http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 오재룡(Jae-Ryong Oh) (검색결과 8 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
-
-
유기주석화합물이 명주조개 (Coelomactra antiquata)의 약물대사효소계에 미치는 영향
전중균,이미희,김도진,심원준,오재룡,이수형,Jeon Joong Kyun,Lee Mee Hee,Kim Do Jin,Shim Won Joon,Oh Jae Ryong,Lee Soo Hyung 한국수산과학회 2002 한국수산과학회지 Vol.35 No.2
강원 북부연안에 많이 서식하는 명주조개 (C. antiquafa)를 대상으로 중장선의 미크로좀을 in vitro로 유기주석화합물 (TBTO, TBTC, TPTC)과 배양하여 약물대사효소계의 cytochrome P450 (CYP)과 7-ethoxyresorufin-O-deethylase (EROD)의 변화를 조사하였다. 그 결과, 이들 화합물은 모두 명주조개의 약물대사효소계를 짧은 시간 내에 저해한다는 것을 확인하였다. 즉,미크로좀을 0.4 mM 농도의 TBTC, TBTO 및 TPTC와 20분간 배양한 후의 CYP 함량은 첨가하기 전에 비해 각각 $52\%$, $72\%$ 및 $40\%$로 줄었는데, 이것으로 화합물의 종류에 따라서 저해 정도는 차이가 있었고 butyltin화합물보다는 phenyltin화합물의 저해 정도가 더 컸다. 그리고 EROD 활성의 경우도 0.4 mM의 TBTC, TBTO 및 TPTC와 20분 간 배양하였더니 각각 $100\%$, $92\%$ 및 $85\%$로 butyltin 화합물보다 는 phenyltin 화합물의 저해가 더 컸다. 한편, TBTC, TBTO 및 TPTC 모두는 패류 중장선의 CYP와 EROD 활성을 농도의존적으로 저해하였으며, 그리고 두 효소는 모두 오염물질에 노출된 패류의 좋은 생체지표 (bioindicator)로 활용할 수 있을 것이라 여겨진다. This study was carried out to measure the in vitro interaction of trialkyltin with the microsomal monooxygenase (MFO) system of the clam, Coelomactra antiquata. Cytochrome P450 (CYP) level and 7-ethonvesorufin-O-deethylase (EROD) activity were invetigated in the microsome isolated from digestive gland of the clam (C. antiquata) exposed to tributyltin chloride (TBTC), bis-tributyltinoxide (TBTO) and triphenyltin chloride (TPTC). The specific contents of CYP in clam microsome exposedto 0.4 mM TBTC, TBTO and TPTC for 20 minutes were decreased 52, 72 and $40\%$, respectively, compared to control group. The EROD activities also were inhibited by exposure to TBTO ($92\%$) and TPTC ($85\%$) except for TBTC, The level of CYP and the EROD actintles were decreased according to the OTC exposure concentrations. The toxic effects on the level of CYP and the EROD activities were in order of TPTC>TBTC>TBTO in this study. The measurement of CYP level and EROD activity could be applied as a biomarker for environmental study.
-
-
조현서(Hyeon-Seo Cho),김동명(Dong-Myong Kim),최희구(Hee-Gu Choi),오재룡(Jae-Ryong Oh) 한국해양환경·에너지학회 2004 한국해양환경공학회 학술대회논문집 Vol.2004 No.-
It is very important to know the fate of a chemical in the regional or universal environment to control the hazardous chemicals. The fate modelling is the most effective method to predict the concentrations in ecosystem. It is possible to find the most effective policy to control the chemicals harmful to ecosystem including human being to apply the several management scenarios simulated by the fate model. The method is very useful to make a decision making. Organotin compounds are widely used as antifouling paint to prevent adherence of sedentary organisms to ship hull and other structural surfaces immersed in seawater. Organotins such as tributyltin(TBT) and triphenyltin(TPT) are considered to be dangerous chemicals because of their deleterious effects on non-target marine organisms. In this study, the fate of tributyltin(TBT) compounds was simulated by using basin-wide ecological model(BAWEM) coupled with the three-dimensional eco-hydrodynamic model to predict the concentrations of TBT compounds in multi-medias such as water, sediment, organisms in JInhae Bay, Korea, The model was calibrated with the data surveyed in the study area. The computed tidal currents at two levels obtained by M2 tide on a three-dimensional hydrodynamic model were in good agreement with the observed currents. The simulated results of TBT compound were fairly good coincided with the observed values within the same order. For the control of TBT compound, the risk assessment and management based on the recent toxicological data, the exposure levels in ecosystem and the alternative scenarios should be performed.
-
KCI
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
