수용성 카이토산에 의한 체내 방사성스트론튬의 제거

김지열(Ji Yeul Kim),최근희(Keun Hee Choi),김희경(Hee Kyung Kim),김광윤(Kwang Yoon Kim),범희승(Hee Seoung Bom) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.1

N/A Chitosan is known to be one of the natural chelating agents. It is derived from chitin which is a cellu1ose-like biopolymer distributed widely in nature, especially in shellfish, insects, fungi, and yeast. There are two forms of chitosans, water solube and insoluble. The purpose of the present study is to investigate whether water soluble chitosan can be applied to reduce the bioabailability of radiostrontium in foods. We compared the effect of water soluble and insoluble chitosans on the absorption of ingested radiostrontium(85Sr). Three percent water soluble and insoluble chitosan solutions were given ora1ly, and immediately after 85SrCl2 (0.2 μCi) was administered to rats using a orogastric tube. In one group water solube chitosan solution was given for additional 4 days. And in control group no chitosan was given. Each group consisted of 6 rats. The whole-body retention of 85Sr, determined by in vivo counting method, was lower in water soluble chitosan group than that of water insoluble chitosan group and that of control. Urinary excrecion of 85Sr in chitosan-treated rats was higher than that of control. And 5 day ingested group of water soluble chitosan showed least whole retention of 85Sr. In conclusion water soluble chitosan was more effective in reducing bioavailability of ingested radiostrontium in the gastronintestinal tract than insoluble chitosan.

거대 해면상간혈관종 2예

김세종(Sei Jong Kim),윤종만(Chong Mann Yoon),박일종(Il Chong Park),김석빈(Suck Bin Kim),범희승(Hee Seoung Bom),김성렬(Seoung Ryul Kim),양건호(Kim Ho Yang) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1

Benign tumors of the liver are rare, and Henson and associates collected only 34 hemangiomas between 1907 and 1954 at the Mayo Clinic. Most of the cavernous hemangiomas of the liver are small in size, and produce no symptoms during life, but some can reach massive proportions and often present as abdominal masses or causes symptoms by encroachment on adjacent viscera. We have recently been confronted by two case of those large tumors, which has prompted this report with a review of this relatively rare condition. 1) A 32-year-old woman was admitted because of anorexia and indigestion associated with headache, myalgia, mild elevation of fever and weight loss of 5kg in two months. Examination of the abdomen disclosed one finger breadth palpable liver which was slightly tender. A large intrahepatic space-occupying lesion was discovered on radionuclide scan, ultrasonography and computed tomography of the abdomen. Selective hepatic angiography revealed characteristic features of puddling of contrast media along the branches of right and middle hepatic arteries throughout the arterial and venous phase of the angiograms. The resected specimen using Cavitron Ultrasonic Surgical Aspirator was proved to a giant cavernous hemangioma of the liver on microscopic exam. A 32-year-old man came to the hospital because of abdominal pain and a extremely huge mass nearly occupying the whole of his belly. The lesion was found to be a multiloculated highly echogenic mass in the left lobe of the liver on ultrasonography, and a huge hypodense, well-circumscribed homogeneous one with central low density component in the liver on computed tomography of the abdomen. Extensive pooling of contrast media was found throughout the markedly enlarged liver with persistence of tumor stain wliich was measured to be about 25cm in diameter until the late venous phase of the selective hepatic arteriograms. The tumor was considered to be an unresectable one, and we recommended radiation therapy.

지상발표 : 원발성 담도계 암 36예에 대한 임상적 고찰

최성규(Sung Kyu Choi),양대현(Dai Hyun Yang),조정곤(Jong Kon Cho),박해옥(Hae Ok Park),박일종(Il Chong Park),김세종(Se Jong Kim),윤종만(Jong Mann Yoon),범희승(Hee Seoung Bom) 대한소화기학회 1987 대한소화기학회 추계학술대회 Vol.1987 No.-

Dieulafoy`s Disease 3예

범희승,박광숙,양건호,윤종만,김석빈,박일종,김성렬 대한소화기내시경학회 1986 Clinical Endoscopy Vol.6 No.1

Dieulafoys lesion consists of abnormally large gastric submucosal artery which ruptures into the stomach causing massive or recurrent intragikstric bleeding. The lesion is very small and easily overlooked even at laparatomy and can only be correctly diagnosed by endoscopy or arteriography if the patient is actively bleeding. Three patients who were admitted with bleeding of upper gastrointestinal tract and eventually diagnosed as having Dieulafoys lesions were analysed. All were men with age range of 44 to 55 years. All patient were asymptomatic before presenting with hematemesis. Two of the three patients had had history of upper Gl bleeding. One patient used analgesics daily for ureteral colic and two patient drank alcohol excessively. Gastroscopy was performed during the bleeding episode in all three patients. Dieulafoy's lesion was seen in all three cases and in the second case, there was concomittent diffuse petechia in the whole stomach. The lesion was situated on the posterior wall of upper body in one, on anterior wall of upper body in another, lesser curvature side of gastric fundus in the other case. All three patient underwent laparotomy for persistent bleeding and the lesion was suture ligated only in two patients while in one patient vagotomy and pyloroplasty was added. Resection biopsy was performed in two cases and both revealed only normal gastric mucosa. All patients discharged after complete recover.

임신마우스에서 수용성카이토산에 의한 태아의 방사성스트론튬 오염 억제

채기문,최근희,양광희,범희승,김지열,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

핵분열생성물중의 하나인 방사성스트론튬은 임신한 쥐에서 태반을 빠르게 통과하여 태아를 오염시킨다. 독성이 적은 천연착화제로서 마우스체내의 방사성스트론튬(Sr-85)의 제거에 효과적인 것으로 알려진 카이토산을 이용하여 Sr-85의 태반오염억제에 관한 연구를 하였다. 실험군은 일반식이를 공급한 대조군과 임신 17일째에 수용성카이토산을 피하(1% 카이토산), 구강(10% 카이토산), 복강(0.3% 카이토산)으로 주사한 카이토산군으로 분류하였다. 피하주사군은 Sr-85 오염후 카이토산을 주사한 군이며 복강과 구강주사군은 Sr-85 오염젼 15일간 카이토산을 공급한 군이었다. 출산과 동시에 어린마우스의 전신을 측정한 겨러과 출생후 7일째에 대조군이 2.8 ±0.3%의 전신축적율을 나타낸 반면 피하, 구강, 복강, 주사군은 각각 1.2 ±0.1%, 1.4 ±0.1%, 1.6 ±0.2%로 나타났다. 결과적으로 임신한 마우스에서 수용성카이토산은 방사성스트론튬의 태반오염을 유의하게 억제하는 것으로 사료된다. Radiostrontium passes the placental barrier in pregnant rodents very well. Chitosan, a natural nontoxic chelator, was reported to reduce whole body retention of radiostrontium in mice. The aim of the present study was to evaluate water soluble chitosan as a blocking agent of transplacental transfer of radiostrontium in pregnant mice. Twenty pregnant mice wre divided into four groups : control and three groups of chitosan treatment(groups 1 to 3). Sr-85(15KBq in 0.2ml saline) was subcutaneously injected into pregnant mice at the 17th day of pregnancy. In control mice, 0.2ml saline was given 5 hours after the injection of Sr-85. In group 1.1% water soluble chitosan was given subcutanously for two days, twice daily after the injection of Sr-85. In group 2, 10% water soluble chitosan was given orally for 15 days before conception. In group 3, 0.3% water soluble chitosan was injected intravenously for 15 days, once daily before conception. Gamma counting of newborns were done at days 0, 2 and 7 after their births. Whole body retention of Sr-85 in newborns of control mice at days 0, 2, 7 were 3.1 ±0.3%, 2.9 ±0.3%, 2.8 ±0.3% respectively. In experimental groups, whole body retention of Sr-85 was significantly lower thanthat of control(p<0.01) and no statistical difference was noted between them. In group 1, the values were 2.1 ±0.3%, 1.4 ±0.1%, 1.4 ±0.1%, respectively. In group 3, they were 2.1 ± 0.2%, 1.7 ± 0.2%, 1.6 ± 0.2%, respectively. In conclusion, the water soluble chitosan reduced transplacental contamination of radiostrontium in pregnant mice.