderate group and also observed 10 patients(70.0%) with early IP, lapse, 2(20.0%) with latrelapse and 1(10.0%) with no relapse in the severe group. 7. In 33 pat,ients who were followed up at least one year later, the mean time of remission was 31.4 months in the moderate group and 6.0 mont,hs in the severe group. There were signilicant differences in the two groups(p<0.05). Conclusion : The results of this study suggest that the modified Ingram regimen is one of the effective therapeutic mocialities for cases of moderate psoriasis. (Kor J Dermatol 1995;33(6): 1014-1020)

경피증 섬유아세포에서의 세포외 기질 유전자의 발현

이규석(Kyu Suk Lee),김석주(Seok Ju Kim),서민호(Min Ho Suh),송준영(Joon Young Song) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.3

Scleroderma is a connective tissue disease characterized by excessive accumulation of collagen in skin and visceral organs due to increased collagen production by scleroderma fibroblasts. The basic etiology of this collagen accumulation is not known. We examined the expression of various extracellular matrix genes in cultured fibrolasts using Northern blot and slot-blot hybridization. The scleroderma fibroblasts exhibited characteristic mRNA size of extracellular matrix genes and prominanty increased type I and III procollagen mRNAs levels compared to control fibroblasts cultures from univolved skin. The ratios of type I /IE procollagen in scleroderma cell lines were not so much different to the controls. These results indicate that increases of collagen biosynthesis in scleroderma can be a accounted for, at least in part, by an increased content of transcriptable type I and type JE procollagen mRNAs, both. (Kor J Dermatol 29(3): 322 330,1901)

Modified Mohs surgery에 의한 기저세포암 치험

이규석(Kyu Suk Lee),김석주(Seok Ju Kim),송준영(Joon Young Song) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3

Modified Mohs surgery is a procedure which eliminated chemical fixation step from Mohs chemosurgery. This technique is faster, less painful and more tissue conserving, allows for immediste repairs, yields higher quality histologic preparations and facilitates an interdisciplinary apporoach; it is the treatment of choice for recurrent or difficult skin cancers. A 58-year-old femele patient presented with a 2x 3cm sized dark brownish, ulcerated nodule on the left upper eyelid. Histopathologic findings revealed several small solid nest composed of basalioma cells in the dermis. We treated with modified Mohs surgery and obtained good result. (Kor J Oermatol 2S(3): 390 393, 1990)

고등학교 지구과학 교육과정 기본 모형 연구

이규석(Kyu Suk Lee) 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1

편평상피암에서의 c - myc , erb B 및 EGF - Receptor 유전자의 세포 - 분자생물학적 특성

이규석 ( Kyu Suk Lee ),규영욱,최윤애 ( Yoon Yae Choi ),송준영 ( Joon Young Song ),최인장 ( In Jang Choi ),장성익 ( Sung Ik Jang ),백원기 ( Won Ki Baek ),서민호 ( Min Ho Suh ) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.2

Background : Oncogenes and EGF-Receptor(EGFR) may be involved n different stages of the multistep carcinogenesis process. A specific pattern of karyotypic abnormalities in solid tumors can be detected by cytogenetic methods. Onjective : This study is intnded to observe the cytomolecular kiologic chracterization of c-myc, erb B and EGFR genes in squasnous cell carcinoma(SCC) of the skin and cervix. Methods : We have eytogenet,ically examined the short-term culturs from SCC. The rearrangement, amplification or expressi.on of erb B, c-myc, and EGFR genes were studied by Southern blot, analysis of genomic DNA and by slot blot analysis of tota! RNA extracted from biopsies of normal skin and SCC tissues. EGFR expression was examined immunohistochemially using monoclonal antibodies and the localizat,ion of the c-myc oncogene mRNA by in situ hybridization. Results : A remarkably structural aberration was del 6(q21-qter) counted 20 metaphases among 28 metaphases ana1yzed. In nunierical aberration, all chromosomes were lost or gained randomly. Amenploid including triploid and tetraploid were observed in 8 metaphases, 6 tumor cells contained marker chromosome. In Southern blot analysis, rearrangement and amglificaton of EGFR in primary squamous cell carcinoma of cervix uteri and skin respectively. In slot blot analysis, the levels of c-myc, erb B and EGFR mRNA increaaed respectively 3.5, 2.5 and 2.8 times in SCC when compared to normal tissues. In immunoperoxidase stain, EGFR was present, in SCC where keratinocytes with strong cyto-plasmic staining but no membr, line labelling, where as in normal skin the were primarily present in t,he membrane and cytoplasm of basal cells. In situ hybridization with c-myc cDNAs allowed detection of grains representative of biotin labelled cDNA-mRNA hybrids in the frozden section of SCC tissues. Conclusion : These results suggest that specific patterns of karyotypir abnormalites, rearrangement, or amplification of EGFR gene, and overexpression of oncogenes and EGFR gene may be associated with the carcinogenesis of SCC. (Kor J Dermatol 1994; 32(2): 223-233)