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Taeeum-type people in Sasang constitutional medicine have a reduced mitochondrial metabolism
심은보,이시우,김종열,임채헌,엄융의 한국한의학연구원 2012 Integrative Medicine Research Vol.1 No.1
Sasang constitutional medicine (SCM) is a traditional form of medicine that is widely used in Korea to clinically diagnose and treat disease. The main characteristic of SCM is its classification of people according to physical constitution. The theory asserts that four different types of physical constitution exist: Taeyang, Soyang, Taeeum, and Soeum. One noticeable clinical observation in SCM is that Taeeum-type people are prone to obesity. Although extensive clinical investigations have shown this tendency in SCM, no scientific hypothesis has been proposed to delineate its mechanism. According to SCM theory, Taeeum-type people have a hypoactive lung system and a hyperactive liver system. In this paper, we propose a new hypothesis explaining this finding from a physiological viewpoint. A functional weakness in the lung system indicates intrinsic hypoactivity in the consumption of metabolic energy, therefore we deduced that the tendency can easily induce body weight gain via an increase in anabolism.
Biophysical Analysis of the Role of the Cross-Bridge Sliding Rate in Modulating Heart Mechanics
심은보,최성욱 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.6
We investigated the effects of the cros-bridge sliding rate on heart mechanics from cels to system by using a mathematical model. The alternation of the sliding effect in the cros-bridge filament is mediated through phosphorylation by beta receptor stimulation, which is closely related to heart failure. The formula and related variables were introduced to expres the effect of sliding on celular mechanics. To delineate the sliding effect, we developed a celular mechanics model that simulated sequential celular events starting from membrane excitation to contraction. The isotonic simulations with variable loadings showed that the force velocity relation (FVR) was closely related to the cros-bridge sliding rate(CBSR), which quantitatively indicated the sliding effect in cros-bridge dynamics. In the cel system model, computational results showed that the effect of the sliding rate on heart mechanics was mediated by a change in cros-bridge elongation during contraction, which sequentialy induced changes in both the cros-bridge-generated force and the systolic presure of the left ventricle (LV). Therefore, an increased CBSR induced an increase in the cros-bridge-generated force and the peak LV pressure. It also resulted in upward movement of the FVR curve, indicating that the CBSR could, like noradrenalin, change the heart's contractile state. Simulation results for various preload and afterload changes implied that the afterload-stroke volume (SV) and the Frank-Starling curve of the preload also grew with increasing CBSR.
심은보,임채헌,김중재,김종열 한국한의학연구원 2017 Integrative Medicine Research Vol.6 No.3
Background: Those classified as Tae-Eum (TE)-type people in Sasang constitutional medicine (SCM) are prone to obesity. Although extensive clinical observations have confirmed this tendency, the underlying physiological mechanisms are unknown. Here, we propose a novel hypothesis using integrative physiology to explain this phenomenon. Methods: Hypoactive lung function in the TE type indicates that respiration is attenuated at the cellular level—specifically, mitochondrial oxygen consumption. Because a functional reduction in cellular energy metabolism is suggestive of intrinsic hypoactivity in the consumption (or production) of metabolic energy, we reasoned that this tendency can readily cause weight gain via an increase in anabolism. Thus, this relationship can be derived from the graph of cellular metabolic power plotted against body weight. We analyzed the clinical data of 548 individuals to test this hypothesis. Results: The statistical analysis revealed that the cellular metabolic rate was lower in TE-type individuals and that their percentage of obesity (body mass index >25) was significantly higher compared to other constitutional groups. Conclusion: Lower cellular metabolic power can be an explanation for the obesity trend in TE type people.