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당뇨병환자에서 동맥경화증의 병인에 관여하는 내피세포 및 혈소판의 기능에 관한 연구
우종욱(Chong Wook Woo),김현수(Hyun Soo Kim),홍대식(Dae Sik Hong),박희숙(Hee Sook Park),유명희(Myung Hi Yoo),김극배(Guk Bae Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.1
N/A Atherosclerosis is well known as a major complication in diabetes. To investigate the role of platelet function, Factor VIII: vWF and prostacyclin in the pathogenesis of atherosclerosis in diabetes, we performed a platelet function test and measured PGF 1 which is a metabolite of prostacylin, Factor VIII: vWF and thromboxande B2 in 15 patients with diabetes and 10 normal controls. The platelet function test showed that ADP-induced platelet aggregation was significantly enhanced in diabetic patients with retinopathy (80.6±11. 45% vs 42.6±8.71%, p<0.05) compared with normal controls, but collagen induced platelet aggregation or platelet adhesiveness showed no significant difference between diabetic patients and normal controls. The plasma Factor VIII R: Ag level in diabetic patients as not signficantly different from normal controls while plasma Factor VIII: vWF in diabetic patients was significantly increased compared with normal controls (51.33±5.33% vs 27.50±6.71%, p<0.05) The prostaglandin F1α level was signficantly decrease in diabetic patients (2.01±0.32 pg/tube vs 3. 17±0.48pg/tube, p<0.05), while the plasma thromboxane B2 level showed no signficant difference between diabetic patients and normal controls. Our data showed that the increase plasma Factor VIII: vWF level and decrease PGF1α level as well as abnormal platelet function may contribute to the mechanism of atherosclerosis in diabetic patients.
김명환(Myung Hwan Kim),김선주(Sun Joo Kim),우종욱(Chong Wook Woo),정재삼(Jae Sam Jung),조무식(Moo Sik Cho) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.2
N/A Enteritis necroticans, or pig-bel, a rare type of food poisoning seen primarily in Papua New Guinea, is probably caused by clostridium welchii type C producing beta toxin. The appearance of small intestine, and in particular the jejunum, was consistent with gangrenous enteritis of patchy distribu- tion. We report a case of necrotizing jejunitis probably caused by ingestion of infected food.
자동차제조회사 근로자 1865명에 대한 위내시경적 집단검진 소견
최인영,우종욱,안영락 대한소화기내시경학회 1993 Clinical Endoscopy Vol.13 No.2
Background: Stomach cancer is the most commonly diagnosed malignant tumor in Korea. Early detection by mass screening very important to increase survival rate of stomach cancer, because the prognosis of early gastric cancer is excellent, and specific symptoms and physical findings are rare with early gastric cancer. Methed: 1865 car manufacturing company employees were examinined by gastrofiberscopy at a dispensary of the company from May 6, l992 to July 13, 1992. Results: 1. Number of cases with normal finding was 1262(67.7%), gastritis 422(22.6%), gastric ulcer 47(2.5%), gasrtric cancer 4(0.2%), duodenitis 39(2.1%), duodenal ulcer 63(3.4%), combined ulcer(gastric & duodenal) 2(0.1%,), post operative state 6(0.3%), and others 4(0.3%) in total 1865 examinees. 2. Of 422 cases with gastritis, cases with superficial gastritis were 171 (9.2%), atrophic gastritis 138(7.4%), erosive gastritis 94(5.0%) and hemorrhagic gastritis 19(1.0%). 3. Of 4 cases with stomach cancer, 1 case was advanced stomach cancer and 3 cases were early gastric cancer(two cases of IIc and one case of IIc+III) by macroscopic classification. Conclusion: Mass screening provides an excellent opportunity to detect gastric cancer in populations without symytoms or with nonspecific symptoms. It should be recommended to undergo screening exam for high risk group of stomach cancer.
중증감염후 일시적인 자연관해를 보인 성인 급성백혈병 1예
임상복,황효주,우종욱,홍대식,박희숙,김원배 대한내과학회 1990 대한내과학회지 Vol.38 No.3
Spontaneous remission of acute leukemia, first described by Eisenlohr in 1878, is very rare but well-documented in the literature. Spontaneous remission in these cases was a associated with systemic infections, even though in some instances transfusion of blood products and termination of pregnancy were also implicated. Recently, we observed a spontaneous complete remission of 18 weeks duration in a 24-year-old female with acute lymphocytic leukemia. The remission occurred after pneumonia and a skin infection on the extremities.