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柳泰錫 진주농과대학 1964 진주농과대학 연구논문집 Vol.- No.3
In the central nervous systen, an antagonistic action between strychnine and chloral hydrate, and the therapeutic effects of the various compounds, namely, strychnine, strychnine-atropine-caffeine, strychnine-Atropine-Adrenaline, and strychnine-atropine-pituitrin as the antidoters for the chloral hydrate intoxication were studied. For the purposes, a LD50 of chloral hydrate and strychnine for the various test animals were determined. The test animals used were frog, chichen, digs, goats, and rabbits. The animals were received, via the intravenous route, one LD50 of chloral hydrate and followed by the subcutaneous injection of one, one and half, two and three LD50 of strychnine and the above mentioned compounds. the following observations were made. Those are motality, time required for the recovery, respiration rate, puls, body temperature and an optimum doses of the antidotic agents. The following results were obtained. 1. In the simultaneous or individual administration of chloral hydrate and strychnine, in amount of one LD50 resulted of the symptoms which are predominant as seen in the case of chloral hydrate intoxication but not seen in strychnine. 2. In the comparative action of the antidotes, namely strychnine-atropine-adrenaline, strychnine-atropine-caffeine, strychnine, the former showed the best result.
유태석,이광웅,이남준,최영록,김혜영,서석원,정재홍,이정무,서경석 대한의학회 2016 Journal of Korean medical science Vol.31 No.7
Pretransplant alpha-fetoprotein (AFP) is a useful tumor marker predicting recurrence of hepatocellular carcinoma (HCC). Little is known, however, about the relationship between changes in AFP concentration and prognosis. This study investigated the clinical significance of change in peri-transplant AFP level as a predictor of HCC recurrence. Data from 125 HCC patients with elevated pretransplant AFP level who underwent liver transplantation (LT) between February 2000 and December 2010 were retrospectively reviewed. Patients with AFP normalization within 1 month after LT were classified into the rapid normalization group (n = 97), with all other patients classified into the non-rapid normalization group (n = 28). Tumor recurrence was observed in 17 of the 97 patients (17.5%) with rapid normalization; of these, 11 patients had high AFP levels and six had normal levels at recurrence. In contrast, tumor recurrence was observed in 24 of the 28 patients (85.7%) without rapid normalization, with all 24 having high AFP levels at recurrence. Multivariate analysis showed that non-rapid normalization (harzard ratio [HR], 4.41, P < 0.001), sex (HR, 3.26, P = 0.03), tumor size (HR, 1.15, P = 0.001), and microvascular invasion (HR, 2.65, P = 0.005) were independent risk factors for recurrence. In conclusion, rapid normalization of post-LT AFP level at 1 month is a useful clinical marker for HCC recurrence. Therefore, an adjuvant strategy and/or intensive screening are needed for patients who do not show rapid normalization.