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두침치료를 시행한 중추성 마비 말장애(Dysarthria) 환자의 모음 공간 평가
신유정,박종혁,백경민,장우석,최양규,Shin, Yoo-Jeong,Park, Jong-Hyuck,Baek, Kyung-Min,Chang, Woo-Seok,Choi, Yang-Kyu 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.2
Objective : To investigate the therapeutic effect of scalp acupuncture on dysarthria after stroke. Methods : A-B model in single subject research. The experimental group of 7 members received scalp acupuncture and the control group of 5 nothing for dysarthria itself. Five single vowels were recorded by voice recorder and measured for 1st & 2nd formant. By the formants, a vowel space was made according to each one of the patients. Praat program was used for evaluation. Results : 4 cases in the experimental group showed significant change and just 1 case of the none-operated group got better. Conclusion : In this study, it's proven that acupuncture treatment might have positive efficacy on dysarthria cases. At this moment, more clinical reports are needed for objective oriental medical study.
신유정 ( Yoo Jeong Shin ),조세은 ( Se Eun Cho ),성창옥 ( Chang Ohk Sung ),최철훈 ( Chel Hun Choi ),배덕수 ( Duk Soo Bae ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.9
The incidence of cancer from adenomyosis is rare. Previously, only two cases of clear cell adenocarcinoma (CCA) arising from adenomyosis have been reported in English literature. Here, we report a case of CCA arising from adenomyosis. A 52-year-old postmenopausal Korean woman presented with complaints of vaginal bleeding and back pain. Endometrial biopsy revealed endometrial polyp with atrophic change and transvaginal ultrasonography showed myomas with cystic change. Magnetic resonance imaging revealed a cystic degenerative mass consistent with leiomyoma in the posterior portion of uterus body. And the serum level of CA-125 was 17.7 U/mL. Hysterectomy revealed a yellow-ten solid mass in the myometrium that was diagnosed as CCA arising from adenomyosis, The tumor was mainly located in the myometrium and transition between adenomyosis and CCA along with endometrial stromal cell was identifi ed, Malignant tumor arising from adenomyosis could be considered as a differential diagnosis when the patient with adenomyosis and intact endometrial surface complained of vaginal bleeding.
($A{\beta}-oligomer$로 유도된 Neuro2A 세포주에서 용담사간탕(龍膽瀉肝湯)의 치매 억제 효과
김해수,신유정,박종혁,김승모,백경민,박치상,Kim, Hae-Su,Shin, Yoo-Jeong,Park, Jong-Hyuk,Kim, Seung-Mo,Paek, Kyung-Min,Park, Chi-Sang 대한한의학회 2008 대한한의학회지 Vol.29 No.2
Objective: To investigate the effects of Yeongdamsagantang (YDGT) on apoptosis of neuronal cells that can result in dementia. Method: The water extract of the YDGT was tested in vitro for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with $A{\beta}$ oligomer-related dementias. $A{\beta}$ oligomers derived from proteolytic processing of the ${\beta}-amyloid$ precursor protein (APP), including the $amyloid-{\beta}$ peptide $(A{\beta})$, play a critical role in the pathogenesis of Alzheimer's disease. A neuroblastoma cell line stably expressing an $A{\beta}$ oligomerassociated neuronal degeneration was used to investigate if YDGT inhibits formation of $A{\beta}$ oligomer. To measure the ATP generating level in mitochondrial membrane, luciferin/luciferase luminescence kit (Promega) and luminator was used, and to survey the protein's apparition, confocal microscopy was used. Result: $A{\beta}oligomer$ had a profound attenuation in the increase in CT105 expressing neuro2A cells from YDGT. Experimental evidence indicates that YDGT protected against neuronal damage from cells, but its cellular and molecular mechanisms remain unknown. We demonstrated that YDGT inhibited formation of $amyloid-{\beta}$ $(A{\beta})$ oligomers, which were the behavior, and possibly causative, features of AD. The decreased $A{\beta}$ oligomer in the presence of YDGT was observed in the conditioned medium of this $A{\beta}oligomer-secreting$ cell line under in vitro. In the cells, YDGT significantly attenuated mitochondrion-initiated apoptosis. Conclusion: (i) a direct $A{\beta}$ oligomer toxicity and the apoptosis initiated by the mitochondria; and (ii) multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of $A{\beta}$ oligomer aggregation, underlie the neuroprotective effects of YDGT.
도담탕(導痰湯)이 $C_{2}C_{12}$세포주로부터 myostatin발현에 의한 심근에 미치는 영향
이유승,신유정,박종혁,김승모,백경민,박치상,Lee, You-Seung,Shin, Yoo-Jeong,Park, Jong-Hyuk,Kim, Seung-Mo,Paek, Kyung-Min,Park, Chi-Sang 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1
Myostatin, a negative regulator of myogenesis, is shown to function by controlling the proliferation of myoblasts. In this study we show that myostatin is an inhibitor of myoblast differentiation and that this inhibition is mediated through Smad 3. To determine MyoD expression by Dodamtang treatment, we compared the expression pattern of $C_{2}C_{12}$ mouse myoblasts that constitutively express myostatin with control cells. In vitro, increasing concentrations of Dodamtang reversibly prevented the myogenic blockage of myoblasts by myostatin expression. ELISA assay, Western and confocal analysis indicated that treatment of Dodamtang to the low serum culture media increased the levels of MyoD leading to the inhibition of myogenic differentiation by myostatin. The stable transfection of $C_{2}C_{12}$ myoblasts with myostatin expressing constructs did rescue MyoD-induced myogenic differentiation. Consistent with this, the treatment of Dodamtang rescued the expression of a MyoD in $C_{2}C_{12}$ myoblasts treated with myostatin. Taken together, these results suggest that induction of MyoD by Dodamtang inhibits myostatin activity and expression via SMAD3 resulting in the rescue of the myoblasts to differentiate into myotubes. Thus we propose that myostatin action by Dodamtang plays a critical role in myogenic differentiation and that the muscular hyperplasia and hypertrophy seen in animals that blockage of functional myostatin is because of deregulated proliferation and differentiation of myoblasts.
Mouse 유래 $C_2C_{12}$세포주에서 청심연자탕(淸心蓮子湯)의 심근세포 손상 억제 효과
윤현덕,신오철,신유정,김승모,박치상,Yoon, Hyeon-Deok,Shin, Oh-Chul,Shin, Yoo-Jeong,Kim, Seung-Mo,Park, Chi-Sang 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.2
Determination and differentiation of cells in the skeletal muscle lineage is positively regulated by cell-cell contact. differentiation proteins proposed to mediate this effect include both classical MyoD and MEF members : potential interactions between the promyogenic activities of these classes of protein, however, are unknown. We show here that MyoD and MEF, two promyogenic family members that determine to each other in a cis fashion, form ineraction with MyoD- and MEF. These proteins contain myosin heavy chains and are enriched at sites of cell-cell contact between myoblasts, Therefore, In differentiation of MyoD MEF from CST (Chungsimyeonjatang) interact dependently, suggesting that the interactions occur in a cis fashio : consistent with this conclusion, MyoD-mediated differentiation is required for myoblast to occur by CST. Inhibition in myoblasts of a MyoD by STP in its ability to associate with MEF interferes with differentiation as assessed by morphological and transcription level, suggesting that this interaction is functionally important in myogenesis. Also, some of the differentiation-mediated proteins that are required for myogenesis seem to be based on interdependent activities of promyogenic classical SMAD-subfamilly.