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단일 기관에서 소아 굴곡성 기관지내시경에 대한 임상 경험
안혜성 ( Hye Sung Ahn ),최은정 ( Eun Jeong Choi ),윤현진 ( Hyun Jin Yun ),왕승문 ( Sheng Wen Wang ),권은영 ( Eun Young Kwon ),황규근 ( Kuy Geun Hwang ),이영석 ( Young Seok Lee ),정진아 ( Jin A Jung ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.3
Purpose: This study was performed to investigate the indications, bronchoscopic findings, results of bronchoalveolar lavage, and complications and to report the clinical features of using flexible bronchoscopy for respiratory diseases in children. Methods: We studied 105 patients who underwent flexible bronchoscopy at the Department of Pediatrics, Dong-A University Medical Center from June 2001 to June 2008. A bronchoalveolar lavage (BAL) was performed if need, and the BAL fluid was cultured for bacteria and fungi. We performed an acid-fast bacilli (AFB) smear and culture. Result: The most common indication for flexible bronchoscopy was suspected pulmonary tuberculosis (37 cases, 35.2%). The most common abnormal finding was excessive secretion, which was found in 53 cases (50.4%). BAL bacterial cultures were performed in 10 of 38 cases, and Hemophilus influenza was the most common organism and was found in three cases (7.8%). There were 17 AFB culture-positive cases (49.3%) among the 37 suspected pulmonary tuberculosis cases. Among these 17, the Tb-polymerase chain reaction (Tb-PCR) was conducted for four cases (23.5%) but only two cases (50%) were positive. TB-specific antigen-induced interferon-gamma was performed in four cases (23.5%), and all four cases (100%) were positive. Conclusion: Pediatric flexible bronchoscopy has made it possible to vary the indication and subjects. It was also safe and effective if used carefully. Further study should be conducted to develop safe and useful technology to overcome the limitations. [Pediatr Allergy Respir Dis(Korea) 2011;21:226-233]
안혜성(Hye Sung An),김종민(Jong-Min Kim),황규근(Kyu Geun Hwang) 대한소아신경학회 2013 대한소아신경학회지 Vol.21 No.4
목 적:비스페놀 A (BPA)는 가소제로 광범위하게 사용되고 있는 물질로서, 생체 노출 시 여러 가지 악영향이 보고되어 있다. BPA는 아주 낮은 농도로도 그 위해작용 효과가 크고 에스트로겐 성질을 갖고 있는 내분비계장애물질로 분류되고 있다. BPA는 인체의 혈액, 소변, 양수 및 태반에서 일정량 검출되고 있다. 현재까지 BPA 노출에 의한 신경계에 대한 영향연구는 매우 부족한 상태이다. 본 연구에서는 BPA가 임신 중인 흰쥐 모체에 노출되었을 경우, 후세대 소아기 뇌발생과정 중 뇌세포의 증식과 분화상 어떠한 변화를 야기하는지 조사하고자 하였다. 방 법: BPA 노출은 저농도(0.01 mg/kg/일)와 고농도(1 mg/kg/일) 처리군 2가지로 하였고, 생후 3, 7 및 14일째에 각각의 신생흰쥐로부터 대뇌조직을 적출하여 조직학 및 생화학적 분석을 수행하였다. 결 과:일반 조직염색과 PCNA 면역염색 결과, 정상 대조군의 경우, 생후 3일째와 7일째 뇌조직은 주로 세포증식이 활발한 신경상피세포로 구성되어 있는 것으로 추정되었고, 생후 14일째에는 세포증식도가 낮고 형태학적으로 핵이 크고 세포질이 뚜렷이 관찰되는 신경세포가 분화하는 것으로 보였다. 그리고 GFAP 면역반응 양성을 나타내는 세포는 생후 7일째부터 관찰되었다. 그러나 BPA 노출군은 생후 3일째와 7일째에 증식하는 세포의 수가 대조군에 비해 많았으며, GFAP 면역반응 양성을 보이는 세포가 생후 3일째부터 관찰되기 시작하였다. 생후 14일째에는 대조군의 경우보다 더 길고 뚜렷한 가지를 갖는 별아교세포가 신경세포 사이로 관찰되었다. 대뇌피질 조직 내 GFAP 단백질의 양적변화를 분석한 결과, BPA 노출군은 대조군에 비해 유의한 GFAP 단백량의 증가를 보였다. 결 론:이와 같은 사실을 종합해 볼 때, BPA에의 노출은 출생 후 소아 대뇌피질조직 내 조기 신경발생을 초래할 가능성이 높다고 생각된다. 현재로서는 소아기 대뇌피질조직 내 조기 신경발생이 청소년기 및 그 이후에 어떠한 병적 영향을 미칠지에 대해서는 특별한 예측이 불가능하다. 향후, 이에 대한 명확한 신경학적 연구 및 평가가 필요하다고 생각한다. Purpose : Bisphenol A (BPA), a plasticizer, shows estrogenic activity at low concentrations in cells expressing estrogen receptors, and therefore, it is classified as an endocrine disruptor. Although many studies have focused on the toxicity of BPA to the reproductive and immune systems, relatively less attention has been given to the effect of BPA on the central nervous system. Therefore, the purpose of this study was to investigate the changes in cell proliferation and differentiation during infant brain development in BPA-exposed pregnant rats. Methods : Two different doses of BPA were exposed to pregnant rats: (1) a low dose (0.01 mg/kg-bw/day) and (2) a high dose (1 mg/kg-bw/day). Infant brains were excised at days 3, 7, and 14 after birth, and tissues were processed for histological and biochemical analyses. Results : Immunohistochemistry for proliferating cell nuclear antigen (PCNA) showed that although cells in the cerebral cortex at days 3 and 7 after birth were highly proliferating, the cells at day 14 divided less often. Immunopositive cells for glial fibrillary acidic protein (GFAP) were observed from days 7 to 14 in control tissues. Western blotting clearly showed that exposure to BPA in pregnant rats resulted in increased GFAP protein expression in the infant rat brain compared to the controls. Conclusion : Exposure to BPA during the gestational period might result in precocious ne urogenesis in the infant rat brain.
서울시 주택 예상투자이익 추정과 영향요인에 대한 시론적 분석 - 2010-2018년 주택 실거래가를 중심으로 -
안혜성(Ahn, Hye-Sung),강창덕(Kang, Chang-Deok) 한국지역학회 2020 지역연구 Vol.36 No.1
이 연구는 투자이론에서 활용되고 있는 토빈의 Q 개념을 적용하여 투자이익을 측정하고 이를 통해 서울 주택시장을 이해하고자 한다. 구체적으로 서울시 아파트와 연립·다세대주택을 대상으로 2010년부터 2018년 까지 투자이익을 추정하고 공간계량모형을 이용하여 투자이익에 영향을 주는 요인들을 살펴보았다. 투자이익은 실거래가격에서 대체비용(토지비용+건축비용)을 빼는 방식과 실거래가격 대비 대체비용의 비율로 각각 추정하였다. 분석결과를 보면, 투자이익은 2018년으로 갈수록 더 커졌고 강남·서초구 및 한강 주변에서 투자이익이 높게 나타났으나 투자이익의 시공간적 변화양상은 아파트의 경우 뚜렷한 반면에 연립·다세대주택은 산발적·국지적으로 나타났다. 공간계량모형 분석결과는 주택유형과 상관없이 고밀·신축개발이 많은 지역에서 투자이익이 높았다. 이 연구의 접근방법과 결과는 향후 주택 공급 정책, 투자이익 환수, 지역 경쟁력 측정, 가격 거품 측정 등에 대한 논의를 위한 기초 자료가 될 것이다. Estimating investment profits of real estate is critical to understand real estate markets and create relevant policy as real estate market and capital market combines closely. Thus, this study applied the concept of Tobin’s Q to estimate investment profits for apartments as well as row-houses and multi-family homes in Seoul from 2010 to 2018. Investment profits were estimated by two approaches: subtracting the replacement cost from the transaction price and calculating ratio of the transaction price to the replacement cost, respectively. The spatio-temporal changes in investment profits were apparent in apartments compared with row-houses and multi-family homes. As a result of analyzing the spatial econometrics models, the investment profit was higher in the area with high density and new developments regardless of the housing types. The framework and key findings would be the effective reference to understand residential investment behavior, create relevant housing policy, introduce value capture of windfall, measure regional competitiveness, and estimate housing bubble.
안혜성(Hye Seong Ahn),장진영(Jin-Young Jang),이승은(Seung Eun Lee),양성훈(Sung Hoon Yang),이건욱(Khun Uk Lee),김선회(Sun Whe Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.1
Purpose: Because of the rarity of primary duodenal adenocarcinomas, the factors affecting the management and survival of patients with this disease remain controversial. This study analyzed the nineteen-years of experience gained at one institution to define the surgical management and outcomes of patients with primary duodenal adenocarcinomas. Methods: A retrospective review of 77 patients, who underwent surgery for a primary duodenal adenocarcinoma at Seoul National University Hospital, between May 1985 and April 2004, was undertaken. The dermographics symptoms, operative variables, surgical pathology and survival data were analyzed. Results: A curative resection was performed in 40 patients (51.9%); a pancreaticoduodenectomies and/or resection of other organs, pancreas head resection with a duodenal segmentectomy and a segmental duodenectomy and resection of another organ in 37, 2 and 1, respectively. The remaining 37 patients underwent a palliative resection or bypass. The hospital mortality and complication rates were 2.6% (2 patients) and 42.9% (33 patients), respectively. The overall 5-year survival was 26.8%. The 5-year survival for the curative resection group was 42.7%, whereas that for the palliative surgery group was 0%. In a univariate analysis, nodal metastasis was found to have a significant negative impact on survival after a curative resection (P=0.028). The patients’ age, sex, operative procedure, tumor size, histologic type, differentiation and tumor depth had no influence on survival. Conclusion: A curative resection is associated with increased survival in patients with a duodenal adenocarcinoma. Following a curative resection, nodal metastasis is an independent prognostic factor. Therefore, the early diagnosis should be sought to achieve a curative resection and increased survival. As a curative resection, a pancreati-coduodenectomy is usually required, and a segmental duodenal resection may be appropriate in selected patients, especially in early duodenum cancers.