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약물 과민반응 증후군 바이러스 재활성화 연관성에 대한 문헌 고찰
송우정 ( Woo Jung Song ),장윤석 ( Yoon Seok Chang ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.2
Drug hypersensitivity syndrome is a severe adverse drug reaction characterized by skin eruption and systemic manifestations, such as fever, eosinophilia, lymph node enlargement, hepatitis and renal dysfunction. The pathogenic mechanism of this syndrome is considered multifactorial but still remains to be elucidated. An interesting point is a possible association between drug reaction and herpesvirus reactivation. Since the first case reported by Descamps et al in 1997, there have been scores of reported cases suggesting this association, also being supported by clinical observation of flare-up of disease during the recovery phase. The purpose of this review is to describe its clinical characteristics and to evaluate the possibility of drug and viral interactions in the development of this syndrome through a literature review. (Korean J Asthma Allergy Clin Immunol 2011;31:77-83)
만성 기침의 새로운 임상 접근법: 최근 진료 지침을 기반으로
송우정 ( Woo-jung Song ),김상훈 ( Sang-hoon Kim ) 대한내과학회 2019 대한내과학회지 Vol.94 No.6
The cough reflex is a vital protective mechanism for the lower airways against aspiration, but when dysregulated, it becomes a clinical problem. Indeed, chronic cough is an important clinical issue as it is common in the general population and causes consid-erable morbidity. Anatomic diagnostic protocols were the first breakthrough in the management of patients with chronic cough; however, as systematic approaches are not always successful, a new paradigm of cough hypersensitivity syndrome has been proposed. The introduction of this paradigm has provided new opportunities for managing chronic cough, including development of new cough assessment tools and effective cough control therapies. However, it also warranted re-appraisal of existing clinical evi-dence and refinement of our clinical pathways. Against this background, international and domestic evidence-based practice guide-lines based on a strict methodology have been published recently. In this review, we introduce clinical approaches based on the con-cept of cough hypersensitivity syndrome and discuss key aspects of recently published guidelines for chronic cough in adults. (Korean J Med 2019;94:471-484)
Allopurinol 투여 후 발생한 심한 약물 이상 반응 13예의 임상적 고찰
송우정 ( Woo Jung Song ),이상민 ( Sang Min Lee ),양민석 ( Min Seok Yang ),이소희 ( So Hee Lee ),권혁수 ( Hyouk Soo Kwon ),김덕인 ( Deok In Kim ),박창한 ( Chang Han Park ),손성욱 ( Seong Wook Sohn ),김상헌 ( Sang Heon Kim ),박흥우 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
Background: Allopurinol-induced hypersensitivity reactions are rare but increasing recently in clinical practice; however, little has been known about its clinical characteristics and underlying mechanism. Objective: The goal of this study was to obtain more accurate information on the clinical feature and course of allopurinol-induced hypersensitivity reactions. Method: We retrospectively reviewed medical records of 13 patients diagnosed with allopurinol-induced severe cutaneous adverse drug reactions between September, 2003 and April, 2006. Result: All patients (n=13) showed skin rash as an initial manifestation. Eleven patients had severe skin rash and multiple organ involvements such as peripheral blood eosinophilia, hepatitis, or renal dysfunction. They were diagnosed with drug hypersensitivity syndrome (n=5), Stevens-Johnson syndrome (n=5), or toxic epidermal necrolysis (n=1). There was one mortality with toxic epidermal necrolysis. Conclusion: Allopurinol-induced hypersensitivity is associated with significant morbidity, and potentially life-threatening. Therefore, attention should be given when prescribing allopurinol. (Korean J Asthma Allergy Clin Immunol 2006; 26:225-232)
권재우 ( Jae-woo Kwon ),송우정 ( Woo-jung Song ),김민혜 ( Min-hye Kim ),임경환 ( Kyung-hwan Lim ),양민석 ( Min-suk Yang ),정재우 ( Jae-woo Jung ),이정민 ( Jeongmin Lee ),서동인 ( Dong In Suh ),신유섭 ( Yoo Seob Shin ),김세훈 ( Sae 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.4
Fractional exhaled nitric oxide (FeNO) is a biomarker for type 2 inflammation in the airways, and its measurement has the distinct strengths of being simple, rapid, convenient, and reproducible. Since the discovery of FeNO in the 1990s, its measurement tools have been extensively developed and validated by several researchers. In particular, FeNO showed the potential to support the diagnosis of asthma and eosinophilic bronchitis. Since it has begun to be widely utilized in clinical research areas as well as daily practice, we summarized the standardized diagnostic procedures and suggested the clinical application of FeNO measurement in Korean population. (Allergy Asthma Respir Dis 2017;5:185-192)
동정맥루 기능이상 진단에 대한 이학적 검사의 정확도 : 정맥조영술 소견과의 비교 Comparison with Venographic Findings
최정란 ( Jung Ran Choi ),김영수 ( Young Soo Kim ),윤선애 ( Sun Ae Yoon ),원유동 ( Yoo Dong Won ),손영숙 ( Young Suk Son ),송우정 ( Woo Jung Song ),송호철 ( Ho Cheol Song ),김용수 ( Yong Soo Kim ),장윤식 ( Yoon Sik Chang ),방병기 ( 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.5
노인 천식에서 혈중 미량 영양소와 임상 양상의 연관성 분석
이소희 ( So-hee Lee ),송우정 ( Woo-jung Song ),박흥우 ( Heung-woo Park ),김세훈 ( Sae-hoon Kim ),박혜경 ( Hye-kyung Park ),김상헌 ( Sang-heon Kim ),권용은 ( Yong Eun Kwon ),김태범 ( Tae-bum Kim ),이병재 ( Byung-jae Lee ),지영구 ( 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.4
Purpose: The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study aimed to evaluate the associations between serum levels of micronutrients, including several vitamins and minerals, and clinical features of the elderly asthmatics. Methods: A total of 317 asthmatics aged 65 or older were enrolled. Serum levels of vitamin D, vitamin B12, folate, Mg, and Se were measured and then the associations between serum micronutrient levels and clinical features of elderly asthmatics were evaluated. Results: Positive correlations with significance among serum levels of vitamin B12, vitamin D, and folate were found. Serum micronutrients levels showed no difference according to the atopic status and symptom severity. The serum folate level was significantly associated with forced expiratory volume in 1 second, and serum vitamin B12 and folate levels were significantly associated with serum total IgE level. Interestingly, elderly asthmatics with exacerbation history showed significantly lower serum levels of vitamin D and Mg, but significantly higher serum levels of Se. Conclusion: Serum levels of micronutrients, such as vitamin D, vitamin B12, Mg, folate, and Se, were significantly associated with some clinical features of elderly asthmatics. Clinical meanings of these associations need to be investigated further. (Allergy Asthma Respir Dis 2017;5:223-227)
이서영 ( Suh Young Lee ),송우정 ( Woo Jung Song ),정재우 ( Jae Woo Jung ),박흥우 ( Heung Woo Park ),조상헌 ( Sang Heon Cho ),민경업 ( Kyung Up Min ),강혜련 ( Hye Ryun Kang ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.2
Purpose: Chronic urticaria is a common disease, but clinically, it is not easy to treat and predict the prognosis since the causes and pathophysiology of chronic urticaria remain unknown. Many studies have been done that defined the association between chronic urticaria and thyroid autoimmunity. However, the clinical role of antithyroid antibodies (ATAs) has not been fully evaluated. Methods: We retrospectively reviewed the medical records of patients with chronic urticaria and compared the duration of treatment, the frequency of steroid use, and the level of medications used in the treatment of urticaria according to the presence or absence of ATAs including the antithyroglobulin (anti-TG) antibody, antithyroid peroxidase antibody, and antithyrotropin-stimulating hormone receptor antibody. Results: A total of 194 patients with chronic urticaria was enrolled; of which, 108 patients were free of ATAs and 86 patients had at least one ATA. The treatment duration was significantly longer in the anti-TG antibody-positive patients compared to the patients without ATAs (39.6±10.2 months/18.0±3.4 months, P=0.02). The patients with the anti-TG antibody also showed more frequent steroid use than that of the patients without the anti-TG antibody (2.1±0.4/1.1±0.3, P=0.05). The level of medications used to achieve control of urticaria tended to be higher in patients with the anti-TG antibody than in the ATA-negative patients group. Conclusion: From this study, we suggest that the evaluation of thyroid autoantibodies, especially the anti-TG antibody, can be a useful tool in predicting the prognosis and making decisions for the treatment strategy of patients with chronic urticaria. (Allergy Asthma Respir Dis 2013;1:151-156)