Single Positive Core Prostate Cancer in a 12-Core Transrectal Biopsy Scheme: Clinicopathological Implications Compared with Multifocal Counterpart

안홍재,고영휘,장훈아,강성구,강석호,박홍석,이정구,김제종,천준 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.10

Purpose: The incidence of single positive core prostate cancer at the time of biopsy appears to be increasing in the prostate-specific antigen (PSA) era. To determine the clinical implication of this disease, we analyzed surgical and pathological characteristics in comparison with multiple positive core disease. Materials and Methods: Among 108 consecutive patients who underwent robotic radical prostatectomy following a diagnosis of prostate cancer based on a 12-core transrectal biopsy performed by the same method in a single institute, outcomes from 26 patients (Group 1) diagnosed on the basis of a single positive biopsy core and from 82 patients (Group 2) with multiple positive biopsy cores were analyzed. Results: The preoperative PSA value, Gleason score, prostate volume, and D’Amico’s risk classification of each group were similar. The proportion of intermediate+high- risk patients was 69.2% in Group 1 and 77.9% in Group 2 (p=0.22). Total operative time and blood loss were similar. Based on prostatectomy specimens, only 3 patients (11.5%) in Group 1 met the criteria for an indolent tumor (7.31% in Group 2). Although similarities were observed during preoperative clinical staging (p=0.13), the final pathologic stage was significantly higher in Group 2 (p=0.001). The positive-margin rate was also higher in Group 2 (11.5% vs. 31.7%, p=0.043). Despite similarity in upstaging after prostatectomy in each group (p=0.86), upgrading occurred more frequently in Group 1 (p=0.014, 42.5% vs. 19.5%). No clinical parameters were valuable in predicting upgrading. Conclusions: Most single positive core prostate cancer diagnoses in 12-core biopsy were clinically significant with similar risk stratification to multiple positive core prostate cancers. Although the positive-margin rate was lower than in multiple positive core disease, an increase in Gleason score after radical prostatectomy occurred more frequently.

국내 도시첨단산업단지 입주 선호요인 분석

안홍재,고석찬 한국국정관리학회 2018 현대사회와 행정 Vol.28 No.4

본 연구의 목적은 국내 기업들이 도시첨단산업단지 입주 시 어떤 요인을 선호하는지를 규명하고, 이를 통해 향후 국내 도시첨단산업단지 조성 및 운영 활성화와 제도 개선에 필요한 정책적 시사점을 제공하는 데 있다. 이를 위해 본 연구에서는 도시첨단산업단지 입주기업 또는 향후 입주 가능성이 높은 수도권 서남부 지역의 첨단 지식기반기업들을 대상으로 설문조사를 통하여 선호하는 입지요인을 분석하고 구체적인 지원정책을 조사하였다. 설문조사 자료를 분석한 결과, 선호하는 입주요인으로는 향후 단지의 발전가능성, 생활기반 시설, 교통의 편리성, 분양임대 가격 등의 요인이 긍정적인 영향을 미치는 것으로 나타났다. 이러한 요인들이 갖추어질수록 도시첨단산업단지의 경쟁우위는 강화되는 것으로 판단된다. 우선적으로 필요한 정책지원 분야를 조사한 결과, 기업체에게 필요한 정책적 인센티브는 저렴한 임대 공간 제공과 지방세 감면, 분양대금 장기분할납부 및 저리융자 등인 것으로 나타났다. 또한 단지 내에 필요한 조성 및 유치시설에 관하여는 벤처기술인력 양성센터와 스타트업 센터 등을 선호하고 있는 것으로 조사되어 도시첨단산업단지 활성화를 위한 관련 시사점을 제시한다. The primary purpose of this paper is to investigate the factors affecting firms’ preference of Urban High-Tech Industrial Complexes(UHTIC) which have been developed in major Korean cities since 2001. By analyzing the data gathered through the field survey of high-tech firms in the southwestern area of Seoul Metropolitan Region, the research finds that the tenant firms as well as potential tenants tend to prefer the existence of ‘training institutions for skilled workforce’ and ‘start-up centers for innovative Small & Medium Enterprises’ when they set-up and relocate their facilities in UHTICs. This research findings shed light on the insight for industrial strategy to make UHTICs more attractive and viable. First, the programs for incubation and acceleration services need to be provided to high-tech start-ups in an early stage of their life cycle. Second, work life balanced infrastructures should be necessary to attract highly skilled workforce for high-tech companies located in UHTICs.

기술창업기업의 입지환경 특성이 경영성과에 미치는 영향

안홍재(Ahn, Hong-Jae),고석찬(Ko, Suk-Chan) 한국지역개발학회 2019 韓國地域開發學會誌 Vol.31 No.2

The primary aim of this thesis is to provide the implication in terms of location environmental characteristics to invigorate New Technology-Based Firm(NTBF) which has been globally regarded as a crucial tool for local economic development as well as job creation. To accomplish the purpose of this research, the thesis examines whether Location Characteristics(LC) of NTBFs have an influence on their Management Performance(MP). By analyzing the data gathered through the field survey of the tenant firms in the 2nd Pangyo Techno Valley which is being developed as an innovative start-up ecosystem, the research finds that the industrial cluster factor affects positively on MP of NTBFs. Both economic factor and supporting facility factor also have positive moderating effects on the relationship between LC and MP. However, accessibility factor shows a negative moderating impact on the relationship between LC and MP. These findings suggest that the stimulation and facilitation of NTBFs require appropriate enhancement of all of the location environmental characteristics as mentioned above. Furthermore, the result of this research can provide useful lessons for the development of the 2nd Pangyo Techno Valley as an innovative cluster for NTBFs in Korea.

Clinical Implications of Residual Urine in Korean Benign Prostatic Hyperplasia (BPH) Patients: A Prognostic Factor for BPH-Related Clinical Events

고영휘,채지윤,정승민,강재일,안홍재,Hyung Woo Kim,강성구,장훈아,천준,김제종,이정구 대한배뇨장애요실금학회 2010 International Neurourology Journal Vol.14 No.4

Purpose: Although post-void residual urine (PVR) is frequently utilized clinically in patients with benign prostatic hyperplasia (BPH), mainly because of its procedural simplicity, its role as a clinical prognostic factor, predictive of treatment goals, is still under much dispute. We investigated the predictive value of PVR for BPH-related clinical events including surgery, acute urinary retention (AUR), and admission following urinary tract infection (UTI). Methods: From January to June of 2006, patients over 50 years of age who were diagnosed with BPH for the first time at the outpatient clinic and were then treated for at least 3 years with medications were enrolled in this study. The variables of patients who underwent surgical intervention for BPH, had occurrences of AUR, or required admission due to UTI (Group 1, n=43) were compared with those of patients who were maintained with medications only (Group 2, n=266). Results: Group 1 had a significantly higher PVR, more severe symptoms, and a larger prostate at the time of the initial diagnosis in both the univariate and the multivariate analysis. In the 39 patients who underwent BPH-related surgery, although there was a significant change in Qmax at the time of surgery (mean, 13.1 months), PVR and the symptom score remained unchanged compared with the initial evaluation. In the receiver-operating characteristic curve analysis, the area under the curve of Group 1 was in the order of prostate volume (0.834), PVR (0.712), and symptom score (0.621). When redivided by arbitrarily selected PVR cutoffs of 50 mL, 100 mL, and 150 mL, the relative risk of clinical BPH progression was measured as 3.93, 2.61, and 2.11. Conclusions: These data indicate that, in the symptomatic Korean population, increased PVR at baseline is a significant indicator of BPH-related clinical events along with increased symptom score or prostate volume.

Robot-Assisted Laparoscopic Distal Ureterectomy and Ureteral Reimplantation

강성구,최훈,고영휘,태범식,조석,안홍재,채지윤,강석호,천준 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.9

We report here on our technique and outcomes of the first case of robot-assisted laparoscopic distal ureterectomy with a bladder cuff excision and ureteroneocystostomy. A 74-year-old male patient who had a distal ureter tumor underwent robot-assisted transperitoneal distal ureterectomy. After distal ureterectomy with bladder cuff excision was performed, direct ureteroneocystostomy was performed. The whole procedure was successfully performed by using the robot without conversion to open surgery. The total operative time was 207 minutes, and the estimated blood loss was 30 ml. The final pathological examination showed stage T2 invasive transitional cell carcinoma of the distal ureter. The patient's postoperative recovery was uneventful and the bladder cuff was free of tumor. Robot-assisted laparoscopic distal ureterectomy with ureteroneocystostomy is safe and feasible and offers patients the advantages of minimally invasive surgery.