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WHW(R)의 랫드에서의 반복경구투여 독성에 관한 연구
박용기 ( Yong Ki Park ),오태우 ( Tae Woo Oh ),배효상 ( Hyo Sang Bae ),윤철호 ( Cheol Ho Yoon ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.3
Objectives: We investigated the repeated-dose toxicity of Wenpitang-Hab-Wulingsan(WHW), a Korean traditional medicine prescribed with twelve herbs, which has been used for the treatment of renal disease. Methods: WHW extract prepared by GLP company. WHW was supplemented by gavage at 0, 100, 500 and 1000㎎/㎏/day for 13-week consecutive days. We recorded the clinical signs of toxicity, body weight, organ weights, hematology, gross and histological changes in target organs rats and clinical chemistry analysis for all rats. Results: WHW extract at all doses was shown no mortality or abnormal clinical signs in rats during at the observation period. Furthermore, there was no difference in body weight and food-take consumption, organ weight, gross pathological findings, and urine analysis among the groups of rats treated with different doses of WHW extract. The hematological analysis and clinical blood chemistry data were revealed no toxic effects from WHW-treated rats. Conclusions: The results suggest that WHW extract in rats is a wide margin of safety on a acute toxicity.