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정상희(Sang Hee Jeong),박철범(Cheol Beom Park),한범석(Bum Seok Han),강창수(Chang Soo Kang),정미혜(Mihye Jeong),성하정(Ha Jung Sung) 한국농약과학회 2011 농약과학회지 Vol.15 No.2
The use of chemical products to enhance and improve life is a widespread worldwide practice. In spite of the benefits of these products, there is the potential of chemicals for adverse effects to people or the environment. The globally harmonized system (GHS) of classifying and labeling chemicals that was recommended by the United Nations in 2003, has been introduced globally since 2008. Compare to the classification criteria of agricultural formulations today, classification criteria of GHS is different partly, One pictogram is removed and 3 pictograms are introduced newly. The classification criteria of GHS will be changed preferentially and implemented gradationally to hazard products.
ICR마우스에서 phenytoin의 최기형성 및 dimethyl sulfoxide의 항최기형 효과
이재권,이창업,이문한,류판동,조명행,성하정,박진봉,Lee, Jae-kwon,Lee, Chang-eop,Lee, Mun-han,Ryu, Pan-dong,Cho, Myung-haing,Sung, Ha-jung,Park, Jin-bong 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.4
Phenytoin(PHT), a commonly prescribed anticonvulsant, has been known as a teratogen in experimental animals and human. However, PHT has strain-specific teratogenic effects for mice and human. Dimethyl sulfoxids(DMSO) has been known to antagonize the teratogenic effects of secalonic acid D, a toxic mold metabolite that has similar teratogenic effects to PHT. Therefore, this study was performed to examine the embryopathic effects of PHT in terms of treatment period and the antiteratogenic effect of DMSO in ICR mice. PHT(75mg/kg, BW) was administered intrapetitoneally on day 10, 10-11 and 10-12 of gestation with or without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Major malformation of fetuses treated with PHT on day 10, 10-11 and 10-12 of gestation was cleft palate, and the percentages of fetus with cleft palate were 14.5%, 31.7% and 51.7%, respectively. Also, there was a significant decrease of cleft palate from 51.7% in PHT alone group to 30.8% in PHT plus DMSO group. Our findings suggest that cleft palate is one of major malformation by PHT treatment in ICR mouse and DMSO has strong antiteratogenic effect.
Phenytoin의 태아 구개열 유발과 모체 혈청 Corticosterone 증가에 대한 Dimethyl Sulfoxide 억제 작용
이재권,이창업,이문한,류판동,이영재,성하정,Lee, Jae-Kwon,Lee, Chang-Eop,Lee, Mun-Han,Ryu, Pan-Dong,Lee, Young-Jae,Sung, Ha-Jung 한국독성학회 1992 Toxicological Research Vol.8 No.2
It is well known that phenytoin (PHT), a commonly prescribed anticonvulsant, has teratogenicity in experimental animals and human. The major malformation induced by PHT in mouse is cleft palate. The mechanisms of the embryotoxic effects of PHT are unknown. However, PHT and synthetic glucocorticoids share several features with respect to their teratogenicity, and it was known that PHT increased maternal corticosterone level. Therefore PHT-induced cleft palate may be mediated indirectly by elevated maternal corticosterone. Recently it was reported that secalonic acid Dinduced cleft palate and elevated endogenous corticosterone level, and that such effects were antagonized by DMSO. The purpose of this work was to investigate whether the elevated maternal corticosterone is associated with the teratogenicity of PHT in the ICR mouse fetuses by treatment with PHT or PHT plus DMSO. PHT (74mg/kg, BW) was daily administered intraperitoneally on day 10~12 of gestation with and without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Maternal serum corticosterone and fetal PHT levels were determined by HPLC. The results are summarized as follows. 1)The percentage of cleft palate incidense in fetuses following treatment with PHT on day 10~12 of gestation was 51.7%. 2)There was a significant decrement in the cleft palate incidence in fetuses to 30.8% in the group treated with PHT plus DMSO compared with 51.7% in that with PHT alone. 3) Maternal serum corticosterone levels following treatment with PHT on day 10~12 of gestation increased by 116~343% compared with that of vehicle control. Such effect was antagonized by DMSO. 4)PHT concentration in the fetuses was not affected by DMSO. These results suggest that PHT-induced cleft-palate in fetuses seems to be closely associated with the elevation of maternal corticosterone level.
SD 랫드에서 혹명나방 저항성 유전자 변형 낙동벼의 13주 경구 반복투여 독성에 관한 연구
서동석(Dong-Seok Seo),권민(Min Kwon),성하정(Ha-Jung Sung),박철범(Cheol-Beom Park) 한국농약과학회 2011 농약과학회지 Vol.15 No.2
We investigated the systemic effects of leaf folder (Cnaphalocrocis medinalis) resistant rice(transgenic rice, Nakdongbyeb) in Sprague-Dawley rats for 13 weeks. Leaf folder resistant rice was added to the diet at percentage levels of 0, 5 and 20 percentage/feeder and was administered for 13 weeks. The results did not show any changes in food and water intake. There were also no biologically significant changes in both body and organ weights, hematological and blood biochemical parameters, autopsy and histopathology between the treatment and control groups. Based on these results, no observed adverse effect level (NOAEL) of transgenic rice was considered to be more than 10,000 ㎎/㎏ b.w. under the conditions of the present study.
이제봉(Je-Bong Lee),정미혜(Mi-Hye Jeong),성하정(Ha-Jung Sung),이해근(Hae-Keun Lee),양재설(Jae-sul Yang) 한국농약과학회 2001 농약과학회지 Vol.5 No.4
Tank mixing application of pesticides has been used to reduce labor and to control wide spectrum of pests, but it may cause significant pesticide poisoning on human and animals due to carelessness. The toxic response of pesticides for the tank mixtures and mixtures was investigated to determine acute toxicity and enzymatic change using experimental animals. Acute oral toxicity and acute dermal toxicity were tested by RDA test guideline. The LD?? was calculated by probit analysis method and cholinesterase was measured with automatic analyzer. The toxicities were generally higher than estimated toxicities in tank mixing and mixture. Serum cholinesterase activity was inhibited more than expected at the dose levels of 1/5, 1/10 and 1/20 of LD??. Therefore, the results of this study showed that acute toxicity caused by the pesticide mixtures should be considered before the tank mixing method is applied.
붉은곰팡이병에 감염된 맥류의 실험동물에 대한 안전성 평가
이제봉(Je-Bong Lee),정미혜(Mi-Hye Jeong),성하정(Ha-Jung Sung),이해근(Hae-Keun Lee),오병렬(Byung-Youl Oh) 한국농약과학회 2001 농약과학회지 Vol.5 No.4
In order to investigate the harmful effects of Fusarium, producing mycotoxins, contaminated cereals, two months feeding study was carried out in SPF-ICR mice. Mice diets were incorporated with 30% Fusarium infected wheat, nepal barley or barley. The wheat was processed to flour. The nepal barley and barley were polished by 68% and 58%, respectively. The cereal incorporating amount in mice diet were 0, 10, 30 and 50% for each processed cereal. Five week-old mice were fed with the prepared diet for 2 months. The effects of Fusarium contaminated cereals on the mice were observed after the feeding. The rates of body weight gain, diet and water consumption were not changed. There were no significant changes on hematology, blood biochemistry, gross and histopathological evaluation, organ weights in all treatment groups. These results suggest that the diets have no deleterious effects to ICR mice.
Octachlorostyrene의 환경중 노출평가에 관한 연구
김용석 ( Yong Seok Kim ),전용배 ( Yong Bae Jeon ),김태형 ( Tae Hyoung Kim ),성하정 ( Ha Jung Sung ),이규승 ( Kyu Seung Lee ) 한국환경농학회 2009 한국환경농학회지 Vol.28 No.2
Octachlorostyrene(OCS) has been persisted in environment because it has not been decomposed easily. And, it has been known as highly toxic compounds to the environment and human as well as accumulated as high concentrations in a biota through a food chain. Therefore, OCS was monitored for water, soil and fish sampled from the areas where were able to be contaminated with OCS. The recoveries of octachlorostyrene were 93.1~98.6% in water, 90.4~94.8% in soil and 81.5~90.2% in fish and detection limits were 0.0004 mg L-1 for water, and 0.002 mg kg-1 for soil and fish, respectively. OCS was not detected in water, sediment, soil and fish samples from Ulsan, Yeosu, Daejeon and Sihwa industrial complex and in soil sampled nearby incineration plants in all parts of the country. Accordingly, we estimated that there is no risk from exposure of OCS.
오경석(Kyeong Seok Oh),이병무(Byung Moo Lee),성하정(Ha Jung Sung),오홍규(Hong Gyu Oh),임양빈(Yang Bin Ihm),경기성(Kee Sung Kyung) 한국농약과학회 2003 농약과학회지 Vol.7 No.2
The Environmental Impact Quotient(EIQ) has been used to organize the extensive toxicological and soil residue data available on some fruit vegetables pesticides into a usable form for field use. It addresses a majority of the environmental concerns that are encountered in agricultural systems including farm worker, consumer, ecological and environmental safety. The EIQ made use of the rating system by using the EIQ equation. The EIQ of pesticides registered for oriental melon was higher than that of other in terms of farm worker, consumer and environmental safety. Pesticides registered for red pepper showed highest EIQ in ecosystem. The EIQ decreased in order of insecticide>fungicide>herbicide>plant growth regulator. The environment Impact Quotient for the pesticides registered in fruit and vegetables decrease gradually.