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완치 판정 후 8개월째 제1상 IgM항체 역가가 감소하지 않았던 급성 Q열 증례
정지원 ( Ji Won Jeong ),강은석 ( Eun Seok Kang ),오영민 ( Young Min Oh ),이효덕 ( Hyo Deok Lee ),김민 ( Min Kim ),홍용주 ( Yong Joo Hong ),정혜원 ( Hye Won Jeong ),채희복 ( Hee Bok Chae ),성노현 ( No Hyun Sung ),황선도 ( Seon Do 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.1
Acute hepatitis associated with Q fever is rare. Clinician awareness is key for early diagnosis. It can be treated well with macrolides, and symptoms and antibody titers decrease in weeks or months according to the treatment regimen. Successful therapy is accompanied by reduced erythrocyte sedimentation rate, correction of anemia, and resolution of hyperglobulinemia. The risk of chronic Q fever is high if symptoms and antibody titers persist during long-time follow-up testing. Here we report a case of a 54-year-old male with acute Q fever and hepatitis. He complained of fever and headaches and presented with elevated ALT levels around 400 IU/L at admission. Liver biopsy revealed compact fibrin-ring granulomas. He recovered from the acute hepatitis after one week of ciprofloxacin therapy. However, although the patient remained asymptomatic 8 months after completing treatment, his phase 1 and 2 antibody titers remained high. We are unable to determine the disease stage; that is, whether the acute stage was completely resolved due to high titer of antibody.
오상우,최재홍,이지현,이복희,나병규,정상무,박선미,윤세진,정화숙,성노현 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.1
The term $quot;collagenous colitis$quot; was coined by Lindstrom in 1976 to describe the patient with chronic watery diarrhea who had normal rectal mucosa by proctoscopy but who had a thick subepithelial collagenous deposit on biopsy, and now collagenous colitis is recognized as one of the more common causes of chronic diarrhea of obscure origin. But in this country only a few case has been reported. We have seen a 68-year-old man with chronic watery diarrhea with abdominal pain. Physical examination, laboratory and radiologic studies were no abnormal finding. Colonoscopy disclosed grossly normal mucosa through the entire colon but by histologic examination there are chronic inflammation in the lamina propria and thickened subepithelial collagen layer. Symptoms and pathologic findings of patient improved after treatment with sulfasalazine and prednisolone.
CD27에 대한 단클론항체 P7의 DNA 염기서열 분석
이주희, 송형근, 이호창 성노현 충북대학교 의과대학 충북대학교 의학연구소 2013 忠北醫大學術誌 Vol.23 No.2
연구목적 : 면역관용을 유도하기 위한 항체치료제를 개발하기 위하여 보조자극분자로 알려진 CD27에 대한 단클론 항체의 염기서열을 분석하였다. 대상 및 방법 : 항원 CD27에 대한 항체인 P7 단클론항체를 생산하는 하이브리도마를 이용해서 RNA를 추출한 후 이 항체유전자의 중쇄와 경쇄 가변부위의 DNA 염기서열을 분석하였다. 결과 : CD27에 대한 단클론 항체의 중쇄와 경쇄의 염기서열을 확보하였다. 결론 : 면역계의 보조자극분자인 CD27에 대한 단클론항체의 중쇄와 경쇄의 염기서열을 확보하였다.