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마우스에서 L-Theanine의 기억력 회복능 및 Acetylcholinesterase 활성 억제
육동연,김태일,박상기,박형국,윤여경,홍진태,Yuk, Dong-Yeon,Kim, Tae-Il,Park, Sang-Gi,Park, Hyoung-Kook,Yoon, Yeo-Kyeung,Hong, Jin-Tae 대한약학회 2007 약학회지 Vol.51 No.6
Acetylcholinesterase (AChE) plays a role in the progression of Alzheimer's disease (AD). In this study, we examined the improving effect of L-theanine, a major amino acid in Japanese green tea (Camellia sinensis) on the scopolamine (1 mg/kg/mouse)-induced memory dysfunction in mice. Treatment with L-theanine (2, 4 mg/kg/mouse p.o.) in the drinking water for 7 days reversed the scopolamine-induced latency time and distance in the water maze test, latency time in the passive avoidance test, and inhibited AChE activity. This study suggests that L-theanine may be a useful agent for prevention of progression of AD.
녹차추출물/L-Theanine 혼합물의 Secretase 활성 억제 및 세포사 억제를 통한 기억력 회복능
김태일,육동연,박상기,박형국,윤여경,홍진태,Kim, Tae-Il,Yuk, Dong-Yeon,Park, Sang-Ki,Park, Hyoung-Kook,Yoon, Yeo-Kyeung,Hong, Jin-Tae 대한약학회 2008 약학회지 Vol.52 No.5
We examined the effect of green tea extract (GTE) and L-theanine combination on the $A{\beta}_{1-42}$-induced memory dysfunction. GTE and combination were administrated into mice for 3 weeks followed by injection of $A{\beta}_{1-42}$ to induce memory impairment. GTE and L-theanine administration significantly improved cognitive ability and reduced $A{\beta}_{1-42}$ level accompanied with the inhibition of neuronal cell death and activities of secretase. These results suggest that GTE and L-theanine combination may be a useful for preventing for the development or progression of Alzheimer's disease.
유기 음이온계 약물의 간내 이행과정에 있어서 Cytoskeleton의 역할에 관한 속도론적 연구
정연복,한건,육동연,Chung, Youn-Bok,Han, Kun,Yuk, Dong-Yeon 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.1
The effects of colchicine on the plasma elimination and biliary excretion of various organic anions in rats were examined. Elimination of indocyanine green (ICG) or rose bengal (RB) from plasma was significantly delayed when rats were treated with colchicine (3 mg/kg body weight) 3 hr prior to the administration of the dye. On the other hand, disappearance of sulfobromophthalein (BSP) or bromophenol blue (BPB) from plasma was not influenced by colchicine. The plasma disappearance and biliary excretion of organic anions were kinetically analyzed based on a compartment model, in which the deep compartment and the unknown disposition are incorporated. The transfer rate constants of ICG or RB, $k_{23}$ (from the liver to the deep compartment) and $k_{3B}$ (from the deep compartment to the bile), were decreased by colchicine, but those of BSP or BPB were not changed. A mechanism for the decrease in the $k_{23}$ and $k_{3B}$ values for ICG and RB might be explained by a inhibition of colchicine to the intracellular cytoskeleton. The hepatocellular distribution of RB or BPB was then determined. BPB mainly distributed to the cytosolic fraction, but RB distributed to each hepatocyte organelle. Taken together. it was suggested that ICG or RB is transported through hepatocytes into bile with the aid of the cytoskeleton, whereas BSP or BPB is handled by hepatocytes in a different way.
유기 음이온계 약물의 간내 이행과정에 있어서 Cytoskeleton 의 역할에 관한 속도론적 연구
한건,정연복,육동연 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.1
The effects of colchicine on the plasma elimination and biliary excretion of various organic anions in rats were examined. Elimination of indocyanine green (ICG) or rose bengal (RB) from plasma was significantly delayed when rats were treated with colchicine (3 ㎎/㎏ body weight) 3 hr prior to the administration of the dye. On the other hand, disappearance of sulfobromophthalein (BSP) or bromophenol blue (BPB) from plasma was not influenced by colchicine. The plasma disappearance and biliary excretion of organic anions were kinetically analyzed based on a compartment model, in which the deep compartment and the unknown disposition are incorporated. The transfer rate constants of ICG or RB, k_(23) (from the liver to the deep compartment) and k_(3B) (from the deep compartment to the bile), were decreased by colchicine, but those of BSP or BPB were not changed. A mechanism for the decrease in the k_(23) and k_(3B) values for ICG and RB might be explained by a inhibition of colchicine to the intracellular cytoskeleton. The hepatocellular distribution of RB or BPB was then determined. BPB mainly distributed to the cytosolic fraction, but RB distributed to each hepatocyte organelle. Taken together, it was suggested that ICG or RB is transported through hepatocytes into bile with the aid of the cytoskeleton, whereas BSP or BPB is handled by hepatocytes in a different way.
유리간세포를 사용한 ANS 의 간내 이행에 관한 연구 : ANS 의 간내 이행과정에 단백질 매개 기구가 존재하는가 ?
한건,정연복,육동연 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.1
The hepatic uptake of an anionic fluorescence probe, 1-anilino-8-naphthalene sulfonate (ANS) was characterized using isolated rat hepatocytes. The initial uptake rate of ANS by isolated hepatocytes was determined. The uptake process of ANS was fitted well to the Michaelis-Menten equation with a saturable component. The V_(max) and K_m values were 2.9±0.1 n㏖/min/㎎ protein and 29.1±3.2 μM, respectively. The uptake clearance (CL_(up)) based on the ratio of V_(max) to K_m was 11.7 ㎖/min/g liver, revealing the good coincidence with that assessed from the analysis of the plasma disappearance curve in previous report. Forthermore, the effect of serum protein on the hepatic uptake of ANS into isolated hepatocytes was investigated. The permeability clearances (PS_(inf)) of ANS uptake were much higher than those predicted based on the unbound fractions in the presence of serum. These suggested that the hepatic uptake of extensively serum protein-bound ANS is mediated not only by the unbound form of ligand but also by the serum protein-mediated uptake mechanism.