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열처리한 자가혈청이 성인 골수간엽줄기세포의 증식과 조골세포 분화에 미치는 영향
박의균 ( Eui Kyun Park ),이선영 ( Sun Young Lee ),김태호 ( Tae Ho Kim ),정필훈 ( Phil Hoon Choung ),강길선 ( Gil Son Khang ),손영숙 ( Young Sook Son ),김석영 ( Suk Young Kim ),김신윤 ( Shin Yoon Kim ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.1
Tissue engineering using mesenchymal stem cells (MSCs) is a promising technology for treatment or regeneration of tissue defects. However, to put this technology into practical use, it is necessary to determine suitable biomaterials as well as to expand MSCs ex vivo. One major challenge of ex vivo expansion of MSCs is to avoid the use of fetal bovine serum (FBS), which is a fundamental culture supplement. In this study, we investigated effects of autologous serum on proliferation and osteoblastic differentiation of bone marrow stem cells (BMSCs) isolated from patients with skeletal diseases. We isolated BMSCs from 7 independent patients with avasular necrosis (AVN; 3 cases), osteoarthritis (OA; 2 cases), femoral head fracture (1 case) or hip dysplasia (1 case) and compared the effects of FBS, heat inactivated (HAS) and normal autologous serum (HA) on the proliferation of BMSCs. Proliferation analyses of BMSCs revealed that 5 out of 7 BMSCs cultured in 10 % HAS showed higher proliferation than cells cultured in 10 % FBS. Moreover, analysis of osteoblastic differentiation as assessed by alkaline phosphatase (ALP) staining, a marker for osteoblastic differentiation, showed that HAS, AS and FBS were capable of supporting osteoblastic differentiation of BMSCs at the similar level. Interestingly, mineralization was increased in BMSCs cultured in HAS (5 out of 6 BMSCs). These results demonstrate that HAS compared with conventional FBS has a better potential to stimulate proliferation and mineralization of BMSCs as well as to support their osteoblastic differentiation.
연구논문 : 의약화학 ; MAP kinase 활성화와 액틴 환 형성을 통하여 RANKL 유도된 파골세포 분화와 기능을 억제하는 엘라지탄닌, 후로신
박의균 ( Eui Kyun Park ),김명선 ( Myung Sunny Kim ),이승호 ( Seung Ho Lee ),김경희 ( Kyung Hee Kim ),박주영 ( Ju Young Park ),김태호 ( Tae Ho Kim ),이인선 ( In Seon Lee ),우제태 ( Je Tae Woo ),정재창 ( Jae Chang Jung ),신홍인 ( Ho 영남대학교 약품개발연구소 2005 영남대학교 약품개발연구소 연구업적집 Vol.15 No.-
손정오 ( Jung Oh Sohn ),박의균 ( Eui Kyun Park ),이진호 ( Jin Ho Lee ),신홍인 ( Hong In Shin ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.1s
Bone defects occur in a variety of clinical situation, and their reconstruction to provide mechanical integrity to the skeleton is a necessary step in the patient rehabilitation. Bones can regenerate themselves to repair defects up to a certain size but sometimes the suitable implant materials have to be applied to facilitate the bone repair. As a part of the effort to improve the efficiency of bone repair, we evaluated the hydrophilized asymmetric pore sized polydioxanone membrane for guided bone regeneration. The polydioxanone membrane was fabricated to have different pore size at inner (around 50 nm in diameter) and outer surface (around 50 μm in diameter) with an average 0.4 mm thickness. The cytotoxic effect of it was analyzed in vitro and the histocompatibility and guided bone regeneration effects were evaluated in vivo, respectively. The rat tibia bone defects measuring 7 mm×3 mm in size were treated with polydioxanone membrane with or without application of 10 mM LiCl or 100 μg/ml T-CAM. The defects were evaluated at 3weeks after treatment by radiography and histology. The polydioxanone membrane was relatively resilient with some cushion. It was no cytotoxic and evoked neither an immune nor an inflammatory response. It was gradually absorbed by numerous multinucleated giant cells with time and completely disappeared within 8 weeks at rat subcutaneous pouches. The application of polydioxanone membrane at rat tibia bone defects induced more effective bone repair with matured cortical plate regeneration compared to none membrane applied group. In addition, the treatment of 10 mM LiCl and 100 μg/ml T-CAM within polydioxanone membrane facilitated bony healing. These results suggest that the combined application of bioactive molecules such as 10 mM LiCl or 100 μg/ml T-CAM with hydrophilized sized polydioxanone membrane can facilitate the guided bone regeneration.
정밀 다축 적층 장치를 이용한 Blended PCL/PLGA/TCP 인공지지체 제작
김종영(Jong Young Kim),박의균(Eui Kyun Park),김신윤(Shin-Yoon Kim),조동우(Dong-Woo Cho) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
Recent developments in tissue-engineering techniques allow physicians to treat a range of previously untreatable conditions. In the development of such techniques, scaffolds with a controllable pore size and porosity have been manufactured using solid free-form fabrication (SFF) methods to investigate cell interaction effects such as cell proliferation and differentiation. In this study, we describe the fabrication of scaffolds from two types of biodegradable materials using a precision deposition system that we developed. The precision deposition system uses technology that enables the manufacture of three-dimensional microstructures. Fabrication of 3D tissue engineering scaffolds using the precision deposition system required the combination of several technologies, including motion control, thermal control, pneumatic control, CAD/CAM software. Through the fabrication of two kinds of scaffolds using poly-caprolactone (PCL), poly-lactic-co-glycolic acid (PLGA) and tri-calcium phosphate (TCP), feasibility of the tissue engineering of developed SFF based precision deposition system is demonstrated.