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Gabapentin for the Treatment of Chronic Pelvic Pain Syndrome in Patients with High Pain Score
조석,In-Rae Cho 대한요로생식기감염학회 2019 Urogenital Tract Infection Vol.14 No.2
Purpose: The underlying pathogenic mechanisms of chronic pelvic pain syndrome (CPPS) are unclear. A growing body of evidence suggests that the urogenital pain of CPPS may be neuropathic in origin. The objective of this study was to determine if gabapentin can be an effective treatment for the symptoms of CPPS with severe pain.Materials and Methods: Thirty five males with CPPS (category IIIa 25, IIIb 10) and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total pain score ≥9 in the previous six months were enrolled in this study between October 2010 and December 2011. The dosage of gabapentin was increased from 300 mg/d to 600 mg/d during the first four weeks. The primary outcome was evaluated as an improvement in the NIH-CPSI from the baseline to week eight.Results: This study examined 35 males with CPPS and a mean age of 54.2±9.8 years, mean disease duration of 34.2±27.7 months, and a mean prostate volume of 24.9±5.3 ml. The decrease in the total NIH-CPSI pain domain at four weeks was significant with no change observed after eight weeks. Between the category IIIa and IIIb CPPS patients, the change in the total pain domain was not significant.Conclusions: Gabapentin may be effective in some males with CPPS who have a high pain score. More gabapentin may be useless and possibly harmful if gabapentin does not decrease the pain at four weeks.
조석,박현식,최기용,강경호,백원필,김연식 한국원자력학회 2009 Nuclear Engineering and Technology Vol.41 No.10
Several experimental tests to simulate a reflood phase of a cold-leg LBLOCA of the APR1400 have been performed using the ATLAS facility. This paper describes the related experimental results with respect to the thermal-hydraulic behavior in the core and the system-core interactions during the reflood phase of the cold-leg LBLOCA conditions. The present descriptions will be focused on the LB-CL-09, LB-CL-11, LB-CL-14, and LB-CL-15 tests performed using the ATLAS. The LB-CL-09 is an integral effect test with conservative boundary condition; the LB-CL-11 and -14 are integral effect tests with realistic boundary conditions, and the LB-CL-15 is a separated effect test. The objectives of these tests are to investigate the thermal-hydraulic behavior during an entire reflood phase and to provide reliable experimental data for validating the LBLOCA analysis methodology for the APR1400. The initial and boundary conditions were obtained by applying scaling ratios to the MARS simulation results for the LBLOCA scenario of the APR1400. The ECC water flow rate from the safety injection tanks and the decay heat were simulated from the start of the reflood phase. The simulated core power was controlled to be 1.2 times that of the ANS-73 decay heat curve for LB-CL-09 and 1.02 times that of the ANS-79 decay curve for LB-CL-11, -14, and -15. The simulated ECC water flow rate from the high pressure safety injection pump was 0.32 kg/s. The present experimental data showed that the cladding temperature behavior is closely related to the collapsed water level in the core and the downcomer.
Poly(Methacryloyl-D-Glucosamine) (poly(MANGlc)) Prodrugs의 합성 및 항암활성
조석형 혜전대학 1997 論文集 Vol.15 No.-
5-FU-1-acetic, Glc-5-FU, MANGlc 등의 유도체를 합성하였고(MANGF-co-MANG)(Ⅳ), poly(MANGF-coMAA)(Ⅴ) 등의 poly(MANGF-co-AAm)(Ⅵ), poly(MAOGF-co-MAA)(Ⅶ) 등의 수용성 polymer prodrug을 합성하였다. polymer prodrug의 항암활성은 Sarcoma-180 담암 마우스에 대하여 복강 투여함으로써 in vivo 실험을 행하였으며 이들 poly-merprodrug과 monomer prodrug들은 약리활성의 지속성을 증대시키고 5-FU의 독성을 감소시킴으로서 비교적 높은 생체 적합성과 좋은 항암활성을 나타내었다. Derivatives such as 5-FU-1-acetic acid, Glc-5-FU, and MANGlc containing D-glucosamine as a spacer were synthesized. And Water-soluble polymer prodrug such as poly(MANFG-co-MANG)(Ⅳ), Poly(MANFG-co-MAA)(Ⅴ), poly(MANFG-co-AAm)(Ⅶ) were synthesized. The antitumor activity was tested against Sarcoma-180 ascites in female mice in vivo by intraperitoneal injection of the polymer prodrugs. These polymer prodrugs and monomer prodrugs showed relatively high biocompatibility and good antitumor activity by increasing the drravility of drug activity and reducing the toxicity of 5-FU.