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충치균에 대한 생리활성 생약성분의 분리 및 약효평가(2) 호장근의 항균성분과 안정성에 대하여
배기환(Ki Hwan Bae),김봉희(Bong Hee Kim),명평근(Pyung Keun Myung),정경수(Kyeong Soo Chung),백정화(Jung Hwa Baek) 대한약학회 1990 약학회지 Vol.34 No.4
The isolation and identification of an antibacterial component, from Polygoni Radix against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for development of anticariogenic agents. The bioactive component was identified to be emodin. The minimal inhibitory concentration (MIC) of emodin was 100mcg/ml against S. mutans OMZ 176. The bioactive component emodin weakly inhibited beta-lactamase activity with the inhibition ratio of 1.7, 4.3 and 7.6% at the concentration of 50, 100, and 200mcM, respectively. Emodin exhibited slight phototoxicity when analysed by the photohemolysis method.
Anatomical Studies of the genus Solidago (Ⅰ) : On the Leaves of the genus Solidago
Ki-Hwan Bae(배기환),Beong-Tae Yoo(유병태),Chang-Soo Yook(육창수) 한국생약학회 1982 생약학회지 Vol.13 No.3
The internal structure and surface view of the leaves of the genus Solidago have been clarified. A key based on the anatomical features has been constructed.
배기환(Ki Hwan Bae),서원준(Won Jun Seo) 대한약학회 1994 약학회지 Vol.38 No.1
7,8-Dioxo-A-norerythrinan (A) was synthesized from acid catalyzed cyclization of 6a-hydroxy-1-(2-phenylethyl)-octahydrocyclo-penta[b]pyrrole-3a-carboxylic acid ethyl ester (B) with concomitant deethoxycarbonylation. The intermediate (B) was a hydroxylated compound of N-acyliminium (C). The unstable pyrrolinium (C) was prepared from oxalylation of the enamine of phenethylamine and ethyl 2-oxocyclopentanecarboxylate.
배기환(Ki Hwan Bae),김영호(Young Ho Kim),원도희(Do Hee Won),이준성(Jun Sung Lee),강종성(Jong Seong Kang) 대한약학회 1997 약학회지 Vol.41 No.4
Magnolol and honokiol, the main components of Magnoliae Cortex, were isolated and used as the standard substances for the analysis. In order to determine the contents of magnolol and honokiol in Magnoliae Cortex originated from Korea, China and Japan, both HPLC and HPTLC methods are applied and compared with each other. The components were separated on C8 column with acetonitrile-water-acetic acid (50:50:1) in HPLC and detected at UV 294nm. The components separated on HPTLC precoated silica gel plate with chloroform-methanol (9:1) were detected directly on the plate at 254nm. The contents of magnolol and honokiol in Magnoliae Cortex were in the wide range of 0.01~2.8% and 0.005~0.8%, respectively, according to their purchase places. It is also applicable to the quality control of various preparation from Magnoliae Cortex.
배기환(Ki Hwan Bae),민병선(Byung Sun Min),백흠영(Hum Young Baek),안병준(Byung Zun Ahn) 大韓藥學會 1991 약학회지 Vol.35 No.4
The extractability and stability of ginkgoflavonolglycosides under presence of several cellulose preparations were investigated. The enzymes used were macerosin, cellulose C and cellulase NC. The content variation of the glycosides was measured with HPLC method, using caffeic acid as an internal standard. The methanol extract of ginkgo leaf, containing the total flavonolglycosides of 4.46%, was used for the content comparison. By extraction with the enzymes, each or mixed, the peak levels of all the glycosides began to decrease after 1 or 2 hours. After 24 hour extraction, most of the glycosides were degraded to minor components. The flavonolglycosides in ginkgo leaf were also hydrolysed simply by the water extraction. After 24 hour extraction with water at 40oC, the peak levels of major glycosides were distinctly decreased. Rutin was hydrolysed by enzyme treatment or by ginkgo leaf itself. As a result, it was concluded that the commercially available cellulases and the ginkgo leaf itself contain the activities of beta-glycosidase and alpha-rhamnosidase. Kaempferol-3-0-(6''-O-p-coumaroylglucosyl)-rhamnoside and four other ginkgo flavonolglycosides were not hydrolysed under the same condition.
Hyroxybiphenyl 유도체의 항균작용 (III) 충치균 Streptococcus mutans에 대한 p-Phenylphenol 유도체의 항균작용
배기환(Ki Hwan Bae),서원준(Won Jun Seo),박종태(Jong Tae Park) 대한약학회 1991 약학회지 Vol.35 No.1
For the purpose of developing of anticariogenic agents, p-phenylphenol derivatives were synthesized and determined their antibacterial activities against a cariogenic bacterium, Streptococcus mutans. Among synthetic compounds, 2-nitro-6-bromo-p-phenylphenol showed as potent antibacterial activity as magnolol and honokiol.
4,4''-Biphenol 유도체의 합성 및 충치균 Streptococcus mutans OMZ 176에 대한 항균작용
배기환(Ki Hwan Bae),서원준(Won Jun Seo),임승희(Seung Hee Leem) 대한약학회 1992 약학회지 Vol.36 No.1
In a continuous study for the developing of the anticariogenic agents, 3,3''-diacyl-4,4''-biphenol derivatives (Fig.2, 2 and 3) and 3,3''-bis-(1-hydroxyalkyl)-4,4''-biphenol (Fig. 3, 4 and 5) derivatives are synthesized successively from 4,4''-diphenol (Fig. 2, 1). The synthesized compounds are tested for their antibacterial activity against a cariogenic bacterium, Streptococcus mutans OMZ 176. The acyl derivatives, 2 and 3, do not show antibacterial activity, but the hydroxyallkyl derivatives, 4,and 5, reduced form the acyl group of 2 and 3, show the activity The antibacterial activity of 2 and 3 may be inhibited due to intramolecular hydrogen bonding between the acyl group and the hydroxyl one (Fig.4).
배기환(Ki Hwan Bae),이상명(Sang Myung Lee),이은실(Eun Sil Lee),이준성(Jun Sung Lee),강종성(Jong Seong Kang) 대한약학회 1996 약학회지 Vol.40 No.5
Betulinic acid and alphitolic acid, the triterpenoids of Zyziphi Fructus, were isolated with silica gel column chromatography and used as the standard substances for the analysis. The compounds were determined with HPLC and HPTLC. They were separated on reversed phase column (Nova-Pak C18) with 0.05M Na2HPO4-methanol (19:81) in HPLC and detected at 210nm. Separation on HPTLC precoated silica gel F254 plates was carried out with chloroform-methanol (6:1) and the separated compounds were reacted with p-anisaldehyde and detected at 540nm. The contents of betulinic acid and alphitolic acid in Zyziphi Fructus from four different regions in Korea were in the range of 2.9~3.8% and 3.2~3.9%, respectively.
배기환(Ki Hwan Bae),김환묵(Hwan Mook Kim),이상명(Sang Myung Lee) 대한약학회 1996 약학회지 Vol.40 No.2
The cytotoixic effect of Pylorae Herba (Pyrola japonica Klenze) against L1210 and K-562 cells was studied in vitro. The methanolic extract of Pylorae Radix was added to the culture of L1210 cells and K-562 cells for the cytotoxic activity and the ED50 values of hexane, ethylacetate, buthanol and water fractions from methanolic extract were determined using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) assay. The active constituent isolated by bioassay guided fractionation followed by purification gave rise to a yellow needle crystal and was clarified to be chimaphilline by the comparison with the published data. The average life spans with it were not prolonged significantly on tumor growth in hybrid female mouse (BDF1-KIST) inoculated subcutaneously with P388 cells.