실버타운 선호도에 영향을 주는 요인에 관한 연구

문자 한국농촌간호학회 2007 한국농촌간호학회지 Vol.2 No.2

본 연구의 목적은 앞으로 실버타운 이용 가능성이 높 은 중년층을 대상으로 노후생활에 대한 인식정도, 실버 타운에 대한 인지도, 실버타운에서 제공되는 서비스에 따라 선호도를 분석함으로써 저비용, 고효율의 차별화된 실버타운 개발에 기초 자료를 제공함을 목적으로 하고 있다.

Diazepam정제의 함량균일성 및 용출성평가

문자,박재영,최인,문홍섭,최준식 한국병원약사회 1994 병원약사회지 Vol.11 No.1

Drug effect depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of preparations for drug choice among preparations by dissolution test and content uniformity test of commercial diazepam tablets. Diazepam is benzodiazepines and has sedative action. The dissolution test was conducted in artificial gastric juice and artificial intestinal juice using Basket method with four diazepam preparations (A, B, C, D) which were pharmaceutically equivalent. The results were as following: 1) The dissolution rate in artificial gastric juice was higher in the order of four different brands D>A>B>C. 2) The dissolution rate in artificial intestinal juice was higher in the order of four different brands B>A>C>D. 3) Content uniformity of four different brands was better in such order as D>B>C>A. The relationship between each results was not established.

보건진료소장의 고혈압/당뇨 환자관리 경험

문자 한국농촌간호학회 2018 한국농촌간호학회 학술대회지 Vol.- No.1

신 기후평년값 기준 우리나라 극한기온의 변화경향

문자연,김기영 건국대학교 기후연구소 2021 기후연구 Vol.16 No.2

The present study aims to analyze climate change and trend of extreme temperature events occurred over the Republic of Korea. The observation data used are daily average, maximum, and minimum temperature from 6 weather stations for the period of 1912-2020. Seven extreme indices regarding frequency and extreme value of temperature are calculated in seasonal and annual time range. In addition, hot extremes and their changes by four physical terms that include information on the annual mean temperature, the amplitude of the annual cycle, the diurnal temperature range and the local temperature anomaly on the day of the extreme are analyzed. The climatology for the analysis is updated to the new normal year of 1991-2020. Consistent with the previous findings, statistically significant change was detected in the indices of annual lowest daily minimum temperature, annual extreme temperature range, frequency of daily minimum temperature below -12℃ and 10%ile(TN10p) during winter. Due to the gradual decrease of the occurrence days regarding the extreme minimum temperature during winter, the frequency calculated by the relative threshold in extreme high temperature during summer prevail since 1990s. Indices related with extreme high temperature had larger low-frequency variability than significant climate change during the analysis period. However, the assessment of hot extremes according to the terms describing mean, variability and tails during the new normal year of 1991-2020, significant increasing trend was detected not only in the annual mean and the amplitude of the seasonal cycle, but also in the daily hot extreme anomaly.

종관 및 대규모 순환과 관련된 우리나라 여름철 극한강수 특성 연구

문자연,최영은,김유진,김민기 건국대학교 기후연구소 2015 기후연구 Vol.10 No.4

In this study, we analyzed the characteristics of summer extreme rainfall over South Korea and their relationships with the synoptic and large-scale circulation anomalies during 1979-2014. Heavy rainfall (R90p) is related with the strong convection surrounded by dry zone over Korean peninsula and the moist air delivered from the convection area over Bay of Bengal-South China Sea-Philippine Sea. The upper-level anticyclonic flow with the low-level dipole of anticyclonic circulation in the Southeast and cyclonic circulation to the northwest of Korean peninsula are the main characteristics when the extreme rainfall occurs. The barotropic Rossby wave developed over the Korean peninsula transfers its energy farther downstream to the western coast of North America. It is also found that the dominant lowfrequency oscillation over the tropics (intraseasonal oscillation) play an important background role for the enhancement of extreme rainfall over South Korea.

뇌전증 소아들에서 주의력결핍과잉행동장애와 뇌 MRI 소견의 연관성

문자운(Ja Un Moon),윤다혜(Da Hye Yoon),박선영(Sun Young Park),임수아(Soo Ah Im),이인구(In Goo Lee) 대한소아신경학회 2018 대한소아신경학회지 Vol.26 No.2

목적: 뇌전증 소아들 중 주의력 결핍 과잉행동장애가 중복된 소아들의 뇌 MRI를 분석하여 ADHD와 뇌 MRI의 연관성을 알아 보고, MRI 의 이상 소견이 ADHD 발생의 위험인자가 될 수 있는지의 여부를 알아보고자 하였다. 방법: 2009년 3월부터 2013년 12월까지 가톨릭대학교 서울성모병원 소아신경과에서 뇌전증을 진단 받고, 항경련제 치료를 받는 6세에서 18세까지의 환자들 중 ADHD 가 중복 되었고 최소 1년 이상 추적 관찰이 가능하였던 55명(남자 36명, 여자 19명)의 소아들을 대상으로 하였다. ADHD의 진단은 정신질환 진단 및 통계편람 (DSM-IV, Diagnostic and Statistical Manual of Mental Disorder, 4thedition)의 기준에 따라 진단하였다. 결과: 뇌 MRI가 정상 소견을 보인 환자들은 대부분 주의력결핍형의 ADHD였으나(28명, 96.5%), 뇌 MRI가 비정상 소견을 보인 환자들은 혼합형이 14명(53.8%)으로 가장 많았으며, 주의력결핍형이 12명(46.2%)으로 MRI이상소견의 유무에 따라 ADHD의 아형에 차이가 있었다. 또한 주의력결핍 및 과잉행동-충동에 관한 각각의 문항 9개 중 양성을 보인 개수를 MRI 소견의 이상유무에 따라 비교한 결과, MRI소견에서 이상이 있는 환자군에서 ADHD 증상이 심한 것으로 평가되었다. 결론: 뇌전증 소아 환자들에서 MRI 이상 소견은 ADHD와 밀접한 연관성을 가지고 있을 뿐 아니라 ADHD 의 중증도와 연관될 수 있음을 말해준다. 따라서 MRI에 이상 소견이 발견되는 뇌전증 환자에서는 조기 ADHD 선별검사를 시행해 이에 대한 대책을 수립하는 것이 치료 및 삶의 질 향상에 도움이 될 것이라고 여겨진다. Purpose: We analyze the brain magnetic resonance imaging (MRI) findings of children with epilepsy and concomitant attention deficit hyperactivity disorder (ADHD) to investigate the correlation between brain MRI and ADHD, and to determine whether abnormal MRI finding can be a risk factor for the development of ADHD. Methods: A total of 55 patients (36 male, 19 female) were diagnosed as ADHD in children with epilepsy at the pediatric neurology department of Seoul St. Mary hospital from March, 2009 to December, 2013. The records of these patients were retrospectively reviewed. Results: 29 patients (52.7%) had normal MRI findings, and 26 patients (47.3%) had abnormal MRI findings. The inattention type of ADHD (96.5%) was the largest type in a group of normal brain MRI findings, but the combined type (53.8%) and the inattention type (46.2%) occupied the majority in a group of abnormal MRI findings. The score of symptom in inattention was 7.44/9 in a group of normal MRI findings, while 8.2/9 in a group of abnormal MRI findings. And the score of symptom in hyperactivity was 2.93/9 in a group of normal MRI findings, while it was 4.8/9 in a group of abnormal MRI findings (P<0.001). 7 patients (12.7%) revealed hippocampal sclerosis out of 26 abnormal MRI findings, and they had significantly higher scores of ADHD symptoms (8.57/9, 4.8/9) compared to normal group (7.83/9, 4.23/9). Conclusion: Abnormal MRI findings in children with epilepsy are not only closely related to ADHD but may also be associated with the severity of ADHD.

최근 우리나라 겨울철 기온의 특성 변화

문자연,편도의,박창용,최영은 한국기상학회 2014 한국기상학회 학술대회 논문집 Vol.2014 No.10

유니버설 디자인 측면에서의 실버 커뮤니티 사이트 디자인에 관한 분석

문자현(Moon Ja Hyun),전양덕(Chun Yang Deok) 한국디자인학회 2007 한국디자인학회 학술발표대회 논문집 Vol.- No.-

New Aspect of Intraseasonal Tropical-Extratropical Interaction

문자연,하경자 한국기상학회 2008 한국기상학회 학술대회 논문집 Vol.2008 No.-

Current Pharmacologic Strategies for Treatment of Intractable Epilepsy in Children

문자운,조경옥 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.S1

Epileptic encephalopathy (EE) is a devastating pediatric disease that features medically resistant seizures, which can contribute to global developmental delays. Despite technological advancements in genetics, the neurobiological mechanisms of EEs are not fully understood, leaving few therapeutic options for affected patients. In this review, we introduce the most common EEs in pediatrics (i.e., Ohtahara syndrome, Dravet syndrome, and Lennox-Gastaut syndrome) and their molecular mechanisms that cause excitation/inhibition imbalances. We then discuss some of the essential molecules that are frequently dysregulated in EEs. Specifically, we explore voltage-gated ion channels, synaptic transmission-related proteins, and ligand-gated ion channels in association with the pathophysiology of Ohtahara syndrome, Dravet syndrome, and Lennox-Gastaut syndrome. Finally, we review currently available antiepileptic drugs used to treat seizures in patients with EEs. Since these patients often fail to achieve seizure relief even with the combination therapy, further extensive research efforts to explore the involved molecular mechanisms will be required to develop new drugs for patients with intractable epilepsy.