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문자,박재영,최인,문홍섭,최준식 한국병원약사회 1994 병원약사회지 Vol.11 No.1
Drug effect depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of preparations for drug choice among preparations by dissolution test and content uniformity test of commercial diazepam tablets. Diazepam is benzodiazepines and has sedative action. The dissolution test was conducted in artificial gastric juice and artificial intestinal juice using Basket method with four diazepam preparations (A, B, C, D) which were pharmaceutically equivalent. The results were as following: 1) The dissolution rate in artificial gastric juice was higher in the order of four different brands D>A>B>C. 2) The dissolution rate in artificial intestinal juice was higher in the order of four different brands B>A>C>D. 3) Content uniformity of four different brands was better in such order as D>B>C>A. The relationship between each results was not established.
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문자 한국농촌간호학회 2007 한국농촌간호학회지 Vol.2 No.2
본 연구의 목적은 앞으로 실버타운 이용 가능성이 높 은 중년층을 대상으로 노후생활에 대한 인식정도, 실버 타운에 대한 인지도, 실버타운에서 제공되는 서비스에 따라 선호도를 분석함으로써 저비용, 고효율의 차별화된 실버타운 개발에 기초 자료를 제공함을 목적으로 하고 있다.
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Current Pharmacologic Strategies for Treatment of Intractable Epilepsy in Children
문자운,조경옥 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.S1
Epileptic encephalopathy (EE) is a devastating pediatric disease that features medically resistant seizures, which can contribute to global developmental delays. Despite technological advancements in genetics, the neurobiological mechanisms of EEs are not fully understood, leaving few therapeutic options for affected patients. In this review, we introduce the most common EEs in pediatrics (i.e., Ohtahara syndrome, Dravet syndrome, and Lennox-Gastaut syndrome) and their molecular mechanisms that cause excitation/inhibition imbalances. We then discuss some of the essential molecules that are frequently dysregulated in EEs. Specifically, we explore voltage-gated ion channels, synaptic transmission-related proteins, and ligand-gated ion channels in association with the pathophysiology of Ohtahara syndrome, Dravet syndrome, and Lennox-Gastaut syndrome. Finally, we review currently available antiepileptic drugs used to treat seizures in patients with EEs. Since these patients often fail to achieve seizure relief even with the combination therapy, further extensive research efforts to explore the involved molecular mechanisms will be required to develop new drugs for patients with intractable epilepsy.
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Time Slice 실험으로 모의한 동아시아 여름몬순의 변화
문자연(JaYeon Moon),김문현(Moon-Hyun Kim),최다희(Da-Hee Choi),부경온(Kyung-On Boo),권원태(Won-Tae Kwon) 한국기상학회 2008 대기 Vol.18 No.1
The global time slice approach is a transient experiment using high resolution atmosphere-only model with boundary condition from the low resolution globally coupled ocean-atmosphere model. The present study employs this time slice concept using ECHAM4 atmosphere-only model at a horizontal resolution of T106 with the lower boundary forcing obtained from a lower-resolution (T42) greenhouse gas + aerosol forcing experiment performed using the ECHO-G/S (ECHAM4/HOPE-G) coupled model. In order to assess the impact of horizontal resolution on simulated East Asian summer monsoon climate, the differences in climate response between the time slice experiments of the present and that of IPCC SRES AR4 participating 21 models including coarser (T30) coupled model are compared. The higher resolution model from time slice experiment in the present climate show successful performance in simulating the northward migration and the location of the maximum rainfall during the rainy season over East Asia, although its rainfall amount was somewhat weak compared to the observation. Based on the present climate simulation, the possible change of East Asian summer monsoon rainfall in the future climate by the IPCC SRES A1B scenario, tends to be increased especially over the eastern part of Japan during July and September. The increase of the precipitation over this region seems to be related with the weakening of northwestern part of North Pacific High and the formation of anticyclonic flow over the south of Yangtze River in the future climate.
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신 기후값(1991~2020년)에 나타난 우리나라 장마기간 강수의 특성
문자연,김기영,최영은,민숙주 건국대학교 기후연구소 2020 기후연구 Vol.15 No.3
In this study, we analyzed the characteristics of climate variability in summer rainfall during Changma over three sub-sector regions (Middle, Southern, Jeju) in South Korea for the new climatological period of 1991-2020 using observation data from 60 ASOS stations. There was a significant interannual variability in rainfall, wet days, and rainfall intensity but the long-term trend of rainfall was not significant over the three sectors in South Korea. Comparing the new climatology (P2: 1991-2020) with the old one (P1: 1981-2010), it was found that the precipitation during Changma in new climatology (P2) was enhanced in Middle sector but reduced in Southern and Jeju sectors. In P2, wet days increased only a few stations in the Middle sector but the rainfall intensity was strengthened over the 50% stations including Middle sector, south and west coast of the Southern sector. Wet days above 25, 50, 75, 95%ile rainfall during Changma in Southern and Jeju sectors all decreased in P2. Climatological change from P1 to P2 showed a large variability not only in temporal frame but also in the spatial distribution in South Korea.
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