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원발성 중추신경계 림프종의 치료 성적에 대한 다기관 후향적 분석
문준호 ( Joon Ho Moon ),김동환 ( Dong hwan Kim ),안병민 ( Byung Min Ahn ),김시내 ( Shi Nae Kim ),전석봉 ( Seok Bong Jeon ),백진호 ( Jin Ho Baek ),김종광 ( Jong Gwang Kim ),손상균 ( Sang Kyun Sohn ),이규보 ( Kyu Bo Lee ),황정현 ( J 대한내과학회 2006 대한내과학회지 Vol.71 No.6
Background: A primary central nervous system lymphoma (PCNSL) is a rare neoplasm with a poor prognosis. The treatment of PCNSL involves a combination of chemotherapy, intrathecal chemotherapy and radiotherapy. This study retrospectively evaluated the treatment outcomes and prognostic factors of Korean patients with PCNSL. Methods: Between 1995 and 2003, 58 patients diagnosed with PCNSL from the multi-center hospitals were enrol1ed in this study. Among 56 patients who had received treatment, 16 patients were treated with radiotherapy alone, while 40 patients were treated with combined chemotherapy (CHOP; 9 cases, high-dose methotrexate; 31 cases) and radiotherapy. Results: The median age of the patients was 58 years (range, 19-76). A diffuse large B-cell lymphoma was diagnosed in 56 cases (96.6%), while a peripheral T-cell lymphoma was diagnosed in 2 cases. Of the 47 patients who could be assessed for their response after treatment, a CR and PR was observed in 32 (68%) and 11 patients (23%), respectively, giving an overall response rate of 91% (95% CI, 82~100%). The estimated 3-year overall survival rate for all the patients was 67±7.9% and the 3-year disease free survival rate was 53±8.3%. The overall survival of the high-dose methotrexate group was superior to that of the CHOP group (77±10%) versus 47±19%, p=0.05). Leukoencephalopathy was observed as a late complication in 9 patients (21%). No significant prognostic factors affecting survival were found by univariate analysis. Conclusions: Approximately half of the patients could have long-term survival after treatment in this study. High-dose methotrexate containing chemotherapy followed by radiotherapy was found to be an effective treatment. (Korean J Med 71:65i4-661, 2000)
문준호 ( Joon Ho Moon ),박철희 ( Cheol Hee Park ),정재원 ( Jae One Jung ),신운건 ( Woon Geon Shin ),김종표 ( Jong Pyo Kim ),김경오 ( Kyoung Oh Kim ),한태호 ( Tae Ho Hahn ),유교상 ( Kyo Sang Yoo ),박상훈 ( Sang Hoon Park ),김종혁 ( 대한소화기학회 2006 대한소화기학회지 Vol.48 No.2
Colon cancer is the most serious intestinal complication in patients with Crohn`s disease. Although an association between Crohn`s disease and colon cancer has not been clearly defined, a number of studies in western countries reported an increased rate of colon cancer in patients with Crohn`s disease. In Korea, Crohn`s disease is rare when compared to western countries, and only a single case of colon cancer associated with Crohn`s disease has been reported. We recently experienced a 66-year-old women with colon cancer associated with Crohn`s disease. (Korean J Gastroenterol 2006;48:124-127)
비알코올 지방간에서 혈중 철 표지자 및 간내 철 농도와 간 손상의 연관성
문준호 ( Joon Ho Moon ),박상훈 ( Sang Hoon Park ),오길찬 ( Kil Chan Oh ),정재원 ( Jae One Jung ),신운건 ( Woon Geon Shin ),김종표 ( Jong Pyo Kim ),김경오 ( Kyoung Oh Kim ),박철희 ( Cheol Hee Park ),한태호 ( Tae Ho Hahn ),유교상 ( 대한소화기학회 2006 대한소화기학회지 Vol.47 No.6
목적: 비알코올 지방간질환(nonalcoholic fatty liver disease, NAFLD)은 비알코올 지방간, 비알코올 지방간염(nonalco-holic steatohepatitis, NASH), 원인미상 간경변증과 간부전 등으로 진행되며, 드물게는 원인미상 간세포암으로 진행할 수 있다. 그러나 아직까지 비알코올 지방간에서 NASH로 진행하는 기전이 명확하지 않으며 조직 검사 이외에 비침습적인 방법으로 NASH 또는 섬유화의 진행을 예측할 수 있는 방법도 없다. 간내 철은 다양한 과정을 통해 간세포의 손상을 일으킬 수 있으며 많은 만성 간질환에서 섬유화의 원인으로 밝혀져 있다. 최근 NAFLD 환자에서도 증가된 간내 철이 간의 염증 및 섬유화를 초래하고 NASH로의 진행에 관여한다는 연구들이 있었다. 이번 연구는 혈중 철 표지자, 간내 철농도와 간조직 소견을 비교하여 NAFLD 환자에서 간내 혹은 혈중 증가된 철이 NASH의 발생 과정과 관련이 있는지 알아보고, 철의 농도에 따라 NASH 발생을 예측할 수 있는지를 알아보고자 하였다. 대상 및 방법: 2001년 7월부터2005년 7월까지 본원에서 간조직 검사에 의해 NAFLD로 진단된 환자 39예를 대상으로 하였다. 39예에서 체내 철분 표지자를 측정하였고, 이 중 29예에서 간내 철 농도를 측정하였다. 간조직 소견은 modified Brunt법을 이용하여 지방증, 염증, 섬유화 정도를 분류하였다. 혈중 철분 표지자와 간내철 농도가 염증 또는 섬유화와 상관관계가 있는지와 예측인자인지 알아보기 위해 통계분석을 하였다. 결과: 혈중 철표지자 및 간내 철 농도 모두 염증 및 섬유화와 상관관계가 없었다. 혈중 철 표지자 중 혈청 페리틴은 염증 및 섬유화 정도와 상관관계를 보이면서 증가된 소견을 보였고 단변량 분석에서 통계적으로 의미 있는 결과를 보였다(p=0.008). 그러나 다변량 분석에서는 통계적으로 의미가 없었다. 결론: NAFLD 환자에서 간내 철 농도는 염증과 섬유화 등의 조직손상의 심한 정도와 관계가 없으며 단순지방간에서 NASH의 발생을 추측할 수 있는 예측인자도 아닌 것으로 보이나, 추후보다 환자를 대상으로 한 많은 연구가 필요하다고 생각한다. BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty Liver and progress to severe Liver disease such as cirrhosis. The mechanism determining the progression from fatty Liver to steatohepatitis is unknown. Iron is suspected to enhance hepatic damage associated with nonalcoholic fatty Liver disease (NAFLD). The aims of this study were to evaluate the relationship of serum iron indices and hepatic iron deposition with hepatic fibrosis or inflammation, and to assess whether the increased hepatic iron deposition is an independent predictor of progression to Liver injury. METHODS: The biochemical and histopathological data of thirty-nine patients with NAFLD were analyzed. Liver biopsy findings were graded according to the method described by Brunt, et al. Hepatic iron concentration was available in 29 of 39 patients. RESULTS: The mean hepatic iron concentration and hepatic iron indices were 1,349+/-1,188mulg/g dry weight and 0.9+/-0.7mulg/g/age. Serum ferritin and body mass indices were associated with hepatic inflammation (p=0.001, p=0.006) and fibrosis (p=0.005, p=0.013). Hepatic iron concentration and hepatic iron index were not associated with hepatic inflammation and fibrosis. Multivariate analysis did not identify serum ferritin or body mass index as an independent predictor of Liver injury. CONCLUSIONS: Hepatic iron deposition shows no association with the degree of hepatic inflammation or fibrosis. Hepatic iron is not an independent predictor of hepatic injury in patients with NAFLD. (Korean J Gastroenterol 2006;47:432-439)
문준호 ( Joon Ho Moon ),서영일 ( Young Il Seo ),김현아 ( Hyun Ah Kim ),홍지현 ( Ji Hyun Hong ),전강 ( Gang Jeon ),하준욱 ( Jun Wook Ha ),이승순 ( Seung Soon Lee ),정재원 ( Jae One Jung ),박충기 ( Choong Kee Park ),박혜림 ( He Lim 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Scleroderma is rare disease of unknown etiology characterized by fibrosis of skin and internal organs such as lung, gastrointestinal tract, kidney, heart and so on. The association between scleroderma and malignancy has been a controversy during recent years. We report a 77-year old female who had scleroderma and squamous cell carcinoma of esophagus. She was diagnosed as esophageal carcinoma and then sclerotic skin change developed in both hands and feet 3 months later. We present this case with a review of literatures.