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박주흥,최아정,김수지,정소연 대한면역학회 2015 Immune Network Vol.15 No.6
The intestinal immune system maintains oral tolerance to harmless antigens or nutrients. One mechanism of oral tolerance is mediated by regulatory T cell (Treg)s, of which differentiation is regulated by a subset of dendritic cell (DC)s, primarily CD103+ DCs. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, plays an important role in regulating immunity. The intestines are exposed to various AhR ligands, including endogenous metabolites and phytochemicals. It was previously reported that AhR activation induced tolerogenic DCs in mice or in cultures of bone marrow-derived DCs. However, given the variety of tolerogenic DCs, which type of tolerogenic DCs is regulated by AhR remains unknown. In this study, we found that AhR ligand 3,3'-diindolylmethane (DIM) inhibited the development of CD103+ DCs from mouse bone marrow cells stimulated with Flt3L and GM-CSF. DIM interfered with phosphorylation of STAT3 and STAT5 inhibiting the expression of genes, including Id2, E2-2, IDO-1, and Aldh1a2, which are associated with DC differentiation and functions. Finally, DIM suppressed the ability of CD103+ DCs to induce Foxp3+ Tregs.
Hypertonicity Induction of Melanoma Antigen, a Tumor-associated Antigen
박주흥,Soo-Woong Lee 한국분자세포생물학회 2002 Molecules and cells Vol.13 No.2
Melanoma antigen (MAGE), a tumor-associated antigen, is a product of members of a gene family that consist of 24 structurally related genes. MAGE genes are expressed only in the testis among normal tissues, but they are also expressed in a number of human tumors of various histological types. Although the MAGE expression is primarily regulated by the genome- wide demethylation of CpG dinucleotides, the demethylation of CpG dinucleotides does not always result in the MAGE expression. In the present study, we demonstrated that 40 mM NaCl induces the transcriptional and translational activation of MAGE-B1 and -B2 in specific tissues. The mRNA stability analyses revealed that the half-life of the MAGE-B1 mRNA is about 5 h. No change in the stability of the MAGEB1 mRNA was induced by the NaCl treatment, which suggests the transcriptional activation of MAGE-B1 by NaCl. This is the first report that the MAGE expression is regulated by means other than the genomewide demethylation of CpG dinucleotides.
MAGE-1 단백질의 생산과 anti-MAGE-1 polyclonal 항체의 생성
이정희,박주흥 Institute of Genetic Engineering Changwon National 1999 Gene and Protein Vol.3 No.1
MAGE-1, which was originally identified by reacting with cytolytic T lymphocytes derived from the blood of melanoma patients, is a member of a gene family consisting of twelve structually and expressionally related genes, called MAGE-1 to 12 located in the Xq28 region. The MAGE genes are expressed only in testis among normal tissues and in a variety of tumors. However, what biological functions it has is currently unknown. In the present study we have tried to develop antibodies against MAGE-1 protein to better understand biological functions of MAGE-l. We cloned the MAGE-1 cDNA into an Escherichia coli expression vector and were able to produce Ni-NTA resin-purified recombinant MAGE-1 protein of 46 kDa on SDS/PAGE which was subsequently used for immunizing mice. Sera collected from immunized mice were shown to specifically react with MAGE-1 antigen by ELISA in combination with Western blotting. This polyclonal anti-MAGE serum will be used for functional studies of MAGE Protein.
Direct Antigen Presentation by Tumor cells to T cells
Park,Joo-Hung 昌原大學校 基礎科學硏究所 1998 基礎科學硏究所論文集 Vol.10 No.-
Interleukin 12를 발현하는 M-MSV-BALB/3T3 암세포백신에 의하여 유도되는 강한 세포서면역반응은 암세포백신의 전처리(mitomycin C의 처리나 초음파로 분쇄)에 의하여 억제된다. 한편, interleukin 12의 면역증강효과는 세포표면의 제 1 주조직접합체(Major Histocompatibility Complex Class Ⅰ)분자의 발현이 낮은 암세포(MCA-102)백신의 경우 효력을 상실하지만, 외부에서 공급된 제 1 주조직접합체(Major Histocompatibility Complex Class Ⅰ)분자의 발현에 의하여 효력을 찾게된다. 이러한 사실들은 암세포자체가 직접적으로 항원을 T세포에 표출한다는 것을 암시한다.