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The association between carbon and nitrogen stable isotope ratios of human hair and hypertension
안성복,Jong‑Ku Park 대한고혈압학회 2023 Clinical Hypertension Vol.29 No.-
Background: The relationship between stable isotope ratios and dietary protein sources has been reported. However, few studies have examined the effect of stable isotope ratios on metabolic risk in humans. We investigated whether the stable isotope ratios of carbon and nitrogen in human hair are associated with blood pressure and hypertension. Methods: We conducted a cross-sectional study of 392 subjects (228 men and 164 women). Hair samples of the subjects were used for the measurement of stable isotope ratios of carbon (δ13C) and nitrogen (δ15N). Results: The δ13C and δ15N values showed positive correlations with diastolic blood pressure in the subjects without antihypertensive medication. In the subjects without antihypertensive medication, the multivariable-adjusted odds ratio (95% confidence interval) for hypertension was 1.55 (1.04–2.30) per 1‰ increase in δ15N and 1.22 (0.86–1.73) per 1‰ increase in δ13C, respectively. However, in the subjects with antihypertensive medication, neither δ13C nor δ15N values showed a significant association with hypertension. Conclusions: The stable isotopic ratio of nitrogen in scalp hair is independently associated with hypertension in subjects without antihypertensive medication. The hair δ15N value might be used as a surrogate marker to screen a high-risk population for hypertension.
젊은 성인에서 교정 QT간격과 심혈관질환 위험요인의 관련성: 강화연구
안성복,김현창,허남욱,하경수,장후선,김진배,서일,Ahn, Song-Vogue,Kim, Hyeon-Chang,Hur, Nam-Wook,Ha, Kyoung-Soo,Jang, Hoo-Sun,Kim, Jin-Bae,Suh, Il 대한예방의학회 2006 예방의학회지 Vol.39 No.6
Objectives : Prolongation of the heart rate-corrected QT (QTc) interval has been reported to be associated with cardiovascular morbidity and mortality. However, few studies have examined the relationship between the QTc interval and cardiovascular risk factors in young healthy people, The aim of this study was to examine the associations between the QTc interval and cardiovascular risk factors in young healthy adults. Methods : This study was performed as part of the Kangwha study, which started in 1986, and is an on-going follow-up study on blood pressure and related cardiovascular risk factors. In follow-up examinations during 2005, cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry and carotid ultrasonography, were measured, and questionnaires on health behaviors completed by 127 men and 149 women aged 25 years. The QTc interval was measured on the resting 12-lead electrocardiogram using an automatic analysis program. Results : The mean QTc interval was significantly longer in women $(419{\pm}17ms)$ than in men $(405{\pm}17ms)$ (p<0.001). A significant positive correlation was found between the QTc interval and waist-hip ratio (p=0.030) in men. Women showed a positive correlation between the QTc interval and systolic blood pressure (p=0.017). On a multiple regression analysis, the QTc interval was positively associated with the waist-hip ratio in men (p=0.012) and with the systolic blood pressure (p=0.020) in women. Conclusions : In young healthy Korean adults, the QTc interval was independently associated with the waist-hip ratio in men and with the systolic blood pressure in women.
안성복,김인수,조왕수,이문홍,최궤문 한국응용곤충학회 1989 한국응용곤충학회지 Vol.28 No.4
새로운 문제해충을 찾아내려면 작물별로 전국적인 survey가 이루어져야 한다. 인력과 경비면 그리고 수행상의 어려움이 있으므로 경작자나 그 지역의 농촌지도소를 통하여 문의.의뢰된 해충들을 살펴보면 그 해의 대체적인 해충발생상황을 알아볼 수 있다고 생각된다. 농업기술연구소 곤충과에는 1988년 40건의 민원과 의뢰사항이 접수.처리되었다(표 1). 그중 해충동정 및 방제법에 대한 것이 31건, 현지발생행동조사 의뢰 3건, 해충관계자료에 대한 문의가 3건 등이었다. 접수된 민원중에서 일부를 제외하고 각 해충의 발생상황을 작물별로 기술하여 기록을 남김으로서 금후 연구를 의한 기초 자료로 제공코자한다.
안성복,조왕수,임성언,김택조,이문홍,최귀문 한국응용곤충학회 1990 한국응용곤충학회지 Vol.29 No.1
The banana insect pest species and their damages were surveyed from 9 vinyl hoses of Cheju Island on August in 18. A total of 5 pest species wre found ; banana root weevil (BRW) Cosmopolites sordidus Germar (Curculionidae) a wireworm Melonotus sp. (Elateridae), a spider mite teranychid sp. (Tetranychidae), mulberry mealybud Pseudococcus comstocki (Kuwana)(Pseudococcidae), and common cutworm Spodoptera litura (Fabricius)(Noctuidae). Among them, the BRW which attacked the rhizome of banana plant was newly recorded from Korea. It is assumed that the weevil would be introduced from Japan, Philippine or SriLan-Ka wiht the banana seedlings imported during early 1980's. 濟州遺 바나나 栽培하우스內에 發生한 蟲害種類 및 加害樣補을 1988年 8月初 9個農園에서 調査하였다. 그 結果 發見된 害蟲은 바나나바구미(Cosmopoiites sordidus (Germar)), 방아벌레 I種(Melanotus sp.), 담배거세미나방(Spodoptera litura (Fabricius)), 가루깍지 벌레(Pseudococcus comstocki (Kuwana)), 응애류 1種(Tetranychid sp.) 等 5種이었다. 바나나바구미는 幼蟲이 地下莖에 坑道를 뚫고 加害하여, 바나나헛줄기 밑부와 地下莖이 細菌複合感梁에 의해 썩게 만들었고 幼蟲 20마리 정도가 加害하면 식물체가 죽었다. 바나나바구미는 서귀포시 법환동, 강정동 -帶와 남제주군 남원읍에 發生하였고 '80年代初 일본, 필리핀, 스리랑카 等地에서 輸入한 바나나에 묻어 流入 되었을 것으로 추정된다. 기타의 害蟲은 國內에 分布하던 것이 하우스내로 이동하여 發生한 種들이었다.
우리나라 일부 의학 학술지에 게재된 의약품 광고의 과학적 근거에 대한 평가
안성복,최원,김철준,최성준,이강희,하경수,김현창 한국의료QA학회 2005 한국의료질향상학회지 Vol.12 No.1
Background : The promotion and advertisement of pharmaceuticals should be based on evidence from clinical trials. We conducted this study to assess whether the pharmaceutical advertisement claims in Korean medical journals had relevant references, and whether the claims were supported by the references. Methods : We reviewed pharmaceutical advertisements in five Korean medical journals issued during the first half of 1999 and during the first half of 2004. Three investigators independently reviewed the advertisements to see whether the studies quoted to endorse the advertising messages supported the corresponding claims. Using multiple logistic regression analyses, we investigated which factors were associated with the quality of the advertisement claims. Results : From the 550 advertisements in the five journals, we identified 157 different advertisements and 475 different promotional claims. Only 149 claims had at least one reference, and 105 claims had references of published article. We could find supporting evidences in the 90 claims. The factors which were associated with the quality of advertisement claims were category of drugs, category of claims, and the manufacturer characteristics. Claims for cardiovascular and endocrine drugs, and claims on efficacy, and claims of multinational company were more evidence-based. Conclusion : Majority of the pharmaceutical advertisement claims in Korea did not have appropriate references. Drug category, claim category, and the manufacturer characteristics were associated with the quality of advertisement claims, and the manufacturer characteristics was the most important determinants.