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식물추출물 마늘 추출액, 잔톡실럼 정유, 레몬그라스 정유 함유 유제 3종의 생태독성평가
유아선(Are-Sun You),홍순성(Mihye Jeong),정미혜(Soon-Sung Hong),박경훈(Kyung-Hun Park),장희섭(Hee-Seop Chang),이제봉(Je Bong Lee),박재읍(Jae-Yup Park) 한국농약과학회 2012 농약과학회지 Vol.16 No.4
Environment-friendly agro-materials are are likely to be preferred to chemical insecticides recently. For this reason, many studies are conducted to develop environment-friendly insecticides containing natural materials. This study was also conducted so as to assess ecotoxicity for Emulsifiable concentrate (EC) containing 30% of garlic extract or two plant essential oils (Zanthoxylum, Lemongrass) expected to prevent from pests and be used for agro-materials. Target species used to assess acute toxicity were invertebrate (Daphina magna), fish (Oryzias latipes), honeybee (Apis mellifera L.) and earthworm (Eisenia fetida). The EC<sub>50</sub> values for of garlic extract 30% EC, Zanthoxylum oil 30% EC and lemongrass oil 30% EC to Daphina magna were 3.3, 10, and 10 mg L<sup>?1</sup>, respectively. The category of garlic extract 30% EC was moderately toxic, while those of Zanthoxylum oil 30% EC and lemongrass oil 30% EC were slightly toxic according to standard of USEPA. EC<sub>50</sub> for both of Zanthoxylum oil 30% EC and lemongrass oil 30% EC were more than 10 mg L<sup>?1</sup> then they were considered as slightly toxicity. In case of acute toxicity test to fish, LC<sub>50</sub> of garlic extract 30% EC was 3.3 mg L<sup>?1</sup>. Zanthoxylum oil 30% EC and lemongrass oil 30% EC indicated LC<sub>50</sub>> 10 mg L<sup>?1</sup>. Classification of acute toxicity to all test substances was in Korea criteria. Acute contact and oral toxicity test to Honeybee were conducted. As a result, LD<sub>50</sub> of all test substances were more than 100 a.i. μg bee<sup>?1</sup> in the acute contact test while LD<sub>50</sub> of garlic extract 30% EC was 4.4 a.i. μg bee<sup>?1</sup> and LD<sub>50</sub> of Zanthoxylum oil 30% EC and lemongrass oil 30% EC were more than 100 a.i. μg bee<sup>?1</sup>. In case of acute toxicity test to earthworm, LC<sub>50</sub> of garlic extract 30% EC, Zanthoxylum oil 30% EC and lemongrass oil 30% EC were 267, 592, and 430 mg kg<sup>?1</sup>, respectively. In conclusion, if the safety for earthworm is confirmed, these substances are expected to be use for environment-friendly insecticide materials with low risk against ecosystem and contribute to developing environment-friendly agro-materials.
농약 품목에 대한 GHS 기준과 농진청 기준에 따른 자극성 산출 후 자극성 분류 차이 비교
유아선(Are-Sun You),오진아(Jin A Oh),박수진(Soojin Park),조유미(Youmi Jo),이제봉(Je Bong Lee),이난희(Nanhee Lee),이주연(Ju Yeon Lee),임양빈(Yangbin Ihm) 한국농약과학회 2016 농약과학회지 Vol.20 No.4
GHS was compared with that of current RDA directives in skin and eye irritation for plant protection products (PPPs). According to the result of evaluation and classification of skin and eye irritation by RDA directives and GHS for 59 PPPs, 25.5% of PPPs were changed the classification of skin irritation from slightly and moderately by RDA directives to Not Classified by GHS, and 45.8% of PPPs were changed the classification of eye irritation from slightly by RDA directives to Not Classified by GHS. 6.8% of PPPs in skin irritation and 5.1% in eye irritation were classified more highly as category 1 by GHS because of irreversible effect. According to the result of comparison with GHS classification by data of irritation study for PPPs and by GHS classification and concentration of active substances, 25.5% was changed more lowly and 3.4% more highly in skin irritation, and 25.4% was changed more lowly and 11.9% more highly in eye irritation. It is needed to draw a plan to supplement for other results between GHS and RDA directives.
다양한 피부흡수율 default에 따른 농약살포 노출량 산출 및 농작업자 위해성 평가
유아선(Are-Sun You),이난희(Nanhee Lee),박수진(Soojin Park),조유미(Youmi Jo),오진아(Jin A Oh),이제봉(Je Bong Lee),박연기(Yeon-Ki Park),이주연(Ju Yeon Lee) 한국농약과학회 2017 농약과학회지 Vol.21 No.4
Occupational risk of plant protection products is assessed with Ko-POEM (tier 1, 2) and field data (tier 3) in Korea but default of dermal absorption is fixed as 10% in Korean guidance unlikely to EU guidance. In case of application of EU guidance, the risk was considered to increase because 10% dermal absorption is minimum default. physical characteristic and contents of active substances (a.s.) was investigated and default of dermal absorption was classified for 131 products according to EU guidance. It was investigated to change the operator risk through assessment by different default of dermal absorption with Ko-POEM. 22 case among 169 case (a.s.+content) were classified as 10% default of dermal absorption in mixing and application, 109 case as 25% and 38 case as 75% in mixing. As a result of assessment of 223 case for 131 products with Ko-POEM, 43 case with PPE were indicated the risk was high in Korean guidance and 121 case in EFSA guidance with Ko-POEM. 107 case with PPE among 121 case were indicated the risk was high with lower oral absorption than dermal absorption. The high risk assessed by the different default of dermal absorption was 2.5 times more than the high risk by only 10% default. Therefore, it is expected to increase requirement for field study or removal of application crops.
경구흡수율을 반영한 농약의 AOEL 설정 및 농작업자 위해성 평가
유아선(Are-Sun You),홍순성(Soonsung Hong),이제봉(Je Bong Lee),이승돈(Seungdon Lee),임양빈(Yangbin Ihm) 한국농약과학회 2014 농약과학회지 Vol.18 No.4
Methods of establishment of AOEL (Acceptable Operator Exposure Level), application of oral absorption by country, and calculation of exposure dose for operator risk assessment in USA, EU and Korea were investigated. Oral absorption of 141 active substances for pesticides was also investigated, then operator risk assessment was conducted with AOEL including oral absorption and Korean AOEL. Internal dose converted to external dose with oral or dermal absorption in USA and EU, but external dose to which oral absorption was not applied was used for establishment of AOEL in Korea. Oral absorption of 50 active substances among 141 were below 80%. In case of application of oral absorption as a correction factor in below 80%, AOELs of about 36% active substances were considered to be lower than the current Korean AOELs. Operator risk assessment of 28 active substances among 50 active substances with oral absorption below 80% was conducted with EU AOELs. TER (Toxicity Exposure Ratio) of 12 plant protection products including chlorothalonil WG (Water-dispersible Granule) was less than 1 and the risk was high. Operator risk assessment of 24 active substances among 50 active substances with oral absorption below 80% was conducted with Korean AOELs. TER of 6 plant protection products including chlorothalonil WG were less than 1 and the risk was high. Operator risk assessment of 4 plant protection products not having Korean AOEL was conducted with converted EU AOEL into AOEL not including oral absorption. The results indicated TER of 4 products including daminozide WP (Wettable Powder) was over 1 and risk was low. 22 products except 6 products such as oxadiagyl SC (Suspension Concentration) were shown the same results of risk assessment between EU AOELs and Korean AOELs. As a result, it was considered that AOELs including oral absorption was possible to be used for operator risk assessment. It was considered operator risk assessment with AOEL including oral absorption was more like real assessment method, and improvement of assessment was needed for application to evaluate pesticides in registration.
랫드와 HeLaTRE Cell에서의 Alachlor에 의한 갑상선 호르몬성 영향 연구
유아선(Are-Sun You),정미혜(Mihye Jeong),박경훈(Kyung-Hun Park),김병석(Byung-Seok Kim),김진배(Jin-Bae Kim),권오경(Oh-Kyung Kwon) 한국농약과학회 2008 농약과학회지 Vol.12 No.3
This study was designed to investigate the suitability of the pubertal assay and the enhanced TG 407 as methods for detection of endocrine-mediated effects, especially thyroid function. Male and female Sprague-Dawley rats were gavaged daily with 0, 12.5, 25, 50 ㎎/㎏ alachlor in com oil during 30 days. The effects of alachlor on thyroid gland, the genital organs and thyroid hormone were measured in male and female rats. Dose of alachlor 25, 50 ㎎/㎏/day increased relative weight of testis and thyroid gland in exposed male rats and decreased relative weight of vagina in exposed female rats. Relative weight of thyroid gland was decreased in alachlor 25 ㎎/㎏/day exposed female rats. Dose of alachlor 25, 50 ㎎/㎏/day decreased plasma T4 and testosterone in female rats. Another purpose of this study was to investigate the effects of endocrine disruptors as like thyroid hormone in vitro. Luciferase activity was measured to dectect reaction of test chemicals and thyroid hormone response elements in HeLaTRE cell. Dose of alachlor I nM-1000 nM increased 100-134% luciferase activity compared with control.
유아선(Are-Sun You),정미혜(Mihye Jeong),박경훈(Kyung-Hun Park),김병석(Byung-Seok Kim),이제봉(Je Bong Lee),최주현(Ju-Hyeon Choi),권오경(Oh-Kyung Kwon),김진화(Jin-Hwa Kim) 한국농약과학회 2007 농약과학회지 Vol.11 No.4
It is well known the functional foods are very useful to prevent serious diseases and promote health. Therefore, they are often called as nutraceuticals, designer foods, and pharmafoods, etc. Most of foods have diverse functions because they provide nutrients, energies and fibrinoid materials. When foods are taken in the body, they promote the biological defense system against diseases through the supply of the essential or healthy materials to human being's organs. The mode of action and functional foods in human body have not been clarified yet. Antioxidant is known as one of the therapeutic aids which can be reduced pesticide poisoning. Onion has a strong antioxidant effect. This study was carried out to elucidate an antioxidant function of onion by determination of superoxide dismutase in liver, lung, serum of male rat administered by intraperitonial injection of 0, 2, 4 ㎎ ㎏?¹ chlorpyrifos after administrated orally with onion for 6 weeks. Damage of liver and kidney was also investigated by biochemical analysis of serum(AST, ALT, BUN/Creatine ratio). SOD(superoxide dismutase) activity of onion-administrated group is higher than control group. In liver and lung, SOD activity of onion+chlorpyrifos administrated group is higher than only chlorpyrifos administrated group. BUN/Creatinine ratio of onion+chlorpyrifos administrated group was decreased compared with only chlorpyrifos-administrated group.
식물추출물 싸임화이트, 클로브버드, 계피, 라벤더, 레몬 유칼립투스 정유의 생태독성평가
유아선(Are-Sun You),최영웅(Young-Woong Choi),정미혜(Mi-Hye Jeong),홍순성(Soon-Seong Hong),박연기(Yeon-Ki Park),장희섭(Hui-Sub Jang),박재읍(Jae-Yup Park),박경훈(Kyung-Hun Park) 한국농약과학회 2011 농약과학회지 Vol.15 No.4
Environment-friendly agro-materials tend to be preferred to chemical insecticides recently. For this reason, many studies were conducted to develop environment-friendly insecticides containing natural materials. The purpose of this study was to assess ecotoxicity for 5 plant essential oils (Thyme white, Clove bud, Cassia, Lavender, Lemon eucalyptus) expected to prevent from pests and be used for agro-materials. Target species used to assess acute toxicity were aquatic invertebrate (Daphina magna), fish (Oryzias latipes), honeybee (Apis mellifera L.) and earthworm (Eisenia fetida). The EC50 value, toxicological responses of thyme white, clove bud, and cassia to Daphina magna were 2.5, 2.8, and 6.9 mg L<SUP>-1</SUP> respectively and these values were moderately toxic according to standard of USEPA. EC<SUB>50</SUB> of Lavender and lemon eucalyptus were >10 mg L<SUP>-1</SUP> then they were considered as slightly toxicity. In case of acute toxicity test to fish, LC<SUB>50</SUB> of thyme white and cassia were 6.7 and 7.5 mg L<SUP>-1</SUP> each other. The other plant essential oils indicated LC<SUB>50</SUB> >10 mg L<SUP>-1</SUP>. Acute contact and oral toxicity test to Honeybee were conducted. As a result, LD<SUB>50</SUB> of all essential oils were >100 ㎍ a.i. bee<SUP>-1</SUP> in both of tests. In case of acute toxicity test to earthworm, LC<SUB>50</SUB> of thyme white, clove bud, cassia, lavender, and lemon eucalyptus were 149,230, 743, 234, and 635 mg kg<SUP>-1</SUP>, respectively. In conclusion, if the safety for earthworm is confirmed, 5 plant essential oils are expected to be use for environment-friendly insecticide materials with low risk against ecosystem and contribute to developing environment-friendly agro-materials.
내분비장애물질로서 Metribuzin의 랫드와 HeLaTRE Cell 중 갑상선 호르몬활성 영향
유아선(Are-Sun You),정미혜(Mihye Jeong),이제봉(Je Bong Lee),박연기(Yoen-Ki Park),신진섭(Jin Sup Shin),박경훈(Kyung-Hun Park) 한국농약과학회 2008 농약과학회지 Vol.12 No.4
This study was carried out to investigate the suitability of the pubertal assay and the enhanced TG 407 as methods for detection of endocrine-mediated effects. Thyroid function was also considered, Male and female Sprague-Dawley rats were gavaged daily with 0, 25, 50, 100 ㎎/㎏ metribuzin in corn oil during 30 days. The effects of metribuzin on thyroid gland, the genital organs and thyroid hormone were measured in male and female rats. Dose of metribuzin 50 ㎎/㎏/day increased relative weight of testis, prostate, and seminal vesicle in male rats but relative weight of thyroid gland was not significantly different fi'om control group. Dose of metribuzin 25 ㎎/㎏/day decreased relative weight of thyroid gland in female rats. Another purpose of this study was to investigate the effects of endocrine-disruptors as like thyroid hormone in vitro. Luciferase activity was measured to detect reaction of test chemicals and thyroid hormone response elements in HeLaTRE cell. Dose of metribuzin from 1 to 1,000 nM increased to 106-122% of luciferase activity.