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Brown Guinea Pig와 Hairless Mouse를 이용한 광노화 모델에서 LGNC-5의 경구반복투여에 의한 피부주름발생 및 색소침착억제 효과
노경옥(Kyong-Ok No),조호성(Ho-Song Cho),박상기(Sang-Ki Park),이헌식(Heon-Sik Lee),장민열(Min-Youl Chang),이민호(Min-Ho Lee),강상진(Sangjin Kang),조완구(Wan-Goo Cho),박혜지(Hye Ji Park),홍진태(Jin Tae Hong) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4
비타민과 불포화지방산, 그리고 폴리페놀의 복합처방인 LGNC-5 (LG생활건강 기술연구원 개발)가 건강기능식품의 개별인증을 받을 수 있는지의 여부를 확인하기 위해 hairless mice와 brown guinea pig 모델을 이용해 자외선에 의한 주름생성 및 색소침착 억제력 평가를 실시하여 다음과 같은 결괴를 얻었다. 1. Hairless mice를 대상으로 실시한 주름억제실험에서 육안관찰과 피부주형의 영상분석결과, LGNC-5군은 농도의존적인 주름발생 억제효과를 보였으며, 고용량군(x60)인 LGNC-5H군의 경우 10주후 정상군과 유사한 수준의 양호한 피부 상태를 보였다. Hematoxylin & Eosin stain 에서도 LGNC-5H군에서는 UV 대조군에 비해 표피 두께와 과각화가 현저하게 줄어드는 것으로 조사되어 우수한 주름발생억제 효과를 확인하였다. 2. Brown guinea pig을 대상으로 실시한 색소침착억제력 실험에서 육안관찰과 색차계를 이용한 측정결과, LGNC-5H군에서는 설험개시 7일 후부터 UV 대조군에 비해 색소침착이 억제되기 시작해, 설험 종료시까지 색소침착억제효과를 보였다(p<0.05). Fontana-masson silver stain 에서도 LGNC-5H군에서는 UV 대조군에 비해 melanin 침챡량이 현저하게 감소된 것으로 조사되어 LGNC-5H의 색소침착억제효과를 확인하였다. 3. 10주간의 주름억제실험과 4주간의 색소침착 억제실험에 사용한 모든 설험동물에서 사망 혹은 시험물질 투여로 인한 특이한 임상증상이 관찰되지 않았다. 시험물질 투여 기간 중 사료와 음수 소비량 역시 유의한 변화를 관찰할 수 없었으며, 대조군과 실험군 모두 정상적인 체중 증가를 나타내었다. 이상의 실험결과를 종합하면 LGNC-5은 안전하고 경구반복투여 시 UV조사로 인해 hairless mice에서 발생되는 주름과 brown guinea pig에서 생성되는 색소침착을 효과적으로 억제시키는 처방인 것으로 평가되었다. Chronic exposure of UV radiation in sunlight results in a number of biological responses, including erythema, sunburn cell formation, immune suppression, photoaging, and skin cancer. In this study, we investigated the effects of LGNC-5 (LG Nutricosmetics-5, the mixture of vitamins, unsaturated fatty acid and polyphenol) on UV-induced skin damage. Oral administration of LGNC-5 for 10 weeks resulted in inhibition of UVB-induced wrinkle formation in SKH-1 hairless mice skin compared to UV control group as a dose dependent manner. LGNC-5 treatment also inhibited UV radiation-induced skin pigmentation in brown guinea pigs examined by colorimeter and Fontana-masson silver staining. These results mean that LGNC-5 as a dietary supplement could be useful to attenuate solar UVB-induced melanogenesis and premature skin aging.
최재우 ( Jae-woo Choi ),장성인 ( Sung-in Jang ),장석용 ( Suk-yong Jang ),김승주 ( Seung-ju Kim ),박혜기 ( Hye-ki Park ),김태현 ( Tae Hyun Kim ),박은철 ( Eun-cheol Park ) 한국보건행정학회 2016 보건행정학회지 Vol.26 No.2
Background: The voluntary diagnosis-related groups (DRG)-based payment system was introduced in 2002 and the government mandated participation in the DRG for all hospitals from July 2013. The main purpose of this study is to examine the independent effect of mandatory participation in DRG on various outcomes of patients. Methods: This study collected 1,809,948 inpatient DRG data from the Health Insurance Review and Assessment database which contains medical information for all patients for the period 2007 to 2014 and examined patient outcomes such as length of stay (LOS), total medical cost, spillover, and readmission rate according to hospital size. Results: LOS of patients decreased after DRGs (large hospitals: adjusted odds ratio [aOR], 0.87; 95% confidence interval [CI], 0.78-0.97; small hospitals: aOR, 0.91; 95% CI, 0.91-0.92). The total medical cost of patients increased after DRGs (large hospitals: aOR, 1.22; 95% CI, 1.14-1.30; small hospitals: aOR, 1.22; 95% CI, 1.21-1.23). The results reveals that spillover of patients increased after DRGs (large hospitals: aOR, 1.27; 95% CI, 0.70-2.33; small hospitals: aOR, 1.18; 95% CI, 1.16-1.20). Finally, we found that readmission rates of patients decreased significantly after DRGs (large hospitals: aOR, 0.28; 95% CI, 0.26-0.29; small hospitals: aOR, 0.59; 95% CI, 0.56-0.63). Conclusion: The DRG payment system compared to fee-for-service payment in South Korea may be an alternative medical price policy which can reduce the LOS. However, government need to monitor inappropriate changes such as spillover increase. Since this study also is the results based on relatively simple surgery, insurer needs to compare or review bundled payment like new DRG for expansion of various inpatient-related diseases including internal medicine.
Bisphenol A에 의한 신경계 세포의 칼슘 항상성 교란 및 세포독성에 미치는 영향
이윷모(Yoot Mo Lee),이상민(Sang Min Lee),손동주(Dong Ju Son),이선영(Sun Young Lee),박혜지(Hye Ji Park),남상윤(Sang Yun Nam),김대중(Dae Joong Kim),윤영원(Young Won Yun),유환수(Hwan Soo Yoo),오기완(Ki Wan Oh),김태성(Tae Seong Kim),한순영( 한국독성학회 2004 Toxicological Research Vol.20 No.3
We previously found that bisphenol A (BPA) caused neurotoxic behavioral alteration.<br/> Since disturbance of calcium homeostasis is an implicated contributor in the neurotoxic mechanism of<br/> environmental toxicants, we investigated whether BPA alters calcium homeostasis. Unlike other neurotoxic<br/> agents which cause increase of intracellular calcium level, BPA decreased [Ca2+]i dose-dependently<br/> in PC12 cells and cortical neuronal cells regardless of the calcium existence in buffer. BPA at<br/> greater concentrations than 100 μM reduced cell viability significantly in both types of cells. BPA also<br/> suppressed L-glutamate (L-type channel activator, 30 mM) and trifluoperazine (calmodulin antagonist,<br/> 30 μM)-induced increase of [Ca2+]i. BPA further lowered caffeine (RYR activator, 100 μM)-decreased<br/> [Ca2+]i, but did not alter dantrolene (RYR inhibitor, 100 μM), heparin (IP3 inhibitor, 200 units/ml) and<br/> xestospongin C (IP3 inhibitor, 5 μM)-decreased [Ca2+]i. Cell viability was not directly related to intracellular<br/> calcium change by bisphenol A that alternation of intracellular calcium may not be a direct causal<br/> factor of BPA-induced neuronal cell death.