http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
외인성 내분비계장애물질에 노출된 랫드 전립샘과 정낭샘에서 Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx) mRNA의 발현양상
연정민(Jung-Min Yon),백인정(In-Jeoung Baek),유욱준(Wook-Jun Yoo),이범준(Beom-Jun Lee),윤영원(Young Won Yun),남상윤(Sang-Yoon Nam) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
외인성 에스트로젠화합물(내분비계장애물질)은 생체에 있어서 극미량으로 작용하기에, 지금까지 포유류를 포함한 각종 동물에 미치는 위해성을 직접적으로 평가할 수 있는 연구결과는 매우 부족한 실정이다 PHGPx는 셀레늄을 포함하는 항산화효소로서, 최근에 PHGPx mRNA가 외인성 estradiol 투여에 의해 고환에서 증가하는 것을 확인한 바 있다. 본 연구에서는 새로운 biomarker로서 PHGPx를 활용하여 랫드의 전립샘과 정낭샘에서 내분비계장애물질의 위해성을 분자수준에서 조사하였다. 4주령의 수컷랫드에 NP(10-250 ㎎/㎏), OP(10-250 ㎎/㎏), Flu(1-25 ㎎/㎏), DES(10-40 ㎍/㎏), KC(0.2-1 ㎎/㎏), Tes(50-1000 ㎍/㎏), 및 DEHP(10-250 ㎎/㎏)을 3주간 매일 구강으로 투여한 후, 전립샘과 정낭샘을 분리하여 PHGPx mRNA 발현에 대한 RT-PCR분석을 실시하였다. 전립샘과 정낭샘에서 PHGPx 발현은 NP, OP, DES, KC, 및 DEHP와 같은 항안드로젠성 또는 에스트로젠성 화합물의 투여에 의해서 영향을 받았지만, Flu와 함께 Tes와 같은 안드로젠성 물질에 의해서는 큰 변화가 없었다. 따라서, PHGPx는 전립샘과 정낭샘에 있어서 극미량으로 작용하는 환경성 에스트로젠화합물의 위해성을 평가하는 데 있어서 매우 유용한 biomarker로서 활용가능하리라 사료된다. The purpose of this study was to investigate the expression pattern of PHGPx gene in the prostates and seminal vesicles exposed to various environmental endocrine disruptors. Male Sprague-Dawley rats (4 weeks old) were orally treated with nonylphenol (NP; 10-250 ㎎/㎏), octylphenol (OP; 10-250 ㎎/㎏), flutamide (Flu; 1-25 ㎎/㎏), diethyIstilbesterol (DES; 10-40 ㎍/㎏), ketoconazole (KC; 0.2-1 ㎎/㎏), testosterone (Tes; 50-1,000 ㎍/㎏), diethylhexyl phthalate (DEHP; 10-250 ㎎/㎏) for 3 weeks daily and then total RNAs were extracted from the prostates and seminal vesicles for RT-PCR analysis. In both organs, PHGPx mRNA level was changed by NP, OP, DES, KC, DEHP and DES treatments, while it was not changed by Flu and Tes administrations. These results indicate that estrogenic or antiandrogenic endocrine disruptors may affect the cellular micro-environments of prostates and seminal vesicles and PHGPx is an useful biomarker for the screening of environmental endocrine disruptors in male accessary reproductive organs.
돼지감자 추출액이 Streptozotocin으로 유발된 당뇨쥐에서 혈당 및 지질대사에 미치는 효과
김혜정 ( Hye Jeong Kim ),김동일 ( Dong Il Kim ),연정민 ( Jung Min Yon ) 대한임상검사과학회 2015 대한임상검사과학회지(KJCLS) Vol.47 No.4
This study investigated the effect of Jerusalem artichoke (Helianthus tuberosus L.) extract on Blood Glucose and Lipid Metabolism in Streptozotocin (70 mg/kg B.W., i.p.)-induced Diabetic Rats. Sprague-Dawley male rats (200∼220 g) were divided into normal control group (NC), diabetic control group (DC) and Jerusalem artichoke treated diabetic group (DJ). Diabetes was induced by single intraperitoneal injection of streptozotocin as a dose of 70 mg/kg body weight. Food (p<0.001) and water (p<0.05) intakes were higher in diabetic groups than the normal group. Body weight gain and food efficiency ratio were significantly lower in diabetic groups than normal group (p<0.01). However, they were higher in the DJ group than in the DC group. The serum levels of AST and ALT were significantly lower in the DJ group than in the DC group (p<0.05). The serum level of HDL-C was significantly higher in the DJ group than in the DC group (p<0.001). The serum levels of Triglyceride (p<0.05), LDL-C (p<0.001), and glucose (p<0.001) were significantly lower in the DJ group than in the DC group. At 3 and 4 weeks after the experiment, blood glucose level in the DJ group was significantly lower than the DC group (p<0.05). In conclusion, these results indicated that Jerusalem artichoke can prevent or retard the development of diabetic complications via its beneficial effects for alleviating the hyperglycemia and improved lipid metabolism.
신선희(Sunhee Shin),장자영(Ja Young Jang),백인정(In-Jeoung Baek),연정민(Jung-Min Yon),남상윤(Sang-Yoon Nam),윤영원(Young Won Yun),조대현(Dae-Hyun Cho),김순선(Soon-Sun Kim),이규식(Gyu-Seek Rhee),곽승준(Seung-Jun Kwack),김윤배(Yun-Bae 한국독성학회 2005 Toxicological Research Vol.21 No.4
The developmental toxicity of water extract of licorice (Glycyrrhiza glabra) was evaluated in rats. Licorice extract (500, 1,000 or 2,000 ㎎/㎏) was dissolved in drinking water and orally administered to male rats from 9 weeks before mating to the day of copulation, and to females from 2 weeks before mating to gestational day 19. On gestational day 20, the animals were sacrificed for Cesarian section, and maternal and fetal abnormalities were examined. Licorice extract neither induce clinical signs, nor affect the body weight gain, feed and water intake, estrous cycle, copulation and fertility rates, blood 17β-estradiol level and organ weights of dams. Also, the implantation and development including body weights, absorption and death of embryos and fetuses were not influenced by in utero exposure to licorice. In addition, there were no increases in external, visceral and skeletal abnormalities of fetuses. Taken together, it is suggested that no observed adverse effect level of licorice extract is higher than 2,000 ㎎/㎏, and that long-term in utero exposure to licorice might not cause developmental toxicities of embryos and fetuses.
C57BL6 마우스에서 복합생약제인 황금궁의 육모 효과
허진주(Jin Joo Hue),리란(Lan Li),유설혜(Sul Hye Lyu),백인정(In Jeoung Baek),연정민(Jung Min Yon),남상윤(Sang Yoon Nam),윤영원(Young Won Yun),황석연(Seock Yeon Hwang),홍진태(Jin Tae Hong),이범준(Beom Jun Lee) 대한약학회 2005 약학회지 Vol.49 No.6
Hwanggumgung (HGG) is a hair-care product which is composed of several plant extracts used in oriental medicine. This study was carried out to investigate effect of HGG on hair regrowth in a shaving model of C57BL6 mice. Five-week-old mice were acclimated for 1 week under 23±3℃, 50±10% relative humidity, and 12h of a light/dark cycle before beginning experiment. There were four experimental groups including distilled water (D.W., control), 10% ethanol (EtOH, vehicle control), a positive control of 3% minoxidil (MXD), and HGG for female and male mice, respectively. Six-weeks old mice were trimmed by electric clippers so as not to damage the skin. The next day, mice without visible scraches were selected, randomized and separated in groups of 11 mice. The test compounds were topically treated with 0.15㎖ per mouse per day for 21 days. The hair regrowth was photographically and histologically determined during the experimental period of 21 days. Enzyme activities of γ-glutamyl transpeptidase and alkaline phosphatase were also determined using a rate assay method. There were no clinical signs in all experimental groups. The topical application of 3% MXD and HGG in female mice promoted hair regrowth earlier and faster than the control groups. In male mice, the topical application of 3% MXD and HGG also accelerated hair growth compared with the controls. Ten percent ethanol also promoted hair growth faster than D.W group. The histology of hair growth in experimental groups was strongly associated with the hair regrowth. 3% MXD and HGG promoted elongation of hair follicles compared with the controls in both female and male mice. Activities of alkaline phosphatase and γ-glutamyl transpeptidase, enzymes related to hair growth, significantly increased after treatments of 3% MXD and HGG for 2 weeks in both female and male mice (p<0.05). These results suggest that HGG has hair growth promoting activities and it can be for treatment for alopecia.
C57BL/6 마우스 모델에서 NDM 발모제의 모발성장 촉진 효과
남상윤(Sang Yoon Nam),문준환(Jun-Hwan Mun),윤영원(Young Won Yun),백인정(In Jeoung Baek),연정민(Jung Min Yon),김영철(Young Chul Kim),류광철(Kwang Chuel Ryu),이범준(Beom Jun Lee) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
NDM hair tonic is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate effect of NDM hair tonic on hair growth in an alopecia model of C57BL/6 mice. Hair of six-weeks old mice were removed by topical treatment of Neclean<SUP>Ⓡ</SUP>, The next day, animals were randomized and separated in groups of 6 mice. There were four experimental groups including saline (negative control), 50% ethanol (vehicle control), 3% minoxidil (MXD), and NDM tonic. The test compounds were topically treated with 0.15 ㎖ per mouse per day for 2 weeks. The hair regrowth was determined photographically and histologically and the quantity of endocrine factors, IGF-1 and TGF-β, in the skin of mice using PCR was measured. No clinical signs were found in all animals. The topical treatment of NDM tonic or MXD for 2 weeks to dorsal skin accelerated hair regrowth faster than the controls. The NDM tonic or MXD treatment also promoted hair follicle elongation compared to the controls. The NDM tonic or MXD treatment significantly increased the expression of IGF-1 in the skin of C57BL/6 mice compared to the control (p<0.05). These results suggest that NDM-tonic has hair growth promoting activities and it can be useful for treatment for baldness or alopecia.
C57BL/6 마우스에서 기능성 샴푸 Bonogen의 양모 촉진 효과
홍진태(Jin-Tae Hong),이세라(Se-Ra Lee),김환희(Hwan Hee Kim),조영광(Young-Kwang Jo),백인정(In-Jeoung Baek),연정민(Jung-Min Yon),남상섭(Sang-Seop Nahm),곽동훈(Dong Hoon Kwack),이정은(Jung Eun Lee),이범준(Beom-Jun Lee),윤영원(Young-Won 한국독성학회 2006 Toxicological Research Vol.22 No.3
Bonogen shampoo is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate the effects of Bonogen shampoo on hair growth in an alopecia model of C57BL/6 mice. There were eight male and female experimental groups including distilled water (DW; negative control), a commercial shampoo [M], 3% minoxidil (MXD) and Bonogen shampoo (BNG). Dorsal skin hair of six-week-old mice was trimmed with an electric clipper carefully not to damage the skin. The next day, mice without skin scratch were selected, randomized and separated in 10 mice per group. The test compounds were topically treated with 0.15 ml per mouse on dorsal skin for 21 days daily and then washed thoroughly with DW. The hair regrowth was determined photographically at 0, 4, 7, 10, 15, 18, and 21 days and histologically at day 21. No clinical signs were observed in all mice. Although body weight was slightly increased in 3% MXD group than other groups, it was not significant. Hair regrowth began to be promoted after 14 days and appeared a distinct regrowth pattern in all animals by topical treatment of test compounds at 18 days. In particular, the topical treatment of bonogen shampoo or 3% MXD for 21 days to dorsal skin accelerated hair regrowth faster than DW or M shampoo. At 21 days, the hair regrowth promotion speed was in order of 3% MXD > BNG > M > DW. The bonogen shampoo or 3% MXD also promoted hair follicle elongation compared to the negative control. These results suggest that bonogen shampoo has hair growth promoting activities and may be useful for treatment of bald or alopecia.